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Protein Ontology report - SYK/ZAP-70 family tyrosine-protein kinase
PR:000003063 - http://purl.obolibrary.org/obo/PR_000003063
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003063   
  PRO nameSYK/ZAP-70 family tyrosine-protein kinase 
  Synonyms
Other: EXACT:tyrosine-protein kinase, SYK/ZAP-70 type
  Definition"A protein that is a translation product of the human SYK or ZAP70 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PMID:8520027, PMID:9140060, PRO:CNA, PRO:DAN] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 7                                        
         Sequence3                                                  Organism-Sequence 11                                        
         Modification4                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000604
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000003063

SYK/ZAP-70 family tyrosine-protein kinase

CD247/iso:CD3 zeta/Phos:1


"A protein that is a translation product of the human SYK or ZAP70 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PMID:8520027, PMID:9140060, PRO:CNA, PRO:DAN]


gene



PR:000003064

tyrosine-protein kinase ZAP-70

ZAP70


"A SYK/ZAP-70 family tyrosine-protein kinase that is a translation product of the human ZAP70 gene or a 1:1 ortholog thereof." [PRO:CL]


organism-gene



PR:A0A0R4J8U1

tyrosine-protein kinase (rat)

rZAP70


"A tyrosine-protein kinase ZAP-70 that is encoded in the genome of rat." [PRO:CL]


organism-gene



PR:P43403

tyrosine-protein kinase ZAP-70 (human)

hZAP70


"A tyrosine-protein kinase ZAP-70 that is encoded in the genome of human." [PRO:CL, UniProtKB:P43403]


organism-sequence



PR:P43403-1

tyrosine-protein kinase ZAP-70 isoform 1 (human)

hZAP70/iso:1


"A tyrosine-protein kinase ZAP-70 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036629

tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 (human)

hZAP70/iso:1/Phos:1


"A tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 in human." [PMID:9269777, PRO:CL]

Yes

organism-sequence



PR:P43403-2

tyrosine-protein kinase ZAP-70 isoform 2 (human)

hZAP70/iso:2


"A tyrosine-protein kinase ZAP-70 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P43403-3

tyrosine-protein kinase ZAP-70 isoform h3 (human)

hZAP70/iso:h3


"A tyrosine-protein kinase ZAP-70 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43403-3." [PRO:DNx, UniProtKB:P43403]


organism-modification



PR:000045788

tyrosine-protein kinase ZAP-70 phosphorylated 1 (human)

hZAP70/Phos:1


"A tyrosine-protein kinase ZAP-70 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-319 of the amino acid sequence represented by UniProtKB:P43403-1. Example: UniProtKB:P43403-1, Tyr-319, MOD:00048." [iPTMnet:P43403, PMID:10202147, PMID:10318843, PMID:15292262]


organism-modification



PR:000049722

tyrosine-protein kinase ZAP-70 phosphorylated 2 (human)

hZAP70/Phos:2


"A tyrosine-protein kinase ZAP-70 (human) that has been phosphorylated on residues at positions equivalent to Thr-315 and Thr-493 of the amino acid sequence represented by UniProtKB:P43403-1. Example: UniProtKB:P43403-1, Tyr-315/Tyr-493, MOD:00048." [PRO:DNx, Reactome:R-HSA-202252]


organism-modification



PR:000049723

tyrosine-protein kinase ZAP-70 phosphorylated 3 (human)

hZAP70/Phos:3


"A tyrosine-protein kinase ZAP-70 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-493 of the amino acid sequence represented by UniProtKB:P43403-1. Example: UniProtKB:P43403-1, Tyr-493, MOD:00048." [PRO:DNx, Reactome:R-HSA-202368]


organism-gene



PR:P43404

tyrosine-protein kinase ZAP-70 (mouse)

mZAP70


"A tyrosine-protein kinase ZAP-70 that is encoded in the genome of mouse." [OMA:P43404, PRO:DNx]


organism-sequence



PR:P43404-1

tyrosine-protein kinase ZAP-70 isoform 1 (mouse)

mZAP70/iso:1


"A tyrosine-protein kinase ZAP-70 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:P43404-2

tyrosine-protein kinase ZAP-70 isoform 2 (mouse)

mZAP70/iso:2


"A tyrosine-protein kinase ZAP-70 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P43404-3

tyrosine-protein kinase ZAP-70 isoform m3 (mouse)

mZAP70/iso:m3


"A tyrosine-protein kinase ZAP-70 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43404-3." [PRO:DNx, UniProtKB:P43404]


sequence



PR:000003066

tyrosine-protein kinase ZAP-70 isoform 1

ZAP70/iso:1


"A tyrosine-protein kinase ZAP-70 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43403-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P43403-1

tyrosine-protein kinase ZAP-70 isoform 1 (human)

hZAP70/iso:1


"A tyrosine-protein kinase ZAP-70 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036629

tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 (human)

hZAP70/iso:1/Phos:1


"A tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 in human." [PMID:9269777, PRO:CL]

Yes

organism-sequence



PR:P43404-1

tyrosine-protein kinase ZAP-70 isoform 1 (mouse)

mZAP70/iso:1


"A tyrosine-protein kinase ZAP-70 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000003067

tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated form

ZAP70/iso:1/PhosRes+


"A tyrosine-protein kinase ZAP-70 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003068

tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1

ZAP70/iso:1/Phos:1


"A tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated form in which the phosphorylation occurs on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck, following TCR engagement. Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. It has been shown that Tyr-319 in the human sequence is required for the positive regulation of ZAP-70 function." [PMID:10037717, PRO:CL]


organism-modification



PR:000036629

tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 (human)

hZAP70/iso:1/Phos:1


"A tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 in human." [PMID:9269777, PRO:CL]

Yes

sequence



PR:000039469

tyrosine-protein kinase ZAP-70 isoform 2

ZAP70/iso:2


"A tyrosine-protein kinase ZAP-70 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43403-2 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P43403-2

tyrosine-protein kinase ZAP-70 isoform 2 (human)

hZAP70/iso:2


"A tyrosine-protein kinase ZAP-70 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P43404-2

tyrosine-protein kinase ZAP-70 isoform 2 (mouse)

mZAP70/iso:2


"A tyrosine-protein kinase ZAP-70 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000003065

tyrosine-protein kinase SYK

SYK


"A SYK/ZAP-70 family tyrosine-protein kinase that is a translation product of the human SYK gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:F1N9Y5

tyrosine-protein kinase SYK (chicken)

chick-SYK


"A tyrosine-protein kinase SYK that is encoded in the genome of chicken." [OMA:F1N9Y5, PRO:DNx]


organism-gene



PR:P43405

tyrosine-protein kinase SYK (human)

hSYK


"A tyrosine-protein kinase SYK that is encoded in the genome of human." [PRO:CNA, UniProtKB:P43405]


organism-sequence



PR:P43405-1

tyrosine-protein kinase SYK isoform Long (human)

hSYK/iso:Long


"A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P43405-2

tyrosine-protein kinase SYK isoform Short (human)

hSYK/iso:Short


"A tyrosine-protein kinase SYK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43405-2." [PRO:DNx, UniProtKB:P43405]


organism-modification



PR:000049392

tyrosine-protein kinase SYK phosphotyrosine form (human)

hSYK/PhosTyr+


"A tyrosine-protein kinase SYK (human) that includes at least one phosphorylated tyrosine. UniProtKB:P43405, MOD:00048." [PRO:DNx, Reactome:R-HSA-429432]


organism-modification



PR:000026221

tyrosine-protein kinase SYK phosphorylated 2 (human)

hSYK/Phos:2


"A tyrosine-protein kinase SYK phosphorylated 2 in human. UniProtKB:P43405, Tyr-348, MOD:00048." [PRO:CNx, Reactome:R-HSA-437953]


organism-modification



PR:000049391

tyrosine-protein kinase SYK phosphorylated 3 (human)

hSYK/Phos:3


"A tyrosine-protein kinase SYK (human) that has been post-translationally modified to include phosphotyrosine at positions 131, 323, 348, 352, 525 and 526 of the amino acid sequence represented by UniProtKB:P43405. UniProtKB:P43405, Tyr-131/Tyr-323/Tyr-348/Tyr-352/Tyr-525/Tyr-526, MOD:00048." [PRO:DNx, Reactome:R-HSA-1861712]


organism-modification



PR:000070011

tyrosine-protein kinase SYK cysteinylated 1 (human)

hSYK/Cyst:1


"A tyrosine-protein kinase SYK (human) that has been cysteinylated on the residue at the position equivalent to Cys-608 of the amino acid sequence represented by UniProtKB:P43405-1. Example: UniProtKB:P43405-1, Cys-608, MOD:00765." [IEDB_epitope:1564625, PRO:DNx]


organism-modification



PR:000071958

tyrosine-protein kinase SYK deaminated 1 (human)

hSYK/Deam:1


"A tyrosine-protein kinase SYK (human) that has been deaminated on the residue at the position equivalent to Asn-499 of the amino acid sequence represented by UniProtKB:P43405-1. Example: UniProtKB:P43405-1, Asn-499, MOD:00684." [IEDB_epitope:1583099, PRO:DNx]


organism-gene



PR:P48025

tyrosine-protein kinase SYK (mouse)

mSYK


"A tyrosine-protein kinase SYK that is encoded in the genome of mouse." [OMA:P48025, PRO:DNx]


organism-sequence



PR:P48025-1

tyrosine-protein kinase SYK isoform 1 (mouse)

mSYK/iso:1


"A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000025834

tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)

mSYK/iso:1/Phos:1


"A tyrosine-protein kinase SYK isoform 1 phosphorylated 1 in mouse. UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:JAN]

Yes

organism-modification



PR:000049791

tyrosine-protein kinase SYK isoform 1 phosphorylated 2 (mouse)

mSYK/iso:1/Phos:2


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342. UniProtKB:P48025-1, Tyr-342, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049792

tyrosine-protein kinase SYK isoform 1 unphosphorylated 2 (mouse)

mSYK/iso:1/UnPhos:2


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 342. UniProtKB:P48025-1, Tyr-342, PR:000026291." [PMID:27609517, PRO:LN]


organism-modification



PR:000049793

tyrosine-protein kinase SYK isoform 1 phosphorylated 3 (mouse)

mSYK/iso:1/Phos:3


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-346. UniProtKB:P48025-1, Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049794

tyrosine-protein kinase SYK isoform 1 unphosphorylated 3 (mouse)

mSYK/iso:1/UnPhos:3


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 346. UniProtKB:P48025-1, Tyr-346, PR:000026291." [PMID:27609517, PRO:LN]


organism-modification



PR:000049795

tyrosine-protein kinase SYK isoform 1 phosphorylated 4 (mouse)

mSYK/iso:1/Phos:4


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342 and Tyr-346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049796

tyrosine-protein kinase SYK isoform 1 phosphorylated 5 (mouse)

mSYK/iso:1/Phos:5


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342, Tyr-346, Tyr-519 and Tyr-520. UniProtKB:P48025-1, Tyr-342/Tyr-346/Tyr-519/Tyr-520, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049800

tyrosine-protein kinase SYK isoform 1 phosphorylated 6 (mouse)

mSYK/iso:1/Phos:6


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at positions 519 and 520, but it is still phosphorylated at Tyr 342 and 346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048|Tyr-519/Tyr-520, PR:000026291." [PMID:27609517, PRO:LN]


organism-gene



PR:Q64725

tyrosine-protein kinase SYK (rat)

rSYK


"A tyrosine-protein kinase SYK that is encoded in the genome of rat." [OMA:Q64725, PRO:DNx]


organism-sequence



PR:Q64725-1

tyrosine-protein kinase SYK isoform SykB (rat)

rSYK/iso:SykB


"A tyrosine-protein kinase SYK (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64725-1." [PRO:DNx, UniProtKB:Q64725]


organism-sequence



PR:Q64725-2

tyrosine-protein kinase SYK isoform SykA (rat)

rSYK/iso:SykA


"A tyrosine-protein kinase SYK (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64725-2." [PRO:DNx, UniProtKB:Q64725]


sequence



PR:000025832

tyrosine-protein kinase SYK isoform 1

SYK/iso:1


"A tyrosine-protein kinase SYK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48025-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P43405-1

tyrosine-protein kinase SYK isoform Long (human)

hSYK/iso:Long


"A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P48025-1

tyrosine-protein kinase SYK isoform 1 (mouse)

mSYK/iso:1


"A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000025834

tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)

mSYK/iso:1/Phos:1


"A tyrosine-protein kinase SYK isoform 1 phosphorylated 1 in mouse. UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:JAN]

Yes

organism-modification



PR:000049791

tyrosine-protein kinase SYK isoform 1 phosphorylated 2 (mouse)

mSYK/iso:1/Phos:2


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342. UniProtKB:P48025-1, Tyr-342, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049792

tyrosine-protein kinase SYK isoform 1 unphosphorylated 2 (mouse)

mSYK/iso:1/UnPhos:2


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 342. UniProtKB:P48025-1, Tyr-342, PR:000026291." [PMID:27609517, PRO:LN]


organism-modification



PR:000049793

tyrosine-protein kinase SYK isoform 1 phosphorylated 3 (mouse)

mSYK/iso:1/Phos:3


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-346. UniProtKB:P48025-1, Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049794

tyrosine-protein kinase SYK isoform 1 unphosphorylated 3 (mouse)

mSYK/iso:1/UnPhos:3


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 346. UniProtKB:P48025-1, Tyr-346, PR:000026291." [PMID:27609517, PRO:LN]


organism-modification



PR:000049795

tyrosine-protein kinase SYK isoform 1 phosphorylated 4 (mouse)

mSYK/iso:1/Phos:4


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342 and Tyr-346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049796

tyrosine-protein kinase SYK isoform 1 phosphorylated 5 (mouse)

mSYK/iso:1/Phos:5


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342, Tyr-346, Tyr-519 and Tyr-520. UniProtKB:P48025-1, Tyr-342/Tyr-346/Tyr-519/Tyr-520, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049800

tyrosine-protein kinase SYK isoform 1 phosphorylated 6 (mouse)

mSYK/iso:1/Phos:6


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at positions 519 and 520, but it is still phosphorylated at Tyr 342 and 346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048|Tyr-519/Tyr-520, PR:000026291." [PMID:27609517, PRO:LN]


modification



PR:000025833

tyrosine-protein kinase SYK isoform 1 phosphorylated 1

SYK/iso:1/Phos:1


"A tyrosine-protein kinase SYK isoform 1 that has been phosphorylated on several Tyr residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lyn. Example: UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:CNA, PRO:DAN]


organism-modification



PR:000025834

tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)

mSYK/iso:1/Phos:1


"A tyrosine-protein kinase SYK isoform 1 phosphorylated 1 in mouse. UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:JAN]

Yes

modification



PR:000026193

tyrosine-protein kinase SYK phosphorylated 2

SYK/Phos:2


"A tyrosine-protein kinase SYK that has been phosphorylated on a Tyr residue by autocatalysis. Example: UniProtKB:P43405-1, Tyr-348, MOD:00048." [PRO:CNx, Reactome:R-HSA-437953]


organism-modification



PR:000026221

tyrosine-protein kinase SYK phosphorylated 2 (human)

hSYK/Phos:2


"A tyrosine-protein kinase SYK phosphorylated 2 in human. UniProtKB:P43405, Tyr-348, MOD:00048." [PRO:CNx, Reactome:R-HSA-437953]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025834 mSYK/iso:1/Phos:1
UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048
acts_upstream_of_or_withinGO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis PMID:15536084
enablesGO:0019901 protein kinase binding with PR:P09769 FGR PMID:15536084
GO:0031625 ubiquitin protein ligase binding PMID:15536084
GO:0043548 phosphatidylinositol 3-kinase binding PMID:15536084
PR:000036629 hZAP70/iso:1/Phos:1 acts_upstream_of_or_withinGO:0090630 activation of GTPase activity PMID:9269777