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Protein Ontology report - mitogen-activated protein kinase kinase kinase kinase 4
PR:000003043 - http://purl.obolibrary.org/obo/PR_000003043
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003043   
  PRO namemitogen-activated protein kinase kinase kinase kinase 4 
  Synonyms
PRO-Short-label: EXACT:MAP4K4
Gene-based: RELATED:HGK | KIAA0687 | NIK
Other: EXACT:HPK/GCK-like kinase HGK | MAPK/ERK kinase kinase kinase 4 | MEK kinase kinase 4 | MEKKK 4 | Nck-interacting kinase
  Definition"A protein that is a translation product of the human MAP4K4 gene or a 1:1 ortholog thereof." [PMID:16938849, PRO:AL] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2088
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000003043
mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4
"A protein that is a translation product of the human MAP4K4 gene or a 1:1 ortholog thereof." [PMID:16938849, PRO:AL]

organism-gene


PR:O95819
mitogen-activated protein kinase kinase kinase kinase 4 (human)
hMAP4K4
"A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of human." [PRO:AL, UniProtKB:O95819]

organism-sequence


PR:O95819-1
mitogen-activated protein kinase kinase kinase kinase 4 isoform h1 (human)
hMAP4K4/iso:h1
"A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-1." [PRO:DNx, UniProtKB:O95819]

organism-sequence


PR:O95819-2
mitogen-activated protein kinase kinase kinase kinase 4 isoform h2 (human)
hMAP4K4/iso:h2
"A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-2." [PRO:DNx, UniProtKB:O95819]

organism-sequence


PR:O95819-3
mitogen-activated protein kinase kinase kinase kinase 4 isoform h3 (human)
hMAP4K4/iso:h3
"A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-3." [PRO:DNx, UniProtKB:O95819]

organism-sequence


PR:O95819-4
mitogen-activated protein kinase kinase kinase kinase 4 isoform h4 (human)
hMAP4K4/iso:h4
"A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-4." [PRO:DNx, UniProtKB:O95819]

organism-sequence


PR:O95819-5
mitogen-activated protein kinase kinase kinase kinase 4 isoform h5 (human)
hMAP4K4/iso:h5
"A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-5." [PRO:DNx, UniProtKB:O95819]

organism-sequence


PR:O95819-6
mitogen-activated protein kinase kinase kinase kinase 4 isoform h6 (human)
hMAP4K4/iso:h6
"A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-6." [PRO:DNx, UniProtKB:O95819]

organism-modification


PR:000048312
mitogen-activated protein kinase kinase kinase kinase 4, initiator methionine removed form (human)
hMAP4K4/InitMet-
"A mitogen-activated protein kinase kinase kinase kinase 4 (human) that has had the initiator methionine removed. UniProtKB:O95819, 2-1239." [PRO:DNx, Reactome:R-HSA-3214893]

organism-modification


PR:000075673
mitogen-activated protein kinase kinase kinase kinase 4 hydroxylated 1 (human)
hMAP4K4/Hy:1
"A mitogen-activated protein kinase kinase kinase kinase 4 (human) that has been hydroxylated on the residue at the position equivalent to Trp-1050 of the amino acid sequence represented by UniProtKB:O95819-1. Example: UniProtKB:O95819-1, Trp-1050, MOD:01622." [IEDB_epitope:1315065, PRO:DNx]

organism-gene


PR:P97820
mitogen-activated protein kinase kinase kinase kinase 4 (mouse)
mMAP4K4
"A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of mouse." [OMA:P97820, PRO:DNx]

organism-sequence


PR:P97820-1
mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 (mouse)
mMAP4K4/iso:1
"A mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 that is encoded in the genome of mouse." [PRO:AL]
Yes
organism-gene


PR:Q0WPH8
serine/threonine-protein kinase Nek5 (Arabidopsis thaliana)
At-MAP4K4
"A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of Arabidopsis thaliana." [PRO:AL]

organism-gene


PR:Q23356
serine/threonine-protein kinase mig-15 (worm)
MAP4K4 (worm)
"A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of worm." [OMA:Q23356, PRO:DAN]

organism-sequence


PR:Q23356-1
serine/threonine-protein kinase mig-15 isoform c (worm)
MAP4K4/iso:c (worm)
"A serine/threonine-protein kinase mig-15 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q23356-1." [PRO:DNx, UniProtKB:Q23356]

organism-sequence


PR:Q23356-2
serine/threonine-protein kinase mig-15 isoform a (worm)
MAP4K4/iso:a (worm)
"A serine/threonine-protein kinase mig-15 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q23356-2." [PRO:DNx, UniProtKB:Q23356]

organism-sequence


PR:Q23356-3
serine/threonine-protein kinase mig-15 isoform b (worm)
MAP4K4/iso:b (worm)
"A serine/threonine-protein kinase mig-15 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q23356-3." [PRO:DNx, UniProtKB:Q23356]

organism-sequence


PR:Q23356-4
serine/threonine-protein kinase mig-15 isoform d (worm)
MAP4K4/iso:d (worm)
"A serine/threonine-protein kinase mig-15 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q23356-4." [PRO:DNx, UniProtKB:Q23356]

sequence


PR:000003044
mitogen-activated protein kinase kinase kinase kinase 4 isoform 1
MAP4K4/iso:1
"A mitogen-activated protein kinase kinase kinase kinase 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97820-1 or a 1:1 ortholog thereof." [PMID:9135144, PRO:AL]

organism-sequence


PR:P97820-1
mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 (mouse)
mMAP4K4/iso:1
"A mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 that is encoded in the genome of mouse." [PRO:AL]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P97820-1 mMAP4K4/iso:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:16938849
GO:0010591 regulation of lamellipodium assembly PMID:16938849
enablesGO:0004674 protein serine/threonine kinase activity PMID:16938849
GO:0005515 protein binding PMID:16938849