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Protein Ontology report - conventional protein kinase C
PR:000003057 - http://purl.obolibrary.org/obo/PR_000003057
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003057   
  PRO nameconventional protein kinase C 
  Synonyms
Other: EXACT:cPKC | protein kinase C, alpha/beta/gamma types
RELATED:Calcium-dependent PKC
  Definition"A protein that is a member of the conventional phorbol ester (and diacylglycerol) receptor/protein kinase class. The canonical protein sequence has a core domain architecture consisting of two copies of the Phorbol esters/diacylglycerol binding domain (C1 domain) (Pfam:PF00130), followed by a C2 domain (Pfam:PF00168), a Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433)." [PMID:1877391
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 13                                        
         Sequence4                                                  Organism-Sequence 17                                        
         Modification3                                                  Organism-Modification 20                                        
  Term Hierarchy
  Visualization
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Related Cross References

  Db identifiers
PIRSF:PIRSF0000550
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000003057

conventional protein kinase C

TMPRSS9/iso:3/Clv:1


"A protein that is a member of the conventional phorbol ester (and diacylglycerol) receptor/protein kinase class. The canonical protein sequence has a core domain architecture consisting of two copies of the Phorbol esters/diacylglycerol binding domain (C1 domain) (Pfam:PF00130), followed by a C2 domain (Pfam:PF00168), a Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433)." [PMID:1877391]


gene



PR:000003058

protein kinase C alpha type

PRKCA


"A conventional protein kinase C that is a translation product of the human PRKCA gene or a 1:1 ortholog thereof." [PRO:CL]


organism-gene



PR:P04409

protein kinase C alpha type (cow)

cow-PRKCA


"A protein kinase C alpha type that is encoded in the genome of cow." [OMA:P04409, PRO:DNx]


organism-gene



PR:P05130

protein kinase C, brain isozyme (fruit fly)

fly-PRKCA


"A protein kinase C alpha type that is encoded in the genome of fruit fly." [PRO:CL]


organism-sequence



PR:P05130-1

protein kinase C, brain isozyme isoform Long (fruit fly)

fly-PRKCA/iso:Long


"A protein kinase C, brain isozyme (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05130-1." [PRO:DNx, UniProtKB:P05130]


organism-sequence



PR:P05130-2

protein kinase C, brain isozyme isoform Short (fruit fly)

fly-PRKCA/iso:Short


"A protein kinase C, brain isozyme (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05130-2." [PRO:DNx, UniProtKB:P05130]


organism-gene



PR:P05696

protein kinase C alpha type (rat)

rPRKCA


"A protein kinase C alpha type that is encoded in the genome of rat." [OMA:P05696, PRO:DNx]


organism-sequence



PR:P05696-1

protein kinase C alpha type isoform 1 (rat)

rPRKCA/iso:1


"A protein kinase C alpha type isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:P17252

protein kinase C alpha type (human)

hPRKCA


"A protein kinase C alpha type that is encoded in the genome of human." [PRO:CL, UniProtKB:P17252]


organism-sequence



PR:P17252-1

protein kinase C alpha type isoform 1 (human)

hPRKCA/iso:1


"A protein kinase C alpha type isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000048910

protein kinase C alpha type, initiator methionine removed form (human)

hPRKCA/InitMet-


"A protein kinase C alpha type (human) that has had the initiator methionine removed. UniProtKB:P17252, 2-672." [PRO:DNx, Reactome:R-HSA-156469, Reactome:R-HSA-2648987, Reactome:R-HSA-450530, Reactome:R-HSA-58196]


organism-modification



PR:000048911

protein kinase C alpha type, initiator methionine removed phosphorylated 1 (human)

hPRKCA/InitMet-/Phos:1


"A protein kinase C alpha type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 497 of the amino acid sequence represented by UniProtKB:P17252. UniProtKB:P17252, 2-672, Thr-497, MOD:00047." [PRO:DNx, Reactome:R-HSA-5218731]


organism-modification



PR:000048912

protein kinase C alpha type, initiator methionine removed phosphorylated 2 (human)

hPRKCA/InitMet-/Phos:2


"A protein kinase C alpha type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 497 and 638, and phosphoserine at position 657 of the amino acid sequence represented by UniProtKB:P17252. UniProtKB:P17252, 2-672, Thr-497/Thr-638, MOD:00047|Ser-657, MOD:00046." [PRO:DNx, Reactome:R-HSA-4332337, Reactome:R-HSA-4332340, Reactome:R-HSA-5223292]


organism-gene



PR:P20444

protein kinase C alpha type (mouse)

mPRKCA


"A protein kinase C alpha type that is encoded in the genome of mouse." [OMA:P20444, PRO:DNx]


organism-modification



PR:000046148

protein kinase C alpha type phosphorylated 1 (mouse)

mPRKCA/Phos:1


"A protein kinase C alpha type (mouse) that has been phosphorylated at Thr-638. UniProtKB:P20444, Thr-638, MOD:00047." [iPTMnet:P20444, PMID:20513439]


organism-gene



PR:P90980

protein kinase C-like 2 (worm)

PRKCA (worm)


"A protein kinase C alpha type that is encoded in the genome of worm." [PRO:CL]


organism-sequence



PR:P90980-1

protein kinase C-like 2 isoform b (worm)

PRKCA/iso:b (worm)


"A protein kinase C-like 2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P90980-1." [PRO:DNx, UniProtKB:P90980]


organism-sequence



PR:P90980-2

protein kinase C-like 2 isoform a (worm)

PRKCA/iso:a (worm)


"A protein kinase C-like 2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P90980-2." [PRO:DNx, UniProtKB:P90980]


organism-sequence



PR:P90980-3

protein kinase C-like 2 isoform c (worm)

PRKCA/iso:c (worm)


"A protein kinase C-like 2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P90980-3." [PRO:DNx, UniProtKB:P90980]


sequence



PR:000038974

protein kinase C alpha type isoform 1

PRKCA/iso:1


"A protein kinase C alpha type that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17252-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P05696-1

protein kinase C alpha type isoform 1 (rat)

rPRKCA/iso:1


"A protein kinase C alpha type isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:P17252-1

protein kinase C alpha type isoform 1 (human)

hPRKCA/iso:1


"A protein kinase C alpha type isoform 1 that is encoded in the genome of human." [PRO:DNx]


modification



PR:000018782

protein kinase C alpha type, initiator methionine removed form

PRKCA/InitMet-


"A protein kinase C alpha type that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000048910

protein kinase C alpha type, initiator methionine removed form (human)

hPRKCA/InitMet-


"A protein kinase C alpha type (human) that has had the initiator methionine removed. UniProtKB:P17252, 2-672." [PRO:DNx, Reactome:R-HSA-156469, Reactome:R-HSA-2648987, Reactome:R-HSA-450530, Reactome:R-HSA-58196]


organism-modification



PR:000048911

protein kinase C alpha type, initiator methionine removed phosphorylated 1 (human)

hPRKCA/InitMet-/Phos:1


"A protein kinase C alpha type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 497 of the amino acid sequence represented by UniProtKB:P17252. UniProtKB:P17252, 2-672, Thr-497, MOD:00047." [PRO:DNx, Reactome:R-HSA-5218731]


organism-modification



PR:000048912

protein kinase C alpha type, initiator methionine removed phosphorylated 2 (human)

hPRKCA/InitMet-/Phos:2


"A protein kinase C alpha type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 497 and 638, and phosphoserine at position 657 of the amino acid sequence represented by UniProtKB:P17252. UniProtKB:P17252, 2-672, Thr-497/Thr-638, MOD:00047|Ser-657, MOD:00046." [PRO:DNx, Reactome:R-HSA-4332337, Reactome:R-HSA-4332340, Reactome:R-HSA-5223292]


gene



PR:000003059

protein kinase C beta type

PRKCB


"A conventional protein kinase C that is a translation product of the human PRKCB gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P05771

protein kinase C beta type (human)

hPRKCB


"A protein kinase C beta type that is encoded in the genome of human." [PRO:CNA, UniProtKB:P05771]


organism-sequence



PR:P05771-1

protein kinase C beta type isoform Beta-I (human)

hPRKCB/iso:Beta-I


"A protein kinase C beta type isoform 1 that is encoded in the genome of human." [PRO:DNx]

Yes

organism-sequence



PR:P05771-2

protein kinase C beta type isoform Beta-II (human)

hPRKCB/iso:Beta-II


"A protein kinase C beta type isoform 2 that is encoded in the genome of human." [PRO:DNx]

Yes

organism-modification



PR:000049853

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049854

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and lacks a phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000049855

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049856

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500,a phosphothreonine at position 641 and a phosphoserine at position 660. UniProtKB:P05771-2, 2-673, Thr-500/Thr-641/Ser-660, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000048913

protein kinase C beta type, initiator methionine removed form (human)

hPRKCB/InitMet-


"A protein kinase C beta type (human) that has had the initiator methionine removed. UniProtKB:P05771, 2-671." [PRO:DNx, Reactome:R-HSA-156467, Reactome:R-HSA-58198]


organism-modification



PR:000048914

protein kinase C beta type, initiator methionine removed phosphorylated 1 (human)

hPRKCB/InitMet-/Phos:1


"A protein kinase C beta type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the amino acid sequence represented by UniProtKB:P05771. UniProtKB:P05771, 2-671, Thr-500, MOD:00047." [PRO:DNx, Reactome:R-HSA-5218728]


organism-modification



PR:000048915

protein kinase C beta type, initiator methionine removed phosphorylated 2 (human)

hPRKCB/InitMet-/Phos:2


"A protein kinase C beta type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 500 and 642, and phosphoserine at position 661 of the amino acid sequence represented by UniProtKB:P05771. UniProtKB:P05771, 2-671, Thr-500/Thr-642, MOD:00047|Ser-661, MOD:00046." [PRO:DNx, Reactome:R-HSA-5218706, Reactome:R-HSA-5223294]


organism-modification



PR:000049853

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049854

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and lacks a phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000049855

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049856

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500,a phosphothreonine at position 641 and a phosphoserine at position 660. UniProtKB:P05771-2, 2-673, Thr-500/Thr-641/Ser-660, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000049887

protein kinase C beta type phosphorylated 1 (human)

hPRKCB/Phos:1


"A protein kinase C beta type phosphorylated 1 in human. UniProtKB:P05771, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]


organism-gene



PR:P68403

protein kinase C beta type (rat)

rPRKCB


"A protein kinase C beta type that is encoded in the genome of rat." [OMA:P68403, PRO:DNx]


organism-sequence



PR:P68403-1

protein kinase C beta type isoform Beta-I (rat)

rPRKCB/iso:Beta-I


"A protein kinase C beta type (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P68403-1." [PRO:DNx, UniProtKB:P68403]


organism-sequence



PR:P68403-2

protein kinase C beta type isoform Beta-II (rat)

rPRKCB/iso:Beta-II


"A protein kinase C beta type (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P68403-2." [PRO:DNx, UniProtKB:P68403]


organism-gene



PR:P68404

protein kinase C beta type (mouse)

mPRKCB


"A protein kinase C beta type that is encoded in the genome of mouse." [OMA:MOUSE21322, PRO:DNx]


organism-sequence



PR:P68404-1

protein kinase C beta type isoform Beta-I (mouse)

mPRKCB/iso:Beta-I


"A protein kinase C beta type isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000049880

protein kinase C beta type isoform Beta-I phosphorylated 1 (mouse)

mPRKCB/iso:Beta-I/Phos:1


"A protein kinase C beta type isoform Beta-I (mouse) that has been phosphorylated at position Thr-642. UniProtKB:P68404-1, Thr-642, MOD:00047." [PMID:21183079, PRO:DAN, PRO:HJD]


organism-sequence



PR:P68404-2

protein kinase C beta type isoform Beta-II (mouse)

mPRKCB/iso:Beta-II


"A protein kinase C beta type isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000049876

protein kinase C beta type isoform Beta-II phosphorylated 1 (mouse)

mPRKCB/iso:Beta-II/Phos:1


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at position Thr-641. UniProtKB:P68404-2, Thr-641, MOD:00047." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049877

protein kinase C beta type isoform Beta-II phosphorylated 2 (mouse)

mPRKCB/iso:Beta-II/Phos:2


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at Ser-654 and Ser-660. UniProtKB:P68404-2, Ser-654/Ser-660, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049878

protein kinase C beta type isoform Beta-II phosphorylated 3 (mouse)

mPRKCB/iso:Beta-II/Phos:3


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at Ser-660 and Ser-664. UniProtKB:P68404-2, Ser-660/Ser-664, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049879

protein kinase C beta type isoform Beta-II phosphorylated 4 (mouse)

mPRKCB/iso:Beta-II/Phos:4


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at Ser-660 and Ser-673. UniProtKB:P68404-2, Ser-660/Ser-673, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049881

protein kinase C beta type phosphorylated 2 (mouse)

mPRKCB/Phos:2


"A protein kinase C beta type (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-206 of the amino acid sequence represented by UniProtKB:P68404-1. Example: UniProtKB:P68404-1, Ser-206, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049882

protein kinase C beta type phosphorylated 1 (mouse)

mPRKCB/Phos:1


"A protein kinase C beta type phosphorylated 1 in mouse. Example: UniProtKB:P68404-1, Thr-500, MOD:00047." [PMID:21183079, PRO:DAN, PRO:HJD]


organism-modification



PR:000049883

protein kinase C beta type phosphorylated 3 (mouse)

mPRKCB/Phos:3


"A protein kinase C beta type (mouse) that has been phosphorylated on the residue at the position equivalent to Thr-504 of the amino acid sequence represented by UniProtKB:P68404-1. Example: UniProtKB:P68404-1, Thr-504, MOD:00047." [PMID:21183079, PRO:HJD]


organism-gene



PR:Q7SY24

protein kinase C beta type (zebrafish)

z-PRKCB


"A protein kinase C beta type that is encoded in the genome of zebrafish." [PRO:CNA]


sequence



PR:000038682

protein kinase C beta type isoform 1

PRKCB/iso:1


"A protein kinase C beta type that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05771-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P05771-1

protein kinase C beta type isoform Beta-I (human)

hPRKCB/iso:Beta-I


"A protein kinase C beta type isoform 1 that is encoded in the genome of human." [PRO:DNx]

Yes

organism-sequence



PR:P68404-1

protein kinase C beta type isoform Beta-I (mouse)

mPRKCB/iso:Beta-I


"A protein kinase C beta type isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000049880

protein kinase C beta type isoform Beta-I phosphorylated 1 (mouse)

mPRKCB/iso:Beta-I/Phos:1


"A protein kinase C beta type isoform Beta-I (mouse) that has been phosphorylated at position Thr-642. UniProtKB:P68404-1, Thr-642, MOD:00047." [PMID:21183079, PRO:DAN, PRO:HJD]


sequence



PR:000038683

protein kinase C beta type isoform 2

PRKCB/iso:2


"A protein kinase C beta type that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05771-2 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P05771-2

protein kinase C beta type isoform Beta-II (human)

hPRKCB/iso:Beta-II


"A protein kinase C beta type isoform 2 that is encoded in the genome of human." [PRO:DNx]

Yes

organism-modification



PR:000049853

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049854

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and lacks a phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000049855

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049856

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500,a phosphothreonine at position 641 and a phosphoserine at position 660. UniProtKB:P05771-2, 2-673, Thr-500/Thr-641/Ser-660, PR:000026291." [PMID:8749392, PRO:KER]


organism-sequence



PR:P68404-2

protein kinase C beta type isoform Beta-II (mouse)

mPRKCB/iso:Beta-II


"A protein kinase C beta type isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000049876

protein kinase C beta type isoform Beta-II phosphorylated 1 (mouse)

mPRKCB/iso:Beta-II/Phos:1


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at position Thr-641. UniProtKB:P68404-2, Thr-641, MOD:00047." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049877

protein kinase C beta type isoform Beta-II phosphorylated 2 (mouse)

mPRKCB/iso:Beta-II/Phos:2


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at Ser-654 and Ser-660. UniProtKB:P68404-2, Ser-654/Ser-660, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049878

protein kinase C beta type isoform Beta-II phosphorylated 3 (mouse)

mPRKCB/iso:Beta-II/Phos:3


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at Ser-660 and Ser-664. UniProtKB:P68404-2, Ser-660/Ser-664, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049879

protein kinase C beta type isoform Beta-II phosphorylated 4 (mouse)

mPRKCB/iso:Beta-II/Phos:4


"A protein kinase C beta type isoform Beta-II (mouse) that has been phosphorylated at Ser-660 and Ser-673. UniProtKB:P68404-2, Ser-660/Ser-673, MOD:00046." [PMID:21183079, PRO:HJD]


modification



PR:000018783

protein kinase C beta type, initiator methionine removed form

PRKCB/InitMet-


"A protein kinase C beta type that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000048913

protein kinase C beta type, initiator methionine removed form (human)

hPRKCB/InitMet-


"A protein kinase C beta type (human) that has had the initiator methionine removed. UniProtKB:P05771, 2-671." [PRO:DNx, Reactome:R-HSA-156467, Reactome:R-HSA-58198]


organism-modification



PR:000048914

protein kinase C beta type, initiator methionine removed phosphorylated 1 (human)

hPRKCB/InitMet-/Phos:1


"A protein kinase C beta type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the amino acid sequence represented by UniProtKB:P05771. UniProtKB:P05771, 2-671, Thr-500, MOD:00047." [PRO:DNx, Reactome:R-HSA-5218728]


organism-modification



PR:000048915

protein kinase C beta type, initiator methionine removed phosphorylated 2 (human)

hPRKCB/InitMet-/Phos:2


"A protein kinase C beta type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 500 and 642, and phosphoserine at position 661 of the amino acid sequence represented by UniProtKB:P05771. UniProtKB:P05771, 2-671, Thr-500/Thr-642, MOD:00047|Ser-661, MOD:00046." [PRO:DNx, Reactome:R-HSA-5218706, Reactome:R-HSA-5223294]


organism-modification



PR:000049853

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049854

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and lacks a phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000049855

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049856

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500,a phosphothreonine at position 641 and a phosphoserine at position 660. UniProtKB:P05771-2, 2-673, Thr-500/Thr-641/Ser-660, PR:000026291." [PMID:8749392, PRO:KER]


modification



PR:000049888

protein kinase C beta type phosphorylated 1

PRKCB/Phos:1


"A protein kinase C beta type that has been phosphorylated on the residue at the position equivalent to Thr-500 of the amino acid sequence represented by UniProtKB:P05771-2. Example: UniProtKB:P05771-2, Thr-500, MOD:00047." [PMID:21183079, PMID:8749392, PRO:HJD, PRO:KER]


organism-modification



PR:000049882

protein kinase C beta type phosphorylated 1 (mouse)

mPRKCB/Phos:1


"A protein kinase C beta type phosphorylated 1 in mouse. Example: UniProtKB:P68404-1, Thr-500, MOD:00047." [PMID:21183079, PRO:DAN, PRO:HJD]


organism-modification



PR:000049887

protein kinase C beta type phosphorylated 1 (human)

hPRKCB/Phos:1


"A protein kinase C beta type phosphorylated 1 in human. UniProtKB:P05771, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]


gene



PR:000003060

protein kinase C gamma type

PRKCG


"A conventional protein kinase C that is a translation product of the human PRKCG gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P05129

protein kinase C gamma type (human)

hPRKCG


"A protein kinase C gamma type that is encoded in the genome of human." [PRO:CNA, UniProtKB:P05129]


organism-sequence



PR:P05129-1

protein kinase C gamma type isoform 1 (human)

hPRKCG/iso:1


"A protein kinase C gamma type isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P05129-2

protein kinase C gamma type isoform h2 (human)

hPRKCG/iso:h2


"A protein kinase C gamma type (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05129-2." [PRO:DNx, UniProtKB:P05129]


organism-gene



PR:P63318

protein kinase C gamma type (mouse)

mPRKCG


"A protein kinase C gamma type that is encoded in the genome of mouse." [OMA:P63318, PRO:DNx]


organism-sequence



PR:P63318-1

protein kinase C gamma type isoform 1 (mouse)

mPRKCG/iso:1


"A protein kinase C gamma type isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:P63319

protein kinase C gamma type (rat)

rPRKCG


"A protein kinase C gamma type that is encoded in the genome of rat." [OMA:P63319, PRO:DNx]


organism-sequence



PR:P63319-1

protein kinase C gamma type isoform 1 (rat)

rPRKCG/iso:1


"A protein kinase C gamma type isoform 1 that is encoded in the genome of rat." [PRO:DNx]


sequence



PR:000038667

protein kinase C gamma type isoform 1

PRKCG/iso:1


"A protein kinase C gamma type that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05129-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P05129-1

protein kinase C gamma type isoform 1 (human)

hPRKCG/iso:1


"A protein kinase C gamma type isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P63318-1

protein kinase C gamma type isoform 1 (mouse)

mPRKCG/iso:1


"A protein kinase C gamma type isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P63319-1

protein kinase C gamma type isoform 1 (rat)

rPRKCG/iso:1


"A protein kinase C gamma type isoform 1 that is encoded in the genome of rat." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000049853 hPRKCB/iso:Beta-II/InitMet-/Phos:1
UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000049854 hPRKCB/iso:Beta-II/InitMet-/UnPhos:1 PMID:8749392
located_inGO:0005737 cytoplasm PMID:9756933
GO:0005886 plasma membrane PMID:9756933
PR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2
UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046
acts_upstream_of_or_withinincreased GO:0006468 protein phosphorylation relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:8749392
enablesincreased GO:0001786 phosphatidylserine binding relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
increased GO:0005509 calcium ion binding relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
located_inincreased GO:0005737 cytoplasm relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9756933
PR:P05771-1 hPRKCB/iso:Beta-I acts_upstream_of_or_withinNOT GO:0001666 response to hypoxia MGI_ref:3847400; PMID:18323529
located_inGO:0016020 membrane MGI_ref:3847400; PMID:18323529
PR:P05771-2 hPRKCB/iso:Beta-II acts_upstream_of_or_withinGO:0001666 response to hypoxia MGI_ref:3847400; PMID:18323529
located_inGO:0016020 membrane MGI_ref:3847400; PMID:18323529