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Protein Ontology report - thyroid hormone receptor alpha

PR:000003428 - http://purl.obolibrary.org/obo/PR_000003428

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000003428

PRO name

thyroid hormone receptor alpha

Synonyms

PRO-Short-label:	EXACT:	THRA
Gene-based:	RELATED:	EAR7 \| ERBA1 \| NR1A1 \| THRA1 \| THRA2
Other:	EXACT:	c-erbA-1 \| c-erbA-alpha \| EAR-7 \| nuclear receptor subfamily 1 group A member 1 \| TR-alpha \| V-erbA-related protein 7

Definition

"A protein that is a translation product of the human THRA gene or a 1:1 ortholog thereof." [MGI:98742, PRO:HJD]

PRO Category

gene

Parent

PR:000000001 protein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	3
Sequence	4	Organism-Sequence	10
Modification	0	Organism-Modification	1

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	IUPHARobj:588

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000003428 thyroid hormone receptor alpha

THRA

organism-gene

PR:P04625 thyroid hormone receptor alpha (chicken)

chick-THRA

organism-gene

PR:P10827 thyroid hormone receptor alpha (human)

hTHRA

organism-sequence

PR:P10827-1 thyroid hormone receptor alpha isoform Alpha-2 (human)

hTHRA/iso:Alpha-2

organism-sequence

PR:P10827-2 thyroid hormone receptor alpha isoform Alpha-1 (human)

hTHRA/iso:Alpha-1

organism-modification

PR:000064694 thyroid hormone receptor alpha isoform Alpha-1 sumoylated 1 (human)

hTHRA/iso:Alpha-1/Sumo:1

organism-sequence

PR:P10827-3 thyroid hormone receptor alpha isoform Alpha-3 (human)

hTHRA/iso:Alpha-3

organism-sequence

PR:P10827-4 thyroid hormone receptor alpha isoform hAlpha-4 (human)

hTHRA/iso:hAlpha-4

organism-gene

PR:P63058 thyroid hormone receptor alpha (mouse)

mTHRA

Yes

organism-sequence

PR:P63058-1 thyroid hormone receptor alpha isoform Alpha-2 (mouse)

mTHRA/iso:Alpha-2

Yes

organism-sequence

PR:P63058-2 thyroid hormone receptor alpha isoform Alpha-1 (mouse)

mTHRA/iso:Alpha-1

Yes

organism-sequence

PR:P63058-3 thyroid hormone receptor alpha isoform Alpha-3 (mouse)

mTHRA/iso:Alpha-3

organism-sequence

PR:P63058-4 thyroid hormone receptor alpha isoform Alpha-deltaE6 (mouse)

mTHRA/iso:Alpha-deltaE6

Yes

sequence

PR:000003429 thyroid hormone receptor alpha isoform Alpha-2

THRA/iso:Alpha-2

organism-sequence

PR:P10827-1 thyroid hormone receptor alpha isoform Alpha-2 (human)

hTHRA/iso:Alpha-2

organism-sequence

PR:P63058-1 thyroid hormone receptor alpha isoform Alpha-2 (mouse)

mTHRA/iso:Alpha-2

Yes

organism-sequence

PR:P63059-1 thyroid hormone receptor alpha isoform Alpha-2 (rat)

rTHRA/iso:Alpha-2

sequence

PR:000022013 thyroid hormone receptor alpha isoform Alpha-1

THRA/iso:Alpha-1

organism-sequence

PR:P10827-2 thyroid hormone receptor alpha isoform Alpha-1 (human)

hTHRA/iso:Alpha-1

organism-modification

PR:000064694 thyroid hormone receptor alpha isoform Alpha-1 sumoylated 1 (human)

hTHRA/iso:Alpha-1/Sumo:1

organism-sequence

PR:P63058-2 thyroid hormone receptor alpha isoform Alpha-1 (mouse)

mTHRA/iso:Alpha-1

Yes

organism-sequence

PR:P63059-2 thyroid hormone receptor alpha isoform Alpha-1 (rat)

rThra/iso:Alpha-1

sequence

PR:000022014 thyroid hormone receptor alpha isoform Alpha-3

THRA/iso:Alpha-3

organism-sequence

PR:P10827-3 thyroid hormone receptor alpha isoform Alpha-3 (human)

hTHRA/iso:Alpha-3

organism-sequence

PR:P63058-3 thyroid hormone receptor alpha isoform Alpha-3 (mouse)

mTHRA/iso:Alpha-3

sequence

PR:000022015 thyroid hormone receptor alpha isoform Alpha-deltaE6

THRA/iso:Alpha-deltaE6

organism-sequence

PR:P63058-4 thyroid hormone receptor alpha isoform Alpha-deltaE6 (mouse)

mTHRA/iso:Alpha-deltaE6

Yes

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Functional Annotation (GO-centric view)

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Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0001502 cartilage condensation	PR:P63058 mTHRA	PMID:9250685
GO:0001503 ossification	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
	PR:P63058 mTHRA	PMID:9927422
GO:0007611 learning or memory	PR:P63058 mTHRA	PMID:17129617
GO:0008016 regulation of heart contraction	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
	PR:P63058 mTHRA	PMID:9430637
GO:0009887 animal organ morphogenesis	PR:P63058 mTHRA	PMID:9927422
GO:0010831 positive regulation of myotube differentiation	PR:P63058-4 mTHRA/iso:Alpha-deltaE6	MGI_ref:3619869; PMID:16322094
GO:0045892 negative regulation of DNA-templated transcription	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:11641275; PMID:15062575
Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0002153 steroid receptor RNA activator RNA binding	PR:P63058-2 mTHRA/iso:Alpha-1	MGI_ref:3050934; PMID:15180993
GO:0003727 single-stranded RNA binding	PR:P63058-2 mTHRA/iso:Alpha-1	MGI_ref:3050934; PMID:15180993
GO:0005515 protein binding	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
	PR:P63058-1 mTHRA/iso:Alpha-2	PMID:15322135
Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005737 cytoplasm	PR:P63058-4 mTHRA/iso:Alpha-deltaE6	MGI_ref:3619869; PMID:16322094