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Protein Ontology report - serine/threonine-protein kinase LMTK1
PR:000003535 - http://purl.obolibrary.org/obo/PR_000003535
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003535   
  PRO nameserine/threonine-protein kinase LMTK1 
  Synonyms
PRO-Short-label: EXACT:AATK
Gene-based: RELATED:AATYK | KIAA0641 | LMR1 | LMTK1
Other: EXACT:apoptosis-associated tyrosine kinase | brain apoptosis-associated tyrosine kinase | CDK5-binding protein | lemur tyrosine kinase 1 | p35-binding protein | p35BP
  Definition"A protein that is a translation product of the human AATK gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 7                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1922
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000003535
serine/threonine-protein kinase LMTK1
AATK
"A protein that is a translation product of the human AATK gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:Q54RV3
serine/threonine-protein kinase pakG (Dictyostelium discoideum)
Dicty-AATK
"A serine/threonine-protein kinase LMTK1 that is encoded in the genome of Dictyostelium discoideum." [PRO:DNx]

organism-gene


PR:Q6ZMQ8
serine/threonine-protein kinase LMTK1 (human)
hAATK
"A serine/threonine-protein kinase LMTK1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q6ZMQ8]

organism-sequence


PR:Q6ZMQ8-1
serine/threonine-protein kinase LMTK1 isoform h1 (human)
hAATK/iso:h1
"A serine/threonine-protein kinase LMTK1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZMQ8-1." [PRO:DNx, UniProtKB:Q6ZMQ8]

organism-sequence


PR:Q6ZMQ8-2
serine/threonine-protein kinase LMTK1 isoform h2 (human)
hAATK/iso:h2
"A serine/threonine-protein kinase LMTK1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZMQ8-2." [PRO:DNx, UniProtKB:Q6ZMQ8]

organism-sequence


PR:Q6ZMQ8-3
serine/threonine-protein kinase LMTK1 isoform h3 (human)
hAATK/iso:h3
"A serine/threonine-protein kinase LMTK1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZMQ8-3." [PRO:DNx, UniProtKB:Q6ZMQ8]

organism-gene


PR:Q80YE4
serine/threonine-protein kinase LMTK1 (mouse)
mAATK
"A serine/threonine-protein kinase LMTK1 that is encoded in the genome of mouse." [OMA:Q80YE4, PRO:DNx]

organism-sequence


PR:Q80YE4-1
serine/threonine-protein kinase LMTK1 isoform 1 (mouse)
mAATK/iso:1
"A serine/threonine-protein kinase LMTK1 isoform 1 that is encoded in the genome of mouse." [PMID:11314039, PRO:HJD]
Yes
organism-sequence


PR:Q80YE4-2
serine/threonine-protein kinase LMTK1 isoform 2 (mouse)
mAATK/iso:2
"A serine/threonine-protein kinase LMTK1 isoform 2 that is encoded in the genome of mouse." [PMID:9444961, PRO:HJD]
Yes
organism-modification


PR:000035696
serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1 (mouse)
mAATK/iso:2/Palm:1
"A serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1 in mouse. UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115." [PMID:18691334, PRO:KRC]
Yes
organism-modification


PR:000035698
serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated and phosphorylated 1 (mouse)
mAATK/iso:2/PalmPhos:1
"A serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated and phosphorylated 1 in mouse. UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115|Tyr-25/Tyr-46, MOD:00048." [PMID:18691334, PRO:KRC]

organism-modification


PR:000035700
serine/threonine-protein kinase LMTK1 isoform 2 phosphorylated 1 (mouse)
mAATK/iso:2/Phos:1
"A serine/threonine-protein kinase LMTK1 isoform 2 phosphorylated 1 in mouse. UniProtKB:Q80YE4-2, Ser-34, MOD:00046." [PMID:22573681, PRO:KRC]
Yes
organism-sequence


PR:Q80YE4-3
serine/threonine-protein kinase LMTK1 isoform 3 (mouse)
mAATK/iso:3
"A serine/threonine-protein kinase LMTK1 isoform 3 that is encoded in the genome of mouse." [PMID:17651901, PRO:HJD]
Yes
organism-sequence


PR:Q80YE4-4
serine/threonine-protein kinase LMTK1 isoform m4 (mouse)
mAATK/iso:m4
"A serine/threonine-protein kinase LMTK1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80YE4-4." [PRO:DNx, UniProtKB:Q80YE4]

sequence


PR:000035374
serine/threonine-protein kinase LMTK1 isoform 1
AATK/iso:1
"A serine/threonine-protein kinase LMTK1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80YE4-1 or a 1:1 ortholog thereof." [PMID:11314039, PRO:HJD]

organism-sequence


PR:Q80YE4-1
serine/threonine-protein kinase LMTK1 isoform 1 (mouse)
mAATK/iso:1
"A serine/threonine-protein kinase LMTK1 isoform 1 that is encoded in the genome of mouse." [PMID:11314039, PRO:HJD]
Yes
sequence


PR:000035376
serine/threonine-protein kinase LMTK1 isoform 2
AATK/iso:2
"A serine/threonine-protein kinase LMTK1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80YE4-2 or a 1:1 ortholog thereof." [PRO:HJD]

organism-sequence


PR:Q80YE4-2
serine/threonine-protein kinase LMTK1 isoform 2 (mouse)
mAATK/iso:2
"A serine/threonine-protein kinase LMTK1 isoform 2 that is encoded in the genome of mouse." [PMID:9444961, PRO:HJD]
Yes
organism-modification


PR:000035696
serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1 (mouse)
mAATK/iso:2/Palm:1
"A serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1 in mouse. UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115." [PMID:18691334, PRO:KRC]
Yes
organism-modification


PR:000035698
serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated and phosphorylated 1 (mouse)
mAATK/iso:2/PalmPhos:1
"A serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated and phosphorylated 1 in mouse. UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115|Tyr-25/Tyr-46, MOD:00048." [PMID:18691334, PRO:KRC]

organism-modification


PR:000035700
serine/threonine-protein kinase LMTK1 isoform 2 phosphorylated 1 (mouse)
mAATK/iso:2/Phos:1
"A serine/threonine-protein kinase LMTK1 isoform 2 phosphorylated 1 in mouse. UniProtKB:Q80YE4-2, Ser-34, MOD:00046." [PMID:22573681, PRO:KRC]
Yes
modification


PR:000035695
serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1
AATK/iso:2/Palm:1
"A serine/threonine-protein kinase LMTK1 isoform 2 that has been palmitoylated on the Cys residues in the motif CLCCKK located at the N-terminal region. Example: UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115." [PMID:18691334, PRO:KRC]

organism-modification


PR:000035696
serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1 (mouse)
mAATK/iso:2/Palm:1
"A serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1 in mouse. UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115." [PMID:18691334, PRO:KRC]
Yes
modification


PR:000035697
serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated and phosphorylated 1
AATK/iso:2/PalmPhos:1
"A serine/threonine-protein kinase LMTK1 isoform 2 that has been palmitoylated on the Cys residues in the motif CLCCKK located at the N-terminal region, and phosphorylated on two Tyr in Src family tyrosine kinases (SFKs) sites. Palmitoylation is necessary for the phosphorylation to occur. Example: UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115|Tyr-25/Tyr-46, MOD:00048." [PMID:18691334, PRO:CNA]

organism-modification


PR:000035698
serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated and phosphorylated 1 (mouse)
mAATK/iso:2/PalmPhos:1
"A serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated and phosphorylated 1 in mouse. UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115|Tyr-25/Tyr-46, MOD:00048." [PMID:18691334, PRO:KRC]

modification


PR:000035699
serine/threonine-protein kinase LMTK1 isoform 2 phosphorylated 1
AATK/iso:2/Phos:1
"A serine/threonine-protein kinase LMTK1 isoform 2 that been phosphorylated at the Ser residue in the sequence QGSPA within the N-terminal region. Example: UniProtKB:Q80YE4-2, Ser-34, MOD:00046." [PMID:20422042, PMID:22573681, PRO:CNA]

organism-modification


PR:000035700
serine/threonine-protein kinase LMTK1 isoform 2 phosphorylated 1 (mouse)
mAATK/iso:2/Phos:1
"A serine/threonine-protein kinase LMTK1 isoform 2 phosphorylated 1 in mouse. UniProtKB:Q80YE4-2, Ser-34, MOD:00046." [PMID:22573681, PRO:KRC]
Yes
sequence


PR:000035378
serine/threonine-protein kinase LMTK1 isoform 3
AATK/iso:3
"A serine/threonine-protein kinase LMTK1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80YE4-3 or a 1:1 ortholog thereof." [PMID:17651901, PRO:HJD]

organism-sequence


PR:Q80YE4-3
serine/threonine-protein kinase LMTK1 isoform 3 (mouse)
mAATK/iso:3
"A serine/threonine-protein kinase LMTK1 isoform 3 that is encoded in the genome of mouse." [PMID:17651901, PRO:HJD]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035696 mAATK/iso:2/Palm:1
UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115		 enablesGO:0005515 protein binding with PR:P12931 hSRC MGI_ref:3820458; PMID:18691334
located_inGO:0055037 recycling endosome MGI_ref:3820458; PMID:18691334
PR:000035700 mAATK/iso:2/Phos:1
UniProtKB:Q80YE4-2, Ser-34, MOD:00046		 acts_upstream_of_or_withinGO:0030517 negative regulation of axon extension MGI_ref:5426470; PMID:22573681
GO:0030517 negative regulation of axon extension MGI_ref:5426470; PMID:22573681
located_inGO:0044295 axonal growth cone MGI_ref:5426470; PMID:22573681
GO:0048471 perinuclear region of cytoplasm MGI_ref:5426470; PMID:22573681
GO:0055037 recycling endosome MGI_ref:5426470; PMID:22573681
PR:Q80YE4-1 mAATK/iso:1 acts_upstream_of_or_withinGO:0046777 protein autophosphorylation MGI_ref:3766666; PMID:17651901
PR:Q80YE4-2 mAATK/iso:2 acts_upstream_of_or_withinGO:0046777 protein autophosphorylation MGI_ref:3766666; PMID:17651901
enablesGO:0005515 protein binding with PR:P12931 hSRC MGI_ref:3820458; PMID:18691334
PR:Q80YE4-3 mAATK/iso:3 acts_upstream_of_or_withinGO:0046777 protein autophosphorylation MGI_ref:3766666; PMID:17651901
located_inGO:0005783 endoplasmic reticulum MGI_ref:3820458; PMID:18691334