back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - apoptosis regulator Bcl-2 isoform 1 phosphorylated form
PR:000003088 - http://purl.obolibrary.org/obo/PR_000003088
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003088   
  PRO nameapoptosis regulator Bcl-2 isoform 1 phosphorylated form 
  Synonyms
PRO-Short-label: EXACT:BCL2/iso:1/PhosRes+
  Definition"An apoptosis regulator Bcl-2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] 
  PRO Categorymodification 
  ParentPR:000002383 apoptosis regulator Bcl-2 isoform 1
PR:000037070 phosphoprotein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification6                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000003088
apoptosis regulator Bcl-2 isoform 1 phosphorylated form
BCL2/iso:1/PhosRes+
"An apoptosis regulator Bcl-2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000003089
apoptosis regulator Bcl-2 isoform 1 phosphorylated 1
BCL2/iso:1/Phos:1
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs by the action of PKC. Example: UniProtKB:P10417-1, Ser-70, MOD:00046." [PMID:9115213, PMID:9852076, PRO:JAN]

organism-modification


PR:000036633
apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 (mouse)
mBCL2/iso:1/Phos:1
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 in mouse. UniProtKB:P10417-1, Ser-70, MOD:00046." [PMID:9115213, PMID:9852076, PRO:JAN]
Yes
modification


PR:000027460
apoptosis regulator Bcl-2 isoform 1 phosphorylated 2
BCL2/iso:1/Phos:2
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs on a Thr residue within the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]

organism-modification


PR:000027461
apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)
hBCL2/iso:1/Phos:2
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 in human. UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]
Yes
modification


PR:000027462
apoptosis regulator Bcl-2 isoform 1 phosphorylated 3
BCL2/iso:1/Phos:3
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs at the three major phosphorylation sites (Thr and two conserved Ser residues) within the motif TSPLx(7-10)GPxLS, which is part of the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]

organism-modification


PR:000027463
apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)
hBCL2/iso:1/Phos:3
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]
Yes
modification


PR:000027464
apoptosis regulator Bcl-2 isoform 1 phosphorylated 4
BCL2/iso:1/Phos:4
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Thr and second Ser residue within the motif TSPLx(7-10)GPxLS, which is part of the the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]

organism-modification


PR:000027465
apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)
hBCL2/iso:1/Phos:4
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]
Yes
modification


PR:000027466
apoptosis regulator Bcl-2 isoform 1 phosphorylated 5
BCL2/iso:1/Phos:5
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser or Thr of the [TS]PxP motif, which is part of the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]

organism-modification


PR:000027467
apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)
hBCL2/iso:1/Phos:5
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 in human. UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]
Yes
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027461 hBCL2/iso:1/Phos:2
UniProtKB:P10415-1, Thr-74, MOD:00047		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:12039864
PR:000027463 hBCL2/iso:1/Phos:3
UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046		 acts_upstream_of_or_withinGO:0016239 positive regulation of macroautophagy PMID:18570871; PMID:19029119
enablesNOT GO:0005515 protein binding with PR:Q14457 BECN1 PMID:18570871; PMID:19029119
PR:000027465 hBCL2/iso:1/Phos:4
UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046		 acts_upstream_of_or_withinGO:0043065 positive regulation of apoptotic process PMID:15703383
PR:000027467 hBCL2/iso:1/Phos:5
UniProtKB:P10415-1, Thr-56, MOD:00047		 acts_upstream_of_or_withinGO:0045839 negative regulation of mitotic nuclear division PMID:10766756
PR:000036633 mBCL2/iso:1/Phos:1
UniProtKB:P10417-1, Ser-70, MOD:00046		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:9115213; PMID:9852076
enablesGO:0005515 protein binding with PR:Q07813 Bax PMID:9115213; PMID:9852076
GO:0019902 phosphatase binding PMID:9115213; PMID:9852076
located_inGO:0016020 membrane PMID:9115213; PMID:9852076