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Protein Ontology report - beta-1,4-galactosyltransferase 1
PR:000004605 - http://purl.obolibrary.org/obo/PR_000004605
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000004605   
  PRO namebeta-1,4-galactosyltransferase 1 
  Synonyms
PRO-Short-label: EXACT:B4GALT1
Gene-based: RELATED:Ggtb | GGTB2
Other: EXACT:b4Gal-T1 | beta-1,4-GalTase 1 | beta4Gal-T1 | lactose synthase A protein | UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 | UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
  Definition"A protein that is a translation product of the human B4GALT1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 7                                        
         Modification1                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000004605

beta-1,4-galactosyltransferase 1

B4GALT1


"A protein that is a translation product of the human B4GALT1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P15291

beta-1,4-galactosyltransferase 1 (human)

hB4GALT1


"A beta-1,4-galactosyltransferase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P15291]


organism-sequence



PR:P15291-1

beta-1,4-galactosyltransferase 1 isoform 1 (human)

hB4GALT1/iso:1


"A beta-1,4-galactosyltransferase 1 isoform 1 that is encoded in the genome of human." [PMID:14702039, PMID:3144273, PRO:CNA, UniProtKB:P15291]


organism-sequence



PR:P15291-2

beta-1,4-galactosyltransferase 1 isoform 2 (human)

hB4GALT1/iso:2


"A beta-1,4-galactosyltransferase 1 isoform 2 that is encoded in the genome of human." [PMID:14702039, PRO:CNA, UniProtKB:P15291]


organism-modification



PR:000055487

beta-1,4-galactosyltransferase 1 O-glycosylated 1 (human)

hB4GALT1/OGlyco:1


"A beta-1,4-galactosyltransferase 1 (human) that has been O-glycosylated at the residue equivalent to Ser-66 of the amino acid sequence represented by UniProtKB:P15291-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P15291-1, Ser-66, MOD:00002~GNO:G43417UB." [GlyGen:P15291-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000055488

beta-1,4-galactosyltransferase 1 O-glycosylated 2 (human)

hB4GALT1/OGlyco:2


"A beta-1,4-galactosyltransferase 1 (human) that has been O-glycosylated at the residue equivalent to Thr-115 of the amino acid sequence represented by UniProtKB:P15291-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P15291-1, Thr-115, MOD:00005~GNO:G43417UB." [GlyGen:P15291-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000055489

beta-1,4-galactosyltransferase 1 O-glycosylated 3 (human)

hB4GALT1/OGlyco:3


"A beta-1,4-galactosyltransferase 1 (human) that has been O-glycosylated at the residue equivalent to Thr-58 of the amino acid sequence represented by UniProtKB:P15291-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P15291-1, Thr-58, MOD:00005~GNO:G43417UB." [GlyGen:P15291-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000055490

beta-1,4-galactosyltransferase 1 O-glycosylated 4 (human)

hB4GALT1/OGlyco:4


"A beta-1,4-galactosyltransferase 1 (human) that has been O-glycosylated at the residue equivalent to Thr-79 of the amino acid sequence represented by UniProtKB:P15291-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P15291-1, Thr-79, MOD:00005~GNO:G43417UB." [GlyGen:P15291-1, PMID:30459171, PRO:DNx]


organism-gene



PR:P15535

beta-1,4-galactosyltransferase 1 (mouse)

mB4GALT1


"A beta-1,4-galactosyltransferase 1 that is encoded in the genome of mouse." [OMA:P15535, PRO:DNx]


organism-sequence



PR:P15535-1

beta-1,4-galactosyltransferase 1 isoform 1 (mouse)

mB4GALT1/iso:1


"A beta-1,4-galactosyltransferase 1 isoform 1 that is encoded in the genome of mouse." [PMID:3134348, PRO:HJD]

Yes

organism-sequence



PR:P15535-2

beta-1,4-galactosyltransferase 1 isoform 2 (mouse)

mB4GALT1/iso:2


"A beta-1,4-galactosyltransferase 1 isoform 2 that is encoded in the genome of mouse." [PMID:689054, PRO:HJD]


organism-gene



PR:Q9GUM2

beta-1,4-N-acetylgalactosaminyltransferase bre-4 (worm)

B4GALT1 (worm)


"A beta-1,4-galactosyltransferase 1 that is encoded in the genome of worm." [OMA:Q9GUM2, PRO:DNx]


organism-sequence



PR:Q9GUM2-1

beta-1,4-N-acetylgalactosaminyltransferase bre-4 isoform a (worm)

B4GALT1/iso:a (worm)


"A beta-1,4-N-acetylgalactosaminyltransferase bre-4 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9GUM2-1." [PRO:DNx, UniProtKB:Q9GUM2]


organism-sequence



PR:Q9GUM2-2

beta-1,4-N-acetylgalactosaminyltransferase bre-4 isoform b (worm)

B4GALT1/iso:b (worm)


"A beta-1,4-N-acetylgalactosaminyltransferase bre-4 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9GUM2-2." [PRO:DNx, UniProtKB:Q9GUM2]


sequence



PR:000037348

beta-1,4-galactosyltransferase 1 isoform 1

B4GALT1/iso:1


"A beta-1,4-galactosyltransferase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15535-1 or a 1:1 ortholog thereof." [PMID:3134348, PRO:HJD]


organism-sequence



PR:G3V722

beta-1,4-galactosyltransferase 1 isoform 1 (rat)

rB4GALT1/iso:1


"A beta-1,4-galactosyltransferase 1 isoform 1 that is encoded in the genome of rat." [PMID:22706684, PRO:CNA]


organism-sequence



PR:P15291-1

beta-1,4-galactosyltransferase 1 isoform 1 (human)

hB4GALT1/iso:1


"A beta-1,4-galactosyltransferase 1 isoform 1 that is encoded in the genome of human." [PMID:14702039, PMID:3144273, PRO:CNA, UniProtKB:P15291]


organism-sequence



PR:P15535-1

beta-1,4-galactosyltransferase 1 isoform 1 (mouse)

mB4GALT1/iso:1


"A beta-1,4-galactosyltransferase 1 isoform 1 that is encoded in the genome of mouse." [PMID:3134348, PRO:HJD]

Yes

sequence



PR:000037349

beta-1,4-galactosyltransferase 1 isoform 2

B4GALT1/iso:2


"A beta-1,4-galactosyltransferase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15535-2 or a 1:1 ortholog thereof." [PMID:689054, PRO:HJD]


organism-sequence



PR:P15291-2

beta-1,4-galactosyltransferase 1 isoform 2 (human)

hB4GALT1/iso:2


"A beta-1,4-galactosyltransferase 1 isoform 2 that is encoded in the genome of human." [PMID:14702039, PRO:CNA, UniProtKB:P15291]


organism-sequence



PR:P15535-2

beta-1,4-galactosyltransferase 1 isoform 2 (mouse)

mB4GALT1/iso:2


"A beta-1,4-galactosyltransferase 1 isoform 2 that is encoded in the genome of mouse." [PMID:689054, PRO:HJD]


modification



PR:000019111

beta-1,4-galactosyltransferase 1 proteolytic cleavage product

B4GALT1/ClvPrd


"A beta-1,4-galactosyltransferase 1 that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P15535-1 mB4GALT1/iso:1 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation MGI_ref:75839; PMID:7641815
GO:0030198 extracellular matrix organization MGI_ref:84206; PMID:8787759
GO:0030879 mammary gland development MGI_ref:2178150; PMID:11900463
GO:0042127 regulation of cell population proliferation MGI_ref:75839; PMID:7641815
GO:0048754 branching morphogenesis of an epithelial tube MGI_ref:3052392; PMID:15282149
GO:0048754 branching morphogenesis of an epithelial tube MGI_ref:3052392; PMID:15282149
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution MGI_ref:3052392; PMID:15282149
enablesGO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity MGI_ref:84206; PMID:8787759
GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity MGI_ref:84206; PMID:8787759
GO:0008092 cytoskeletal protein binding MGI_ref:75839; PMID:7641815
GO:0008092 cytoskeletal protein binding MGI_ref:75839; PMID:7641815
GO:0008378 galactosyltransferase activity MGI_ref:68417; PMID:8089187
GO:0008378 galactosyltransferase activity MGI_ref:68417; PMID:8089187
located_inGO:0009986 cell surface MGI_ref:84206; PMID:8787759
GO:0009986 cell surface MGI_ref:84206; PMID:8787759
GO:0009986 cell surface MGI_ref:84206; PMID:8787759
GO:0009986 cell surface MGI_ref:84206; PMID:8787759