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Protein Ontology report - tyrosine-protein kinase SYK
PR:000003065 - http://purl.obolibrary.org/obo/PR_000003065
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003065   
  PRO nametyrosine-protein kinase SYK 
  Synonyms
PRO-Short-label: EXACT:SYK
Other: EXACT:spleen tyrosine kinase
  Definition"A SYK/ZAP-70 family tyrosine-protein kinase that is a translation product of the human SYK gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000003063 SYK/ZAP-70 family tyrosine-protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification2                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2230
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000003065

tyrosine-protein kinase SYK

SYK


"A SYK/ZAP-70 family tyrosine-protein kinase that is a translation product of the human SYK gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:F1N9Y5

tyrosine-protein kinase SYK (chicken)

chick-SYK


"A tyrosine-protein kinase SYK that is encoded in the genome of chicken." [OMA:F1N9Y5, PRO:DNx]


organism-gene



PR:P43405

tyrosine-protein kinase SYK (human)

hSYK


"A tyrosine-protein kinase SYK that is encoded in the genome of human." [PRO:CNA, UniProtKB:P43405]


organism-sequence



PR:P43405-1

tyrosine-protein kinase SYK isoform Long (human)

hSYK/iso:Long


"A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P43405-2

tyrosine-protein kinase SYK isoform Short (human)

hSYK/iso:Short


"A tyrosine-protein kinase SYK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43405-2." [PRO:DNx, UniProtKB:P43405]


organism-modification



PR:000049392

tyrosine-protein kinase SYK phosphotyrosine form (human)

hSYK/PhosTyr+


"A tyrosine-protein kinase SYK (human) that includes at least one phosphorylated tyrosine. UniProtKB:P43405, MOD:00048." [PRO:DNx, Reactome:R-HSA-429432]


organism-modification



PR:000026221

tyrosine-protein kinase SYK phosphorylated 2 (human)

hSYK/Phos:2


"A tyrosine-protein kinase SYK phosphorylated 2 in human. UniProtKB:P43405, Tyr-348, MOD:00048." [PRO:CNx, Reactome:R-HSA-437953]


organism-modification



PR:000049391

tyrosine-protein kinase SYK phosphorylated 3 (human)

hSYK/Phos:3


"A tyrosine-protein kinase SYK (human) that has been post-translationally modified to include phosphotyrosine at positions 131, 323, 348, 352, 525 and 526 of the amino acid sequence represented by UniProtKB:P43405. UniProtKB:P43405, Tyr-131/Tyr-323/Tyr-348/Tyr-352/Tyr-525/Tyr-526, MOD:00048." [PRO:DNx, Reactome:R-HSA-1861712]


organism-modification



PR:000070011

tyrosine-protein kinase SYK cysteinylated 1 (human)

hSYK/Cyst:1


"A tyrosine-protein kinase SYK (human) that has been cysteinylated on the residue at the position equivalent to Cys-608 of the amino acid sequence represented by UniProtKB:P43405-1. Example: UniProtKB:P43405-1, Cys-608, MOD:00765." [IEDB_epitope:1564625, PRO:DNx]


organism-modification



PR:000071958

tyrosine-protein kinase SYK deaminated 1 (human)

hSYK/Deam:1


"A tyrosine-protein kinase SYK (human) that has been deaminated on the residue at the position equivalent to Asn-499 of the amino acid sequence represented by UniProtKB:P43405-1. Example: UniProtKB:P43405-1, Asn-499, MOD:00684." [IEDB_epitope:1583099, PRO:DNx]


organism-gene



PR:P48025

tyrosine-protein kinase SYK (mouse)

mSYK


"A tyrosine-protein kinase SYK that is encoded in the genome of mouse." [OMA:P48025, PRO:DNx]


organism-sequence



PR:P48025-1

tyrosine-protein kinase SYK isoform 1 (mouse)

mSYK/iso:1


"A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000025834

tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)

mSYK/iso:1/Phos:1


"A tyrosine-protein kinase SYK isoform 1 phosphorylated 1 in mouse. UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:JAN]

Yes

organism-modification



PR:000049791

tyrosine-protein kinase SYK isoform 1 phosphorylated 2 (mouse)

mSYK/iso:1/Phos:2


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342. UniProtKB:P48025-1, Tyr-342, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049792

tyrosine-protein kinase SYK isoform 1 unphosphorylated 2 (mouse)

mSYK/iso:1/UnPhos:2


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 342. UniProtKB:P48025-1, Tyr-342, PR:000026291." [PMID:27609517, PRO:LN]


organism-modification



PR:000049793

tyrosine-protein kinase SYK isoform 1 phosphorylated 3 (mouse)

mSYK/iso:1/Phos:3


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-346. UniProtKB:P48025-1, Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049794

tyrosine-protein kinase SYK isoform 1 unphosphorylated 3 (mouse)

mSYK/iso:1/UnPhos:3


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 346. UniProtKB:P48025-1, Tyr-346, PR:000026291." [PMID:27609517, PRO:LN]


organism-modification



PR:000049795

tyrosine-protein kinase SYK isoform 1 phosphorylated 4 (mouse)

mSYK/iso:1/Phos:4


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342 and Tyr-346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049796

tyrosine-protein kinase SYK isoform 1 phosphorylated 5 (mouse)

mSYK/iso:1/Phos:5


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342, Tyr-346, Tyr-519 and Tyr-520. UniProtKB:P48025-1, Tyr-342/Tyr-346/Tyr-519/Tyr-520, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049800

tyrosine-protein kinase SYK isoform 1 phosphorylated 6 (mouse)

mSYK/iso:1/Phos:6


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at positions 519 and 520, but it is still phosphorylated at Tyr 342 and 346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048|Tyr-519/Tyr-520, PR:000026291." [PMID:27609517, PRO:LN]


organism-gene



PR:Q64725

tyrosine-protein kinase SYK (rat)

rSYK


"A tyrosine-protein kinase SYK that is encoded in the genome of rat." [OMA:Q64725, PRO:DNx]


organism-sequence



PR:Q64725-1

tyrosine-protein kinase SYK isoform SykB (rat)

rSYK/iso:SykB


"A tyrosine-protein kinase SYK (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64725-1." [PRO:DNx, UniProtKB:Q64725]


organism-sequence



PR:Q64725-2

tyrosine-protein kinase SYK isoform SykA (rat)

rSYK/iso:SykA


"A tyrosine-protein kinase SYK (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64725-2." [PRO:DNx, UniProtKB:Q64725]


sequence



PR:000025832

tyrosine-protein kinase SYK isoform 1

SYK/iso:1


"A tyrosine-protein kinase SYK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48025-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P43405-1

tyrosine-protein kinase SYK isoform Long (human)

hSYK/iso:Long


"A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P48025-1

tyrosine-protein kinase SYK isoform 1 (mouse)

mSYK/iso:1


"A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000025834

tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)

mSYK/iso:1/Phos:1


"A tyrosine-protein kinase SYK isoform 1 phosphorylated 1 in mouse. UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:JAN]

Yes

organism-modification



PR:000049791

tyrosine-protein kinase SYK isoform 1 phosphorylated 2 (mouse)

mSYK/iso:1/Phos:2


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342. UniProtKB:P48025-1, Tyr-342, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049792

tyrosine-protein kinase SYK isoform 1 unphosphorylated 2 (mouse)

mSYK/iso:1/UnPhos:2


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 342. UniProtKB:P48025-1, Tyr-342, PR:000026291." [PMID:27609517, PRO:LN]


organism-modification



PR:000049793

tyrosine-protein kinase SYK isoform 1 phosphorylated 3 (mouse)

mSYK/iso:1/Phos:3


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-346. UniProtKB:P48025-1, Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049794

tyrosine-protein kinase SYK isoform 1 unphosphorylated 3 (mouse)

mSYK/iso:1/UnPhos:3


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 346. UniProtKB:P48025-1, Tyr-346, PR:000026291." [PMID:27609517, PRO:LN]


organism-modification



PR:000049795

tyrosine-protein kinase SYK isoform 1 phosphorylated 4 (mouse)

mSYK/iso:1/Phos:4


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342 and Tyr-346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049796

tyrosine-protein kinase SYK isoform 1 phosphorylated 5 (mouse)

mSYK/iso:1/Phos:5


"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342, Tyr-346, Tyr-519 and Tyr-520. UniProtKB:P48025-1, Tyr-342/Tyr-346/Tyr-519/Tyr-520, MOD:00048." [PMID:27609517, PRO:LN]


organism-modification



PR:000049800

tyrosine-protein kinase SYK isoform 1 phosphorylated 6 (mouse)

mSYK/iso:1/Phos:6


"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at positions 519 and 520, but it is still phosphorylated at Tyr 342 and 346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048|Tyr-519/Tyr-520, PR:000026291." [PMID:27609517, PRO:LN]


modification



PR:000025833

tyrosine-protein kinase SYK isoform 1 phosphorylated 1

SYK/iso:1/Phos:1


"A tyrosine-protein kinase SYK isoform 1 that has been phosphorylated on several Tyr residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lyn. Example: UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:CNA, PRO:DAN]


organism-modification



PR:000025834

tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)

mSYK/iso:1/Phos:1


"A tyrosine-protein kinase SYK isoform 1 phosphorylated 1 in mouse. UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:JAN]

Yes

modification



PR:000026193

tyrosine-protein kinase SYK phosphorylated 2

SYK/Phos:2


"A tyrosine-protein kinase SYK that has been phosphorylated on a Tyr residue by autocatalysis. Example: UniProtKB:P43405-1, Tyr-348, MOD:00048." [PRO:CNx, Reactome:R-HSA-437953]


organism-modification



PR:000026221

tyrosine-protein kinase SYK phosphorylated 2 (human)

hSYK/Phos:2


"A tyrosine-protein kinase SYK phosphorylated 2 in human. UniProtKB:P43405, Tyr-348, MOD:00048." [PRO:CNx, Reactome:R-HSA-437953]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025834 mSYK/iso:1/Phos:1
UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048
acts_upstream_of_or_withinGO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis PMID:15536084
enablesGO:0019901 protein kinase binding with PR:P09769 FGR PMID:15536084
GO:0031625 ubiquitin protein ligase binding PMID:15536084
GO:0043548 phosphatidylinositol 3-kinase binding PMID:15536084