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Protein Ontology report - mitogen-activated protein kinase 14
PR:000003107 - http://purl.obolibrary.org/obo/PR_000003107
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003107   
  PRO namemitogen-activated protein kinase 14 
  Synonyms
PRO-Short-label: EXACT:MAPK14
Gene-based: RELATED:CSBP | CSBP1 | CSBP2 | CSPB1 | MXI2 | SAPK2A
Other: EXACT:CRK1 | CSAID-binding protein | cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAX-interacting protein 2 | mitogen-activated protein kinase p38 alpha
  Definition"A map kinase p38 that is a translation product of the human MAPK14 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000003106 map kinase p38
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence2                                                  Organism-Sequence 9                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1499
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000003107
mitogen-activated protein kinase 14
MAPK14
"A map kinase p38 that is a translation product of the human MAPK14 gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P47811
mitogen-activated protein kinase 14 (mouse)
mMAPK14
"A mitogen-activated protein kinase 14 that is encoded in the genome of mouse." [OMA:P47811, PRO:DNx]

organism-sequence


PR:P47811-1
mitogen-activated protein kinase 14 isoform 1 (mouse)
mMAPK14/iso:1
"A mitogen-activated protein kinase 14 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
Yes
organism-sequence


PR:P47811-2
mitogen-activated protein kinase 14 isoform m2 (mouse)
mMAPK14/iso:m2
"A mitogen-activated protein kinase 14 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P47811-2." [PRO:DNx, UniProtKB:P47811]

organism-sequence


PR:P47811-3
mitogen-activated protein kinase 14 isoform 3 (mouse)
mMAPK14/iso:3
"A mitogen-activated protein kinase 14 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]

organism-sequence


PR:P47811-4
mitogen-activated protein kinase 14 isoform m4 (mouse)
mMAPK14/iso:m4
"A mitogen-activated protein kinase 14 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P47811-4." [PRO:DNx, UniProtKB:P47811]

organism-gene


PR:Q16539
mitogen-activated protein kinase 14 (human)
hMAPK14
"A mitogen-activated protein kinase 14 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q16539]

organism-sequence


PR:Q16539-1
mitogen-activated protein kinase 14 isoform CSBP2 (human)
hMAPK14/iso:CSBP2
"A mitogen-activated protein kinase 14 isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-sequence


PR:Q16539-2
mitogen-activated protein kinase 14 isoform CSBP1 (human)
hMAPK14/iso:CSBP1
"A mitogen-activated protein kinase 14 isoform 2 that is encoded in the genome of human." [PRO:DNx]

organism-sequence


PR:Q16539-3
mitogen-activated protein kinase 14 isoform hMxi2 (human)
hMAPK14/iso:hMxi2
"A mitogen-activated protein kinase 14 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16539-3." [PRO:DNx, UniProtKB:Q16539]

organism-sequence


PR:Q16539-4
mitogen-activated protein kinase 14 isoform Exip (human)
hMAPK14/iso:Exip
"A mitogen-activated protein kinase 14 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16539-4." [PRO:DNx, UniProtKB:Q16539]

organism-sequence


PR:Q16539-5
mitogen-activated protein kinase 14 isoform h5 (human)
hMAPK14/iso:h5
"A mitogen-activated protein kinase 14 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16539-5." [PRO:DNx, UniProtKB:Q16539]

organism-modification


PR:000036637
mitogen-activated protein kinase 14 phosphorylated 1 (human)
hMAPK14/Phos:1
"A mitogen-activated protein kinase 14 phosphorylated 1 in human. Example: UniProtKB:Q16539-1, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PMID:15642743, PRO:CL]
Yes
organism-modification


PR:000048319
mitogen-activated protein kinase 14, initiator methionine removed form (human)
hMAPK14/InitMet-
"A mitogen-activated protein kinase 14 (human) that has had the initiator methionine removed. UniProtKB:Q16539, 2-360." [PRO:DNx, Reactome:R-HSA-428933, Reactome:R-HSA-446223]

organism-modification


PR:000048320
mitogen-activated protein kinase 14, initiator methionine removed phosphorylated 1 (human)
hMAPK14/InitMet-/Phos:1
"A mitogen-activated protein kinase 14 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 180, and phosphotyrosine at position 182 of the amino acid sequence represented by UniProtKB:Q16539. UniProtKB:Q16539, 2-360, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PRO:DNx, Reactome:R-HSA-428935, Reactome:R-HSA-446227]

organism-modification


PR:000067949
mitogen-activated protein kinase 14 deaminated 1 (human)
hMAPK14/Deam:1
"A mitogen-activated protein kinase 14 (human) that has been deaminated on the residue at the position equivalent to Gln-325 of the amino acid sequence represented by UniProtKB:Q16539-1. Example: UniProtKB:Q16539-1, Gln-325, MOD:00685." [IEDB_epitope:1976216, PRO:DNx]

sequence


PR:000040708
mitogen-activated protein kinase 14 isoform 1
MAPK14/iso:1
"A mitogen-activated protein kinase 14 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16539-1 or a 1:1 ortholog thereof." [PRO:DNx]

organism-sequence


PR:P47811-1
mitogen-activated protein kinase 14 isoform 1 (mouse)
mMAPK14/iso:1
"A mitogen-activated protein kinase 14 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
Yes
organism-sequence


PR:Q16539-1
mitogen-activated protein kinase 14 isoform CSBP2 (human)
hMAPK14/iso:CSBP2
"A mitogen-activated protein kinase 14 isoform 1 that is encoded in the genome of human." [PRO:DNx]

sequence


PR:000040709
mitogen-activated protein kinase 14 isoform 2
MAPK14/iso:2
"A mitogen-activated protein kinase 14 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16539-2 or a 1:1 ortholog thereof." [PRO:DNx]

organism-sequence


PR:P47811-3
mitogen-activated protein kinase 14 isoform 3 (mouse)
mMAPK14/iso:3
"A mitogen-activated protein kinase 14 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]

organism-sequence


PR:Q16539-2
mitogen-activated protein kinase 14 isoform CSBP1 (human)
hMAPK14/iso:CSBP1
"A mitogen-activated protein kinase 14 isoform 2 that is encoded in the genome of human." [PRO:DNx]

modification


PR:000003108
mitogen-activated protein kinase 14 phosphorylated form
MAPK14/PhosRes+
"A mitogen-activated protein kinase 14 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000003109
mitogen-activated protein kinase 14 phosphorylated 1
MAPK14/Phos:1
"A mitogen-activated protein kinase 14 that has been phosphorylated on residues at positions equivalent to Thr-180 and Tyr-182 of the amino acid sequence represented by UniProtKB:Q16539-1. Example: UniProtKB:Q16539-1, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PMID:15642743, PRO:CL, PRO:DAN]

organism-modification


PR:000036637
mitogen-activated protein kinase 14 phosphorylated 1 (human)
hMAPK14/Phos:1
"A mitogen-activated protein kinase 14 phosphorylated 1 in human. Example: UniProtKB:Q16539-1, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PMID:15642743, PRO:CL]
Yes
organism-modification


PR:000048320
mitogen-activated protein kinase 14, initiator methionine removed phosphorylated 1 (human)
hMAPK14/InitMet-/Phos:1
"A mitogen-activated protein kinase 14 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 180, and phosphotyrosine at position 182 of the amino acid sequence represented by UniProtKB:Q16539. UniProtKB:Q16539, 2-360, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PRO:DNx, Reactome:R-HSA-428935, Reactome:R-HSA-446227]

modification


PR:000018784
mitogen-activated protein kinase 14, initiator methionine removed form
MAPK14/InitMet-
"A mitogen-activated protein kinase 14 that has had the initiator methionine removed." [PRO:DNx]

organism-modification


PR:000048319
mitogen-activated protein kinase 14, initiator methionine removed form (human)
hMAPK14/InitMet-
"A mitogen-activated protein kinase 14 (human) that has had the initiator methionine removed. UniProtKB:Q16539, 2-360." [PRO:DNx, Reactome:R-HSA-428933, Reactome:R-HSA-446223]

organism-modification


PR:000048320
mitogen-activated protein kinase 14, initiator methionine removed phosphorylated 1 (human)
hMAPK14/InitMet-/Phos:1
"A mitogen-activated protein kinase 14 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 180, and phosphotyrosine at position 182 of the amino acid sequence represented by UniProtKB:Q16539. UniProtKB:Q16539, 2-360, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PRO:DNx, Reactome:R-HSA-428935, Reactome:R-HSA-446227]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036637 hMAPK14/Phos:1
Example: UniProtKB:Q16539-1, Thr-180, MOD:00047|Tyr-182, MOD:00048		 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:15642743
enablesGO:0004707 MAP kinase activity PMID:15642743
GO:0005515 protein binding PMID:15642743
PR:P47811-1 mMAPK14/iso:1 acts_upstream_of_or_withinGO:0014835 myoblast differentiation involved in skeletal muscle regeneration MGI_ref:4838005; PMID:20610565