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Protein Ontology report - NF-kappa-B inhibitor alpha
PR:000003293 - http://purl.obolibrary.org/obo/PR_000003293
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000003293   
  PRO nameNF-kappa-B inhibitor alpha 
  Synonyms
PRO-Short-label: EXACT:NFKBIA
Gene-based: RELATED:IKBA | MAD3 | NFKBI
Other: EXACT:I-kappa-B-alpha | IkappaBalpha | IkB-alpha | IKBalpha | major histocompatibility complex enhancer-binding protein MAD3
  Definition"An NF-kappa-B inhibitor that is a translation product of the human NFKBIA gene or a 1:1 ortholog thereof." [PMID:19302050, TLR:AMM] 
  CommentRequested by=TLR. 
  PRO Categorygene 
  ParentPR:000003292 NF-kappa-B inhibitor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification2                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000003293
NF-kappa-B inhibitor alpha
NFKBIA
"An NF-kappa-B inhibitor that is a translation product of the human NFKBIA gene or a 1:1 ortholog thereof." [PMID:19302050, TLR:AMM]

organism-gene


PR:P25963
NF-kappa-B inhibitor alpha (human)
hNFKBIA
"An NF-kappa-B inhibitor alpha that is encoded in the genome of human." [TLR:AMM, UniProtKB:P25963]

organism-sequence


PR:000063143
NF-kappa-B inhibitor alpha sequence variant M37K (human)
hNFKBIA/var:M37K
"An NF-kappa-B inhibitor alpha (human) that has a Lys residue at the position equivalent to Met-37 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Met-37, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-5228805]

organism-sequence


PR:000064097
NF-kappa-B inhibitor alpha sequence variant S32I (human)
hNFKBIA/var:S32I
"An NF-kappa-B inhibitor alpha (human) that has an Ile residue at the position equivalent to Ser-32 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Ser-32, CHEBI:30009." [PRO:DNx, Reactome:R-HSA-5228846]

organism-sequence


PR:P25963-1
NF-kappa-B inhibitor alpha isoform 1 (human)
hNFKBIA/iso:1
"An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000028546
NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (human)
hNFKBIA/iso:1/Phos:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in human. UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]

organism-modification


PR:000028548
NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (human)
hNFKBIA/iso:1/PhosUbiq:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]

organism-modification


PR:000045728
NF-kappa-B inhibitor alpha phosphorylated 1 (human)
hNFKBIA/Phos:1
"An NF-kappa-B inhibitor alpha (human) that has been phosphorylated at Tyr-42. UniProtKB:P25963, Tyr-42, MOD:00048." [iPTMnet:P25963, PMID:12429743, PMID:12432072]

organism-modification


PR:000048597
NF-kappa-B inhibitor alpha ubiquitinated form (human)
hNFKBIA/UbiqLys+
"An NF-kappa-B inhibitor alpha (human) that includes at least one ubiquitinated lysine. UniProtKB:P25963, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782960]

organism-modification


PR:000028548
NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (human)
hNFKBIA/iso:1/PhosUbiq:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]

organism-modification


PR:000061305
NF-kappa-B inhibitor alpha phosphorylated 2 (human)
hNFKBIA/Phos:2
"An NF-kappa-B inhibitor alpha (human) that has been phosphorylated on the residues at the positions equivalent to Ser-32 and Ser-36 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Ser-32/Ser-36, MOD:00046." [PRO:DNx, Reactome:R-HSA-177677]

organism-modification


PR:000064833
NF-kappa-B inhibitor alpha sumoylated 1 (human)
hNFKBIA/Sumo:1
"An NF-kappa-B inhibitor alpha (human) that has been sumoylated on the residue at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Lys-21, MOD:01149." [PRO:DNx, Reactome:R-HSA-4656935]

organism-modification


PR:000076169
NF-kappa-B inhibitor alpha methylated 1 (human)
hNFKBIA/Me:1
"An NF-kappa-B inhibitor alpha (human) that has been methylated on the residue at the position equivalent to Cys-215 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Cys-215, MOD:00660." [IEDB_epitope:1001669, IEDB_epitope:1008801, PRO:DNx]

organism-modification


PR:000079620
NF-kappa-B inhibitor alpha cysteinylated 1 (human)
hNFKBIA/Cyst:1
"An NF-kappa-B inhibitor alpha (human) that has been cysteinylated on the residue at the position equivalent to Cys-135 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Cys-135, MOD:00765." [IEDB_epitope:629210, PRO:DNx]

organism-modification


PR:000080276
NF-kappa-B inhibitor alpha methylated 2 (human)
hNFKBIA/Me:2
"An NF-kappa-B inhibitor alpha (human) that has been methylated on the residue at the position equivalent to Cys-186 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Cys-186, MOD:00660." [IEDB_epitope:1019437, IEDB_epitope:1036565, PRO:DNx]

organism-modification


PR:000080277
NF-kappa-B inhibitor alpha cysteinylated 2 (human)
hNFKBIA/Cyst:2
"An NF-kappa-B inhibitor alpha (human) that has been cysteinylated on the residue at the position equivalent to Cys-308 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Cys-308, MOD:00765." [IEDB_epitope:1031108, PRO:DNx]

organism-modification


PR:000084510
NF-kappa-B inhibitor alpha cysteinylated 3 (human)
hNFKBIA/Cyst:3
"An NF-kappa-B inhibitor alpha (human) that has been cysteinylated on the residue at the position equivalent to Cys-167 of the amino acid sequence represented by UniProtKB:P25963. UniProtKB:P25963, Cys-167, MOD:00765." [IEDB_epitope:1004338, PRO:DNx]

organism-gene


PR:Q63746
NF-kappa-B inhibitor alpha (rat)
rNFKBIA
"An NF-kappa-B inhibitor alpha that is encoded in the genome of rat." [OMA:Q63746, PRO:DNx]

organism-gene


PR:Q91974
NF-kappa-B inhibitor alpha (chicken)
chick-NFKBIA
"An NF-kappa-B inhibitor alpha that is encoded in the genome of chicken." [OMA:Q91974, PRO:DNx]

organism-gene


PR:Q9Z1E3
NF-kappa-B inhibitor alpha (mouse)
mNFKBIA
"An NF-kappa-B inhibitor alpha that is encoded in the genome of mouse." [OMA:Q9Z1E3, PRO:DNx]

organism-sequence


PR:Q9Z1E3-1
NF-kappa-B inhibitor alpha isoform 1 (mouse)
mNFKBIA/iso:1
"An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000028550
NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (mouse)
mNFKBIA/iso:1/Phos:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z1E3-1, Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]

organism-modification


PR:000028551
NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (mouse)
mNFKBIA/iso:1/PhosUbiq:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q9Z1E3-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]

sequence


PR:000028543
NF-kappa-B inhibitor alpha isoform 1
NFKBIA/iso:1
"An NF-kappa-B inhibitor alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25963-1 or a 1:1 ortholog thereof." [PMID:10329681, PRO:CNA]

organism-sequence


PR:P25963-1
NF-kappa-B inhibitor alpha isoform 1 (human)
hNFKBIA/iso:1
"An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000028546
NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (human)
hNFKBIA/iso:1/Phos:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in human. UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]

organism-modification


PR:000028548
NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (human)
hNFKBIA/iso:1/PhosUbiq:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]

organism-sequence


PR:Q9Z1E3-1
NF-kappa-B inhibitor alpha isoform 1 (mouse)
mNFKBIA/iso:1
"An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000028550
NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (mouse)
mNFKBIA/iso:1/Phos:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z1E3-1, Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]

organism-modification


PR:000028551
NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (mouse)
mNFKBIA/iso:1/PhosUbiq:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q9Z1E3-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]

modification


PR:000028545
NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1
NFKBIA/iso:1/Phos:1
"An NF-kappa-B inhibitor alpha isoform 1 that has been phosphorylated on the Ser residues in the motif KKx(8-11)SDGxxS. Example: UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PMID:10837071, PRO:CNA]

organism-modification


PR:000028546
NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (human)
hNFKBIA/iso:1/Phos:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in human. UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]

organism-modification


PR:000028550
NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (mouse)
mNFKBIA/iso:1/Phos:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z1E3-1, Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]

modification


PR:000028547
NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1
NFKBIA/iso:1/PhosUbiq:1
"An NF-kappa-B inhibitor alpha isoform 1 that has been phosphorylated on the Ser residues in the motif KKx(8-11)SDGxxS and subsequently ubiquitinated on the Lys residues of the same motif. This modification targets the protein to proteosome degradation. Example: UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PMID:10837071, PRO:CNA]

organism-modification


PR:000028548
NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (human)
hNFKBIA/iso:1/PhosUbiq:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]

organism-modification


PR:000028551
NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (mouse)
mNFKBIA/iso:1/PhosUbiq:1
"An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q9Z1E3-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]