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Protein Ontology report - interferon regulatory factor 3 isoform 1 phosphorylated 1
PR:000003260 - http://purl.obolibrary.org/obo/PR_000003260
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003260   
  PRO nameinterferon regulatory factor 3 isoform 1 phosphorylated 1 
  Synonyms
PRO-Short-label: EXACT:IRF3/iso:1/Phos:1
Other: EXACT:IRF3 active form | phospho IRF3
  Definition"An interferon regulatory factor 3 isoform 1 phosphorylated form in which the phosphorylation occurs upon stimulation by virus infection or treatment with double-stranded RNA or LPS. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. Example: UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046." [PMID:14703513, PMID:20043992, TLR:AMM] 
  CommentRequested by=TLR. 
  PRO Categorymodification 
  ParentPR:000003259 interferon regulatory factor 3 isoform 1 phosphorylated form
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000003260 interferon regulatory factor 3 isoform 1 phosphorylated 1
IRF3/iso:1/Phos:1

organism-modification


PR:000025763 interferon regulatory factor 3 isoform 1 phosphorylated 1 (human)
hIRF3/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000027097 interferon regulatory factor 3 isoform 1 phosphorylated 1 (mouse)
mIRF3/iso:1/Phos:1

Yes
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IRF3/iso:1/Phos:1 forms found in complexes   

IRF3/iso:1/Phos:1 Component
 Complexes
PR:000025763 hIRF3/iso:1/Phos:1 PR:000036002 IRF3-P:IRF3-P:KPNA4 complex (human)
PR:000027097 mIRF3/iso:1/Phos:1 PR:000027098 IRF3-P:IRF3-P complex (mouse)
PR:000036043 IRF3-P:p65 complex (mouse)
PR:000036047 IRF3-P:p65:ISRE complex (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025763 hIRF3/iso:1/Phos:1
UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046		 enablesGO:0005515 protein binding with PR:O14980 chromosome region maintenance 1 protein homolog (human) PMID:10805757
located_inGO:0005829 cytosol Reactome:REACT_7149