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Protein Ontology report - dual specificity mitogen-activated protein kinase kinase 3
PR:000003284 - http://purl.obolibrary.org/obo/PR_000003284
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003284   
  PRO namedual specificity mitogen-activated protein kinase kinase 3 
  Synonyms
PRO-Short-label: EXACT:MAP2K3
Gene-based: RELATED:MEK3 | MKK3 | PRKMK3 | SKK2
Other: EXACT:MAP kinase kinase 3 | MAPK/ERK kinase 3 | MAPKK 3 | MEK 3
  Definition"A dual specificity mitogen-activated protein kinase kinase 3/6 that is a translation product of the human MAP2K3 gene or a 1:1 ortholog thereof." [TLR:AMM] 
  CommentRequested by=TLR. 
  PRO Categorygene 
  ParentPR:000021990 dual specificity mitogen-activated protein kinase kinase 3/6
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 5                                        
         Modification2                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2064
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000003284

dual specificity mitogen-activated protein kinase kinase 3

MAP2K3


"A dual specificity mitogen-activated protein kinase kinase 3/6 that is a translation product of the human MAP2K3 gene or a 1:1 ortholog thereof." [TLR:AMM]


organism-gene



PR:O09110

dual specificity mitogen-activated protein kinase kinase 3 (mouse)

mMAP2K3


"A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of mouse." [OMA:O09110, PRO:DNx]


organism-sequence



PR:O09110-1

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse)

mMAP2K3/iso:2


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 1 that is encoded in the genome of mouse." [TLR:AMM]


organism-modification



PR:000049826

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (mouse)

mMAP2K3/iso:2/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse) that has been phosphorylated at Ser-218. UniProtKB:O09110-1, Ser-218, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049827

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 2 (mouse)

mMAP2K3/iso:2/Phos:2


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse) that has been phosphorylated at Ser-218 and Thr-222. UniProtKB:O09110-1, Ser-218, MOD:00046|Thr-222, MOD:00047." [PMID:21183079, PRO:HJD]


organism-sequence



PR:O09110-2

dual specificity mitogen-activated protein kinase kinase 3 isoform 1 (mouse)

mMAP2K3/iso:1


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:P46734

dual specificity mitogen-activated protein kinase kinase 3 (human)

hMAP2K3


"A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of human." [TLR:AMM, UniProtKB:P46734]


organism-sequence



PR:P46734-1

dual specificity mitogen-activated protein kinase kinase 3 isoform 3 (human)

hMAP2K3/iso:3


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 1 that is encoded in the genome of human." [TLR:AMM]


organism-sequence



PR:P46734-2

dual specificity mitogen-activated protein kinase kinase 3 isoform 1 (human)

hMAP2K3/iso:1


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036646

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (human)

hMAP2K3/iso:2/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 in human. UniProtKB:P46734-2, Ser-189, MOD:00046|Thr-193, MOD:00047." [PMID:8622669, PRO:CNA]

Yes

organism-sequence



PR:P46734-3

dual specificity mitogen-activated protein kinase kinase 3 isoform h2 (human)

hMAP2K3/iso:h2


"A dual specificity mitogen-activated protein kinase kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46734-3." [PRO:DNx, UniProtKB:P46734]


organism-modification



PR:000048297

dual specificity mitogen-activated protein kinase kinase 3 phosphorylated 1 (human)

hMAP2K3/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-218, and phosphothreonine at position 222 of the amino acid sequence represented by UniProtKB:P46734. UniProtKB:P46734, Ser-218, MOD:00046|Thr-222, MOD:00047." [PRO:DNx, Reactome:R-HSA-167955, Reactome:R-HSA-450229]


organism-modification



PR:000075054

dual specificity mitogen-activated protein kinase kinase 3 cysteinylated 1 (human)

hMAP2K3/Cyst:1


"A dual specificity mitogen-activated protein kinase kinase 3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-227 of the amino acid sequence represented by UniProtKB:P46734-1. Example: UniProtKB:P46734-1, Cys-227, MOD:00765." [IEDB_epitope:928198, PRO:DNx]


organism-gene



PR:Q5ZL06

uncharacterized protein, MAP2K3 translation product (chicken)

chick-MAP2K3


"A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of chicken." [PRO:DAN]


sequence



PR:000021942

dual specificity mitogen-activated protein kinase kinase 3 isoform 1

MAP2K3/iso:1


"A dual specificity mitogen-activated protein kinase kinase 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46734-1 or a 1:1 ortholog thereof." [PMID:8900184, TLR:AMM, UniProtKB:P46734-1]


organism-sequence



PR:O09110-1

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse)

mMAP2K3/iso:2


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 1 that is encoded in the genome of mouse." [TLR:AMM]


organism-modification



PR:000049826

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (mouse)

mMAP2K3/iso:2/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse) that has been phosphorylated at Ser-218. UniProtKB:O09110-1, Ser-218, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049827

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 2 (mouse)

mMAP2K3/iso:2/Phos:2


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse) that has been phosphorylated at Ser-218 and Thr-222. UniProtKB:O09110-1, Ser-218, MOD:00046|Thr-222, MOD:00047." [PMID:21183079, PRO:HJD]


organism-sequence



PR:P46734-1

dual specificity mitogen-activated protein kinase kinase 3 isoform 3 (human)

hMAP2K3/iso:3


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 1 that is encoded in the genome of human." [TLR:AMM]


sequence



PR:000021944

dual specificity mitogen-activated protein kinase kinase 3 isoform 2

MAP2K3/iso:2


"A dual specificity mitogen-activated protein kinase kinase 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46734-2 or a 1:1 ortholog thereof." [PMID:7839144, PRO:CNA]


organism-sequence



PR:O09110-2

dual specificity mitogen-activated protein kinase kinase 3 isoform 1 (mouse)

mMAP2K3/iso:1


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:P46734-2

dual specificity mitogen-activated protein kinase kinase 3 isoform 1 (human)

hMAP2K3/iso:1


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036646

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (human)

hMAP2K3/iso:2/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 in human. UniProtKB:P46734-2, Ser-189, MOD:00046|Thr-193, MOD:00047." [PMID:8622669, PRO:CNA]

Yes

modification



PR:000021991

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated form

MAP2K3/iso:2/PhosRes+


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000021946

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1

MAP2K3/iso:2/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated form that has been activated by dual phosphorylation on threonine and tyrosine residues. Example: UniProtKB:P46734-2, Ser-189, MOD:00046|Thr-193, MOD:00047." [PMID:7839144, PMID:8622669, TLR:AMM]


organism-modification



PR:000036646

dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (human)

hMAP2K3/iso:2/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 in human. UniProtKB:P46734-2, Ser-189, MOD:00046|Thr-193, MOD:00047." [PMID:8622669, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036646 hMAP2K3/iso:2/Phos:1
UniProtKB:P46734-2, Ser-189, MOD:00046|Thr-193, MOD:00047
enablesGO:0004708 MAP kinase kinase activity PMID:8622669