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Protein Ontology report - RAF proto-oncogene serine/threonine-protein kinase isoform 1
PR:000003245 - http://purl.obolibrary.org/obo/PR_000003245
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003245   
  PRO nameRAF proto-oncogene serine/threonine-protein kinase isoform 1 
  Synonyms
PRO-Short-label: EXACT:RAF1/iso:1
Other: RELATED:RAF-1 isoform 6C
  Definition"A RAF proto-oncogene serine/threonine-protein kinase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04049-1 or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000003244 RAF proto-oncogene serine/threonine-protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification4                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000003245 RAF proto-oncogene serine/threonine-protein kinase isoform 1
RAF1/iso:1

organism-sequence


PR:P04049-1 RAF proto-oncogene serine/threonine-protein kinase isoform 1 (human)
hRAF1/iso:1

organism-modification


PR:000026210 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 (human)
hRAF1/iso:1/Phos:3

organism-modification


PR:000036643 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)
hRAF1/iso:1/Phos:2
Yes
organism-sequence


PR:Q99N57-1 RAF proto-oncogene serine/threonine-protein kinase isoform 1 (mouse)
mRAF1/iso:1

modification


PR:000003247 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated form
RAF1/iso:1/PhosRes+

modification


PR:000003249 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 1
RAF1/iso:1/Phos:1

modification


PR:000003250 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2
RAF1/iso:1/Phos:2

organism-modification


PR:000036643 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)
hRAF1/iso:1/Phos:2
Yes
modification


PR:000026174 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3
RAF1/iso:1/Phos:3

organism-modification


PR:000026210 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 (human)
hRAF1/iso:1/Phos:3

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036643 hRAF1/iso:1/Phos:2
UniProtKB:P04049-1, Ser-338/Ser-339, MOD:00046		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:15849194
enablesGO:0004674 protein serine/threonine kinase activity PMID:15849194
GO:0005515 protein binding PMID:15849194
located_inGO:0005741 mitochondrial outer membrane PMID:15849194