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Protein Ontology report - leucine-rich repeat serine/threonine-protein kinase 2
PR:000003033 - http://purl.obolibrary.org/obo/PR_000003033
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000003033   
  PRO nameleucine-rich repeat serine/threonine-protein kinase 2 
  Synonyms
PRO-Short-label: EXACT:LRRK2
Gene-based: RELATED:PARK8
Other: EXACT:dardarin
  Definition"A protein that is a translation product of the human LRRK2 gene or a 1:1 ortholog thereof. LRRK2 belongs to a gene family known as Roco. Roco genes encode for large proteins that have a characteristic GTPase domain, named Roc, plus a domain of unknown function called COR. Several Roco proteins also contain a protein kinase domain. Leucine-rich repeat serine/threonine-protein kinase 2 contains an N-terminal repeat that is unique to this protein." [PMID:16966681, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2059
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000003033
leucine-rich repeat serine/threonine-protein kinase 2
LRRK2
"A protein that is a translation product of the human LRRK2 gene or a 1:1 ortholog thereof. LRRK2 belongs to a gene family known as Roco. Roco genes encode for large proteins that have a characteristic GTPase domain, named Roc, plus a domain of unknown function called COR. Several Roco proteins also contain a protein kinase domain. Leucine-rich repeat serine/threonine-protein kinase 2 contains an N-terminal repeat that is unique to this protein." [PMID:16966681, PRO:CNA]

organism-gene


PR:Q5S006
leucine-rich repeat serine/threonine-protein kinase 2 (mouse)
mLRRK2
"A leucine-rich repeat serine/threonine-protein kinase 2 that is encoded in the genome of mouse." [OMA:Q5S006, PRO:DNx]

organism-gene


PR:Q5S007
leucine-rich repeat serine/threonine-protein kinase 2 (human)
hLRRK2
"A leucine-rich repeat serine/threonine-protein kinase 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q5S007]

organism-sequence


PR:000049991
leucine-rich repeat serine/threonine-protein kinase 2 sequence variant R1628P (human)
hLRRK2/var:R1628P
"A leucine-rich repeat serine/threonine-protein kinase 2 (human) that has a Pro residue at the position equivalent to Arg-1628 of the amino acid sequence represented by UniProtKB:Q5S007. UniProtKB:Q5S007, Arg-1628, CHEBI:50342." [PRO:DAN]

organism-modification


PR:000065811
leucine-rich repeat serine/threonine-protein kinase 2 acetylated 1 (human)
hLRRK2/Ac:1
"A leucine-rich repeat serine/threonine-protein kinase 2 (human) that has been acetylated on the residue at the position equivalent to Lys-1138 of the amino acid sequence represented by UniProtKB:Q5S007. UniProtKB:Q5S007, Lys-1138, MOD:00723." [IEDB_epitope:1774379, PRO:DNx]

organism-modification


PR:000080476
leucine-rich repeat serine/threonine-protein kinase 2 deaminated 1 (human)
hLRRK2/Deam:1
"A leucine-rich repeat serine/threonine-protein kinase 2 (human) that has been deaminated on the residue at the position equivalent to Asn-467 of the amino acid sequence represented by UniProtKB:Q5S007. UniProtKB:Q5S007, Asn-467, MOD:00684." [IEDB_epitope:1359199, PRO:DNx]

organism-modification


PR:000085490
leucine-rich repeat serine/threonine-protein kinase 2 cysteinylated 1 (human)
hLRRK2/Cyst:1
"A leucine-rich repeat serine/threonine-protein kinase 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-2389 of the amino acid sequence represented by UniProtKB:Q5S007. UniProtKB:Q5S007, Cys-2389, MOD:00765." [IEDB_epitope:1015709, PRO:DNx]