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Protein Ontology report - tyrosine-protein kinase Fyn
PR:000003003 - http://purl.obolibrary.org/obo/PR_000003003
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003003   
  PRO nametyrosine-protein kinase Fyn 
  Synonyms
PRO-Short-label: EXACT:FYN
Other: EXACT:p59-Fyn | proto-oncogene c-Fyn | proto-oncogene Syn
  Definition"A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human FYN gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000002997 proto-oncogene SRC-like tyrosine-protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 5                                        
         Modification4                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2026
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000003003

tyrosine-protein kinase Fyn

FYN


"A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human FYN gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P06241

tyrosine-protein kinase Fyn (human)

hFYN


"A tyrosine-protein kinase Fyn that is encoded in the genome of human." [PRO:CNA, UniProtKB:P06241]


organism-sequence



PR:P06241-1

tyrosine-protein kinase Fyn isoform 1 (human)

hFYN/iso:1


"A tyrosine-protein kinase Fyn isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036620

tyrosine-protein kinase Fyn isoform 1 phosphorylated 1 (human)

hFYN/iso:1/Phos:1


"A tyrosine-protein kinase Fyn isoform 1 phosphorylated 1 in human." [PMID:9043947, PRO:CL]

Yes

organism-modification



PR:000061191

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)

hFYN/iso:1/InitMet-/MyrPhos:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Tyr-420 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-9032530]


organism-modification



PR:000061276

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated 1 (human)

hFYN/iso:1/InitMet-/Myr:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068." [PRO:DNx, Reactome:R-HSA-9032506]


organism-sequence



PR:P06241-2

tyrosine-protein kinase Fyn isoform 2 (human)

hFYN/iso:2


"A tyrosine-protein kinase Fyn isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P06241-3

tyrosine-protein kinase Fyn isoform h3 (human)

hFYN/iso:h3


"A tyrosine-protein kinase Fyn (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06241-3." [PRO:DNx, UniProtKB:P06241]


organism-modification



PR:000047465

tyrosine-protein kinase Fyn, initiator methionine removed form (human)

hFYN/InitMet-


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed. UniProtKB:P06241, 2-537." [PRO:DNx, Reactome:R-HSA-200917]


organism-modification



PR:000047466

tyrosine-protein kinase Fyn, initiator methionine removed phosphorylated 2 (human)

hFYN/InitMet-/Phos:2


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at position 21, and phosphotyrosine at position 420 of the amino acid sequence represented by UniProtKB:P06241. UniProtKB:P06241, 2-537, Ser-21, MOD:00046|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-5218745]


organism-modification



PR:000047467

tyrosine-protein kinase Fyn, initiator methionine removed phosphorylated 3 (human)

hFYN/InitMet-/Phos:3


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at position 420 of the amino acid sequence represented by UniProtKB:P06241. UniProtKB:P06241, 2-537, Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-391821]


organism-modification



PR:000047468

tyrosine-protein kinase Fyn, initiator methionine removed phosphorylated 4 (human)

hFYN/InitMet-/Phos:4


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at position 531 of the amino acid sequence represented by UniProtKB:P06241. UniProtKB:P06241, 2-537, Tyr-531, MOD:00048." [PRO:DNx, Reactome:R-HSA-391819]


organism-modification



PR:000060301

tyrosine-protein kinase Fyn, initiator methionine removed myristoylated and phosphorylated 1 (human)

hFYN/InitMet-/MyrPhos:1


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Tyr-420 of the amino acid sequence represented by UniProtKB:P06241-1. Example: UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-1810410]


organism-modification



PR:000060707

tyrosine-protein kinase Fyn, initiator methionine removed myristoylated and palmitoylated 1 (human)

hFYN/InitMet-/MyrPalm:1


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and palmitoylated on the residues at the positions equivalent to Cys-3 and Cys-6 of the amino acid sequence represented by UniProtKB:P06241-1. Example: UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Cys-3/Cys-6, MOD:00115." [PRO:DNx, Reactome:R-HSA-9606873]


organism-modification



PR:000061191

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)

hFYN/iso:1/InitMet-/MyrPhos:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Tyr-420 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-9032530]


organism-modification



PR:000061276

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated 1 (human)

hFYN/iso:1/InitMet-/Myr:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068." [PRO:DNx, Reactome:R-HSA-9032506]


organism-modification



PR:000068442

tyrosine-protein kinase Fyn acetylated 1 (human)

hFYN/Ac:1


"A tyrosine-protein kinase Fyn (human) that has been acetylated on the residue at the position equivalent to Lys-201 of the amino acid sequence represented by UniProtKB:P06241-1. Example: UniProtKB:P06241-1, Lys-201, MOD:00723." [IEDB_epitope:1762314, PRO:DNx]


organism-modification



PR:000077556

tyrosine-protein kinase Fyn deaminated 1 (human)

hFYN/Deam:1


"A tyrosine-protein kinase Fyn (human) that has been deaminated on the residue at the position equivalent to Gln-272 of the amino acid sequence represented by UniProtKB:P06241-1. Example: UniProtKB:P06241-1, Gln-272, MOD:00685." [IEDB_epitope:1977301, PRO:DNx]


organism-modification



PR:000081999

tyrosine-protein kinase Fyn deaminated 2 (human)

hFYN/Deam:2


"A tyrosine-protein kinase Fyn (human) that has been deaminated on the residue at the position equivalent to Gln-424 of the amino acid sequence represented by UniProtKB:P06241-1. Example: UniProtKB:P06241-1, Gln-424, MOD:00685." [IEDB_epitope:551197, IEDB_epitope:553719, PRO:DNx]


organism-modification



PR:000083406

tyrosine-protein kinase Fyn deaminated 3 (human)

hFYN/Deam:3


"A tyrosine-protein kinase Fyn (human) that has been deaminated on the residue at the position equivalent to Gln-316 of the amino acid sequence represented by UniProtKB:P06241-1. Example: UniProtKB:P06241-1, Gln-316, MOD:00685." [IEDB_epitope:837009, PRO:DNx]


organism-gene



PR:P39688

tyrosine-protein kinase Fyn (mouse)

mFYN


"A tyrosine-protein kinase Fyn that is encoded in the genome of mouse." [OMA:P39688, PRO:CNA]


organism-sequence



PR:P39688-1

tyrosine-protein kinase Fyn isoform 1 (mouse)

mFYN/iso:1


"A tyrosine-protein kinase Fyn isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:P39688-2

tyrosine-protein kinase Fyn isoform 2 (mouse)

mFYN/iso:2


"A tyrosine-protein kinase Fyn isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q62844

tyrosine-protein kinase Fyn (rat)

rFYN


"A tyrosine-protein kinase Fyn that is encoded in the genome of rat." [OMA:Q62844, PRO:DNx]


sequence



PR:000003004

tyrosine-protein kinase Fyn isoform 1

FYN/iso:1


"A tyrosine-protein kinase Fyn that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06241-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P06241-1

tyrosine-protein kinase Fyn isoform 1 (human)

hFYN/iso:1


"A tyrosine-protein kinase Fyn isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036620

tyrosine-protein kinase Fyn isoform 1 phosphorylated 1 (human)

hFYN/iso:1/Phos:1


"A tyrosine-protein kinase Fyn isoform 1 phosphorylated 1 in human." [PMID:9043947, PRO:CL]

Yes

organism-modification



PR:000061191

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)

hFYN/iso:1/InitMet-/MyrPhos:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Tyr-420 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-9032530]


organism-modification



PR:000061276

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated 1 (human)

hFYN/iso:1/InitMet-/Myr:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068." [PRO:DNx, Reactome:R-HSA-9032506]


organism-sequence



PR:P39688-1

tyrosine-protein kinase Fyn isoform 1 (mouse)

mFYN/iso:1


"A tyrosine-protein kinase Fyn isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000003005

tyrosine-protein kinase Fyn isoform 1 phosphorylated form

FYN/iso:1/PhosRes+


"A tyrosine-protein kinase Fyn isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003006

tyrosine-protein kinase Fyn isoform 1 phosphorylated 1

FYN/iso:1/Phos:1


"A tyrosine-protein kinase Fyn isoform 1 phosphorylated form in which the phosphorylation occurs at Tyr residues upon activation of the T cell antigen receptor-mediated signal transduction pathway." [PMID:1526965, PRO:CL]


organism-modification



PR:000036620

tyrosine-protein kinase Fyn isoform 1 phosphorylated 1 (human)

hFYN/iso:1/Phos:1


"A tyrosine-protein kinase Fyn isoform 1 phosphorylated 1 in human." [PMID:9043947, PRO:CL]

Yes

organism-modification



PR:000061191

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)

hFYN/iso:1/InitMet-/MyrPhos:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Tyr-420 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-9032530]


modification



PR:000026646

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed form

FYN/iso:1/InitMet-


"A tyrosine-protein kinase Fyn isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000061191

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)

hFYN/iso:1/InitMet-/MyrPhos:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Tyr-420 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-9032530]


organism-modification



PR:000061276

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated 1 (human)

hFYN/iso:1/InitMet-/Myr:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068." [PRO:DNx, Reactome:R-HSA-9032506]


sequence



PR:000038689

tyrosine-protein kinase Fyn isoform 2

FYN/iso:2


"A tyrosine-protein kinase Fyn that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06241-2 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P06241-2

tyrosine-protein kinase Fyn isoform 2 (human)

hFYN/iso:2


"A tyrosine-protein kinase Fyn isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P39688-2

tyrosine-protein kinase Fyn isoform 2 (mouse)

mFYN/iso:2


"A tyrosine-protein kinase Fyn isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


modification



PR:000018776

tyrosine-protein kinase Fyn, initiator methionine removed form

FYN/InitMet-


"A tyrosine-protein kinase Fyn that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026646

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed form

FYN/iso:1/InitMet-


"A tyrosine-protein kinase Fyn isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000061191

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)

hFYN/iso:1/InitMet-/MyrPhos:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Tyr-420 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-9032530]


organism-modification



PR:000061276

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated 1 (human)

hFYN/iso:1/InitMet-/Myr:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068." [PRO:DNx, Reactome:R-HSA-9032506]


organism-modification



PR:000047465

tyrosine-protein kinase Fyn, initiator methionine removed form (human)

hFYN/InitMet-


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed. UniProtKB:P06241, 2-537." [PRO:DNx, Reactome:R-HSA-200917]


organism-modification



PR:000047466

tyrosine-protein kinase Fyn, initiator methionine removed phosphorylated 2 (human)

hFYN/InitMet-/Phos:2


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at position 21, and phosphotyrosine at position 420 of the amino acid sequence represented by UniProtKB:P06241. UniProtKB:P06241, 2-537, Ser-21, MOD:00046|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-5218745]


organism-modification



PR:000047467

tyrosine-protein kinase Fyn, initiator methionine removed phosphorylated 3 (human)

hFYN/InitMet-/Phos:3


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at position 420 of the amino acid sequence represented by UniProtKB:P06241. UniProtKB:P06241, 2-537, Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-391821]


organism-modification



PR:000047468

tyrosine-protein kinase Fyn, initiator methionine removed phosphorylated 4 (human)

hFYN/InitMet-/Phos:4


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at position 531 of the amino acid sequence represented by UniProtKB:P06241. UniProtKB:P06241, 2-537, Tyr-531, MOD:00048." [PRO:DNx, Reactome:R-HSA-391819]


organism-modification



PR:000060301

tyrosine-protein kinase Fyn, initiator methionine removed myristoylated and phosphorylated 1 (human)

hFYN/InitMet-/MyrPhos:1


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Tyr-420 of the amino acid sequence represented by UniProtKB:P06241-1. Example: UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-1810410]


organism-modification



PR:000060707

tyrosine-protein kinase Fyn, initiator methionine removed myristoylated and palmitoylated 1 (human)

hFYN/InitMet-/MyrPalm:1


"A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and palmitoylated on the residues at the positions equivalent to Cys-3 and Cys-6 of the amino acid sequence represented by UniProtKB:P06241-1. Example: UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Cys-3/Cys-6, MOD:00115." [PRO:DNx, Reactome:R-HSA-9606873]


organism-modification



PR:000061191

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)

hFYN/iso:1/InitMet-/MyrPhos:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Tyr-420 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-9032530]


organism-modification



PR:000061276

tyrosine-protein kinase Fyn isoform 1, initiator methionine removed myristoylated 1 (human)

hFYN/iso:1/InitMet-/Myr:1


"A tyrosine-protein kinase Fyn isoform 1 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 of the amino acid sequence represented by UniProtKB:P06241-1. UniProtKB:P06241-1, 2-537, Gly-2, MOD:00068." [PRO:DNx, Reactome:R-HSA-9032506]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005515 protein bindingPR:000036620 hFYN/iso:1/Phos:1 PMID:9043947
GO:0016301 kinase activityPR:000036620 hFYN/iso:1/Phos:1 PMID:9043947