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Protein Ontology report - protein pellino
PR:000003140 - http://purl.obolibrary.org/obo/PR_000003140
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003140   
  PRO nameprotein pellino 
  Definition"A protein that is the stand-alone version of the Pellino (Pfam:PF04710) domain. Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase." [Pfam:PF04710
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 6                                        
         Sequence3                                                  Organism-Sequence 10                                        
         Modification3                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038886
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000003140

protein pellino

TRAF6/iso:1/K63polyUbiq:1


"A protein that is the stand-alone version of the Pellino (Pfam:PF04710) domain. Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase." [Pfam:PF04710]


gene



PR:000003141

E3 ubiquitin-protein ligase pellino homolog 1

PELI1


"A protein pellino that is a translation product of the human PELI1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q8C669

E3 ubiquitin-protein ligase pellino homolog 1 (mouse)

mPELI1


"An E3 ubiquitin-protein ligase pellino homolog 1 that is encoded in the genome of mouse." [OMA:Q8C669, PRO:CNA]


Yes
organism-sequence



PR:Q8C669-1

E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 (mouse)

mPELI1/iso:1


"An E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q96FA3

E3 ubiquitin-protein ligase pellino homolog 1 (human)

hPELI1


"An E3 ubiquitin-protein ligase pellino homolog 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96FA3]


organism-sequence



PR:Q96FA3-1

E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 (human)

hPELI1/iso:1


"An E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000027047

E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1 (human)

hPELI1/iso:1/Phos:1


"An E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1 in human." [PMID:19264966, PRO:CNA]


organism-modification



PR:000063871

E3 ubiquitin-protein ligase pellino homolog 1 phosphorylated form (human)

hPELI1/PhosRes+


"An E3 ubiquitin-protein ligase pellino homolog 1 (human) that includes at least one phosphorylated residue. UniProtKB:Q96FA3, MOD:00696." [PRO:DNx, Reactome:R-HSA-450815]


organism-modification



PR:000064634

E3 ubiquitin-protein ligase pellino homolog 1 phosphorylated 1 (human)

hPELI1/Phos:1


"An E3 ubiquitin-protein ligase pellino homolog 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-39 of the amino acid sequence represented by UniProtKB:Q96FA3. UniProtKB:Q96FA3, Ser-39, MOD:00046." [IEDB_epitope:611631, PRO:DNx]


organism-modification



PR:000075404

E3 ubiquitin-protein ligase pellino homolog 1 methylated 1 (human)

hPELI1/Me:1


"An E3 ubiquitin-protein ligase pellino homolog 1 (human) that has been methylated on the residue at the position equivalent to Cys-61 of the amino acid sequence represented by UniProtKB:Q96FA3. UniProtKB:Q96FA3, Cys-61, MOD:00660." [IEDB_epitope:1004337, PRO:DNx]


organism-modification



PR:000075594

E3 ubiquitin-protein ligase pellino homolog 1 methylated 2 (human)

hPELI1/Me:2


"An E3 ubiquitin-protein ligase pellino homolog 1 (human) that has been methylated on the residue at the position equivalent to Cys-282 of the amino acid sequence represented by UniProtKB:Q96FA3. UniProtKB:Q96FA3, Cys-282, MOD:00660." [IEDB_epitope:1044348, PRO:DNx]


sequence



PR:000003142

E3 ubiquitin-protein ligase pellino homolog 1 isoform 1

PELI1/iso:1


"An E3 ubiquitin-protein ligase pellino homolog 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C669-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q8C669-1

E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 (mouse)

mPELI1/iso:1


"An E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q96FA3-1

E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 (human)

hPELI1/iso:1


"An E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000027047

E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1 (human)

hPELI1/iso:1/Phos:1


"An E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1 in human." [PMID:19264966, PRO:CNA]


modification



PR:000003144

E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated form

PELI1/iso:1/PhosRes+


"An E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003145

E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1

PELI1/iso:1/Phos:1


"An E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated form in which the phosphorylation occurs at the seven residues whose phosphorylation are critical for activation. Five of these residues are located in the region of antiparallel beta-sheet, termed the wing; whereas the other two are just N-terminal to the RING-like domain that carries the E3 ligase activity." [PMID:19264966, TLR:AMM]


organism-modification



PR:000027047

E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1 (human)

hPELI1/iso:1/Phos:1


"An E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1 in human." [PMID:19264966, PRO:CNA]


gene



PR:000012539

E3 ubiquitin-protein ligase pellino homolog 2

PELI2


"A protein pellino that is a translation product of the human PELI2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q8BST6

E3 ubiquitin-protein ligase pellino homolog 2 (mouse)

mPELI2


"An E3 ubiquitin-protein ligase pellino homolog 2 that is encoded in the genome of mouse." [OMA:Q8BST6, PRO:DNx]


organism-sequence



PR:Q8BST6-1

E3 ubiquitin-protein ligase pellino homolog 2 isoform m1 (mouse)

mPELI2/iso:m1


"An E3 ubiquitin-protein ligase pellino homolog 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BST6-1." [PRO:DNx, UniProtKB:Q8BST6]


organism-sequence



PR:Q8BST6-2

E3 ubiquitin-protein ligase pellino homolog 2 isoform m2 (mouse)

mPELI2/iso:m2


"An E3 ubiquitin-protein ligase pellino homolog 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BST6-2." [PRO:DNx, UniProtKB:Q8BST6]


organism-sequence



PR:Q8BST6-3

E3 ubiquitin-protein ligase pellino homolog 2 isoform m3 (mouse)

mPELI2/iso:m3


"An E3 ubiquitin-protein ligase pellino homolog 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BST6-3." [PRO:DNx, UniProtKB:Q8BST6]


organism-gene



PR:Q9HAT8

E3 ubiquitin-protein ligase pellino homolog 2 (human)

hPELI2


"An E3 ubiquitin-protein ligase pellino homolog 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HAT8]


organism-modification



PR:000048741

E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated form (human)

hPELI2/PhosRes+


"An E3 ubiquitin-protein ligase pellino homolog 2 (human) that includes at least one phosphorylated residue. UniProtKB:Q9HAT8, MOD:00696." [PRO:DNx, Reactome:R-HSA-450825]


organism-modification



PR:000027058

E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated 1 (human)

hPELI2/Phos:1


"An E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated 1 in human. This is the active form and it is phosphorylated at least in a critical Thr residue. UniProtKB:Q9HAT8, Thr-290, MOD:00047." [PMID:19264966, PRO:CNA]

Yes

modification



PR:000027055

E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated 1

PELI2/Phos:1


"An E3 ubiquitin-protein ligase pellino homolog 2 that has been phosphorylated by IRAK1. Example: UniProtKB:Q9HAT8, Thr-290, MOD:00047." [PRO:CNA, PRO:DAN]


organism-modification



PR:000027058

E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated 1 (human)

hPELI2/Phos:1


"An E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated 1 in human. This is the active form and it is phosphorylated at least in a critical Thr residue. UniProtKB:Q9HAT8, Thr-290, MOD:00047." [PMID:19264966, PRO:CNA]

Yes

gene



PR:000012540

E3 ubiquitin-protein ligase pellino homolog 3

PELI3


"A protein pellino that is a translation product of the human PELI3 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q8BXR6

E3 ubiquitin-protein ligase pellino homolog 3 (mouse)

mPELI3


"An E3 ubiquitin-protein ligase pellino homolog 3 that is encoded in the genome of mouse." [OMA:Q8BXR6, PRO:CNA]


organism-sequence



PR:Q8BXR6-1

E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 (mouse)

mPELI3/iso:2


"An E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 that is encoded in the genome of mouse." [PMID:15489334, PRO:CNA]


organism-gene



PR:Q8N2H9

E3 ubiquitin-protein ligase pellino homolog 3 (human)

hPELI3


"An E3 ubiquitin-protein ligase pellino homolog 3 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8N2H9-1

E3 ubiquitin-protein ligase pellino homolog 3 isoform 1 (human)

hPELI3/iso:1


"An E3 ubiquitin-protein ligase pellino homolog 3 isoform 1 that is encoded in the genome of human." [PMID:12874243, PRO:CNA]


organism-sequence



PR:Q8N2H9-2

E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 (human)

hPELI3/iso:2


"An E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 that is encoded in the genome of human." [PMID:12874243, PRO:CNA]

Yes

organism-sequence



PR:Q8N2H9-3

E3 ubiquitin-protein ligase pellino homolog 3 isoform h3 (human)

hPELI3/iso:h3


"An E3 ubiquitin-protein ligase pellino homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N2H9-3." [PRO:DNx, UniProtKB:Q8N2H9]


organism-sequence



PR:Q8N2H9-4

E3 ubiquitin-protein ligase pellino homolog 3 isoform h4 (human)

hPELI3/iso:h4


"An E3 ubiquitin-protein ligase pellino homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N2H9-4." [PRO:DNx, UniProtKB:Q8N2H9]


organism-modification



PR:000048742

E3 ubiquitin-protein ligase pellino homolog 3 phosphorylated form (human)

hPELI3/PhosRes+


"An E3 ubiquitin-protein ligase pellino homolog 3 (human) that includes at least one phosphorylated residue. UniProtKB:Q8N2H9, MOD:00696." [PRO:DNx, Reactome:R-HSA-450806]


sequence



PR:000027048

E3 ubiquitin-protein ligase pellino homolog 3 isoform 1

PELI3/iso:1


"An E3 ubiquitin-protein ligase pellino homolog 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N2H9-1 or a 1:1 ortholog thereof." [PMID:12874243, PRO:CNA]


organism-sequence



PR:Q8N2H9-1

E3 ubiquitin-protein ligase pellino homolog 3 isoform 1 (human)

hPELI3/iso:1


"An E3 ubiquitin-protein ligase pellino homolog 3 isoform 1 that is encoded in the genome of human." [PMID:12874243, PRO:CNA]


sequence



PR:000027050

E3 ubiquitin-protein ligase pellino homolog 3 isoform 2

PELI3/iso:2


"An E3 ubiquitin-protein ligase pellino homolog 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N2H9-2 or a 1:1 ortholog thereof." [PMID:12874243, PRO:CNA]


organism-sequence



PR:Q8BXR6-1

E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 (mouse)

mPELI3/iso:2


"An E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 that is encoded in the genome of mouse." [PMID:15489334, PRO:CNA]


organism-sequence



PR:Q8N2H9-2

E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 (human)

hPELI3/iso:2


"An E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 that is encoded in the genome of human." [PMID:12874243, PRO:CNA]

Yes

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TRAF6/iso:1/K63polyUbiq:1 forms found in complexes   

TRAF6/iso:1/K63polyUbiq:1 Component
Complexes
PR:Q8C669 mPELI1 PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027058 hPELI2/Phos:1
UniProtKB:Q9HAT8, Thr-290, MOD:00047
located_inGO:0005829 cytosol Reactome:REACT_22715
PR:Q8N2H9-2 hPELI3/iso:2 acts_upstream_of_or_withinGO:0070534 protein K63-linked ubiquitination PMID:18326498
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway PMID:18326498