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Protein Ontology report - furin
PR:000003137 - http://purl.obolibrary.org/obo/PR_000003137
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000003137   
  PRO namefurin 
  Synonyms
PRO-Short-label: EXACT:FURIN
Gene-based: RELATED:FUR | PACE | PCSK3
Other: EXACT:dibasic-processing enzyme | paired basic amino acid residue-cleaving enzyme
RELATED:prohormone convertase 3
  Definition"A subtilisin/kexin-type proprotein convertase that is a translation product of the human FURIN gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000003136 subtilisin/kexin-type proprotein convertase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2366
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000003137

furin

FURIN


"A subtilisin/kexin-type proprotein convertase that is a translation product of the human FURIN gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O17798

furin-like protease kpc-1 (worm)

FURIN (worm)


"A furin that is encoded in the genome of worm." [OMA:O17798, PRO:CNA]


organism-gene



PR:P09958

furin (human)

hFURIN


"A furin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P09958]


organism-sequence



PR:P09958-1

furin isoform 1 (human)

hFURIN/iso:1


"A furin isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000035903

furin active form (human)

hFURIN/active


"A furin active form in human. UniProtKB:P09958, 108-794." [PMID:1629222, Reactome:R-HSA-1181103, Reactome:R-HSA-157049, Reactome:R-HSA-2159856, Reactome:R-HSA-448351]


organism-modification



PR:000082386

furin cysteinylated 1 (human)

hFURIN/Cyst:1


"A furin (human) that has been cysteinylated on the residue at the position equivalent to Cys-450 of the amino acid sequence represented by UniProtKB:P09958. UniProtKB:P09958, Cys-450, MOD:00765." [IEDB_epitope:2117361, PRO:DNx]


organism-gene



PR:P23188

furin (mouse)

mFURIN


"A furin that is encoded in the genome of mouse." [OMA:P23188, PRO:DNx]


organism-sequence



PR:P23188-1

furin isoform 1 (mouse)

mFURIN/iso:1


"A furin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:P23377

furin (rat)

rFURIN


"A furin that is encoded in the genome of rat." [OMA:P23377, PRO:DNx]


sequence



PR:000003147

furin isoform 1

FURIN/iso:1


"A furin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09958-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P09958-1

furin isoform 1 (human)

hFURIN/iso:1


"A furin isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P23188-1

furin isoform 1 (mouse)

mFURIN/iso:1


"A furin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000018787

furin proteolytic cleavage product

FURIN/ClvPrd


"A furin that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000021921

furin, signal peptide removed form

FURIN/SigPep-


"A furin that has had the signal peptide removed." [PRO:DNx]


modification



PR:000003150

furin active form

FURIN/active


"A furin, signal peptide removed form that has been processed by subsequent removal of the inhibition peptide." [PRO:DAN]


modification



PR:000003151

furin active form phosphorylated form

FURIN/active/PhosRes+


"A furin active form that includes at least one phosphorylated residue." [PRO:CNA, PRO:DAN]


modification



PR:000003152

furin active form phosphorylated 1

FURIN/active/Phos:1


"A furin active form phosphorylated form in which the phosphorylation occurs at two Ser residues located in the acid cytoplasmic tail. Phosphorylation of mature furin is required for TGN localization of the endoprotease. Example: UniProtKB:P09958-1, 108-794, Ser-773/Ser-775, MOD:00046." [PMID:8846780, UniProtKB:P09958]


organism-modification



PR:000035903

furin active form (human)

hFURIN/active


"A furin active form in human. UniProtKB:P09958, 108-794." [PMID:1629222, Reactome:R-HSA-1181103, Reactome:R-HSA-157049, Reactome:R-HSA-2159856, Reactome:R-HSA-448351]