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Protein Ontology report - beta-secretase 1
PR:000004615 - http://purl.obolibrary.org/obo/PR_000004615
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000004615   
  PRO namebeta-secretase 1 
  Synonyms
PRO-Short-label: EXACT:BACE1
Gene-based: RELATED:BACE | KIAA1149
Other: EXACT:Asp 2 | ASP2 | aspartyl protease 2 | beta-site amyloid precursor protein cleaving enzyme 1 | beta-site APP cleaving enzyme 1 | memapsin-2 | membrane-associated aspartic protease 2
  Definition"A protein that is a translation product of the human BACE1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  CommentRequested by=Alzforum. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 8                                        
         Modification1                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2330
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000004615
beta-secretase 1
BACE1
"A protein that is a translation product of the human BACE1 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:P56817
beta-secretase 1 (human)
hBACE1
"A beta-secretase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P56817]

organism-sequence


PR:P56817-1
beta-secretase 1 isoform A (human)
hBACE1/iso:A
"A beta-secretase 1 isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-sequence


PR:P56817-2
beta-secretase 1 isoform B (human)
hBACE1/iso:B
"A beta-secretase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-2." [PRO:DNx, UniProtKB:P56817]

organism-sequence


PR:P56817-3
beta-secretase 1 isoform C (human)
hBACE1/iso:C
"A beta-secretase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-3." [PRO:DNx, UniProtKB:P56817]

organism-sequence


PR:P56817-4
beta-secretase 1 isoform D (human)
hBACE1/iso:D
"A beta-secretase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-4." [PRO:DNx, UniProtKB:P56817]

organism-sequence


PR:P56817-5
beta-secretase 1 isoform h5 (human)
hBACE1/iso:h5
"A beta-secretase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-5." [PRO:DNx, UniProtKB:P56817]

organism-sequence


PR:P56817-6
beta-secretase 1 isoform h6 (human)
hBACE1/iso:h6
"A beta-secretase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-6." [PRO:DNx, UniProtKB:P56817]

organism-modification


PR:000045841
beta-secretase 1 phosphorylated 1 (human)
hBACE1/Phos:1
"A beta-secretase 1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-252 of the amino acid sequence represented by UniProtKB:P56817-1. Example: UniProtKB:P56817-1, Thr-252, MOD:00047." [iPTMnet:P56817, PMID:26317805]

organism-modification


PR:000046453
beta-secretase 1, signal peptide removed form (human)
hBACE1/SigPep-
"A beta-secretase 1 (human) that has had the signal peptide removed. UniProtKB:P56817, 22-501." [PRO:DNx, Reactome:R-HSA-6783326]

organism-modification


PR:000046454
beta-secretase 1, signal peptide removed acetylated 1 (human)
hBACE1/SigPep-/Ac:1
"A beta-secretase 1 (human) that has had the signal peptide removed and has been post-translationally modified to include N6-acetyllysine at positions 126, 275, 279, 285, 299, 300 and 307 of the amino acid sequence represented by UniProtKB:P56817. UniProtKB:P56817, 22-501, Lys-126/Lys-275/Lys-279/Lys-285/Lys-299/Lys-300/Lys-307, MOD:00064." [PRO:DNx, Reactome:R-HSA-5693006, Reactome:R-HSA-5693095]

organism-modification


PR:000077144
beta-secretase 1, mature form (human)
hBACE1/mature
"A beta-secretase 1 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P56817-1, 46-501." [PRO:DNx, Reactome:R-HSA-5692942, Reactome:R-HSA-5693105]

organism-modification


PR:000077147
beta-secretase 1, mature acetylated 1 (human)
hBACE1/mature/Ac:1
"A beta-secretase 1 (human) that has had the signal peptide and propeptide removed, and that has been acetylated on the residues at the positions equivalent to Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300, and Lys-307 of the amino acid sequence represented by UniProtKB:P56817-1. Example: UniProtKB:P56817-1, 46-501, Lys-126/Lys-275/Lys-279/Lys-285/Lys-299/Lys-300/Lys-307, MOD:00064." [PRO:DNx, Reactome:R-HSA-5693106]

organism-modification


PR:000077144
beta-secretase 1, mature form (human)
hBACE1/mature
"A beta-secretase 1 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P56817-1, 46-501." [PRO:DNx, Reactome:R-HSA-5692942, Reactome:R-HSA-5693105]

organism-modification


PR:000077147
beta-secretase 1, mature acetylated 1 (human)
hBACE1/mature/Ac:1
"A beta-secretase 1 (human) that has had the signal peptide and propeptide removed, and that has been acetylated on the residues at the positions equivalent to Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300, and Lys-307 of the amino acid sequence represented by UniProtKB:P56817-1. Example: UniProtKB:P56817-1, 46-501, Lys-126/Lys-275/Lys-279/Lys-285/Lys-299/Lys-300/Lys-307, MOD:00064." [PRO:DNx, Reactome:R-HSA-5693106]

organism-modification


PR:000081150
beta-secretase 1 cysteinylated 1 (human)
hBACE1/Cyst:1
"A beta-secretase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-278 of the amino acid sequence represented by UniProtKB:P56817-1. Example: UniProtKB:P56817-1, Cys-278, MOD:00765." [IEDB_epitope:1564498, PRO:DNx]

organism-gene


PR:P56818
beta-secretase 1 (mouse)
mBACE1
"A beta-secretase 1 that is encoded in the genome of mouse." [OMA:P56818, PRO:DNx]

organism-sequence


PR:P56818-1
beta-secretase 1 isoform 1 (mouse)
mBACE1/iso:1
"A beta-secretase 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

organism-modification


PR:000044619
beta-secretase 1 isoform 1 N-glycosylated 1 (mouse)
mBACE1/iso:1/NGlyco:1
"A beta-secretase 1 isoform 1 (mouse) that has been glycosylated at the position equivalent to Asn-153 of the amino acid sequence represented by UniProtKB:P56818-1. UniProtKB:P56818-1, Asn-153, MOD:00160." [PMID:26467158, PRO:LN]

organism-modification


PR:000044620
beta-secretase 1 isoform 1 N-glycosylated 3 (mouse)
mBACE1/iso:1/NGlyco:3
"A beta-secretase 1 isoform 1 (mouse) that has been glycosylated at the position equivalent to Asn-172 of the amino acid sequence represented by UniProtKB:P56818-1. UniProtKB:P56818-1, Asn-172, MOD:00160." [PMID:26467158, PRO:LN]

organism-modification


PR:000044621
beta-secretase 1 isoform 1 N-glycosylated 2 (mouse)
mBACE1/iso:1/NGlyco:2
"A beta-secretase 1 isoform 1 (mouse) that has been glycosylated at the position equivalent to Asn-223 of the amino acid sequence represented by UniProtKB:P56818-1. UniProtKB:P56818-1, Asn-223, MOD:00160." [PMID:26467158, PRO:LN]

organism-modification


PR:000044622
beta-secretase 1 isoform 1 N-glycosylated 5 (mouse)
mBACE1/iso:1/NGlyco:5
"A beta-secretase 1 isoform 1 (mouse) that has been glycosylated at positions equivalent to Asn-153 and Asn-223 of the amino acid sequence represented by UniProtKB:P56818-1. UniProtKB:P56818-1, Asn-153/Asn-223, MOD:00160." [PMID:26467158, PRO:LN]

organism-modification


PR:000044623
beta-secretase 1 isoform 1 N-glycosylated 4 (mouse)
mBACE1/iso:1/NGlyco:4
"A beta-secretase 1 isoform 1 (mouse) that has been glycosylated at the position equivalent to Asn-354 of the amino acid sequence represented by UniProtKB:P56818-1. UniProtKB:P56818-1, Asn-354, MOD:00160." [PMID:26467158, PRO:LN]

organism-gene


PR:P56819
beta-secretase 1 (rat)
rBACE1
"A beta-secretase 1 that is encoded in the genome of rat." [OMA:P56819, PRO:DNx]

organism-sequence


PR:P56819-1
beta-secretase 1 isoform 1 (rat)
rBACE1/iso:1
"A beta-secretase 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]

sequence


PR:000039837
beta-secretase 1 isoform 1
BACE1/iso:1
"A beta-secretase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-1 or a 1:1 ortholog thereof." [PRO:DNx]

organism-sequence


PR:P56817-1
beta-secretase 1 isoform A (human)
hBACE1/iso:A
"A beta-secretase 1 isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-sequence


PR:P56818-1
beta-secretase 1 isoform 1 (mouse)
mBACE1/iso:1
"A beta-secretase 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

organism-modification


PR:000044619
beta-secretase 1 isoform 1 N-glycosylated 1 (mouse)
mBACE1/iso:1/NGlyco:1
"A beta-secretase 1 isoform 1 (mouse) that has been glycosylated at the position equivalent to Asn-153 of the amino acid sequence represented by UniProtKB:P56818-1. UniProtKB:P56818-1, Asn-153, MOD:00160." [PMID:26467158, PRO:LN]

organism-modification


PR:000044620
beta-secretase 1 isoform 1 N-glycosylated 3 (mouse)
mBACE1/iso:1/NGlyco:3
"A beta-secretase 1 isoform 1 (mouse) that has been glycosylated at the position equivalent to Asn-172 of the amino acid sequence represented by UniProtKB:P56818-1. UniProtKB:P56818-1, Asn-172, MOD:00160." [PMID:26467158, PRO:LN]

organism-modification


PR:000044621
beta-secretase 1 isoform 1 N-glycosylated 2 (mouse)
mBACE1/iso:1/NGlyco:2
"A beta-secretase 1 isoform 1 (mouse) that has been glycosylated at the position equivalent to Asn-223 of the amino acid sequence represented by UniProtKB:P56818-1. UniProtKB:P56818-1, Asn-223, MOD:00160." [PMID:26467158, PRO:LN]

organism-modification


PR:000044622
beta-secretase 1 isoform 1 N-glycosylated 5 (mouse)
mBACE1/iso:1/NGlyco:5
"A beta-secretase 1 isoform 1 (mouse) that has been glycosylated at positions equivalent to Asn-153 and Asn-223 of the amino acid sequence represented by UniProtKB:P56818-1. UniProtKB:P56818-1, Asn-153/Asn-223, MOD:00160." [PMID:26467158, PRO:LN]

organism-modification


PR:000044623
beta-secretase 1 isoform 1 N-glycosylated 4 (mouse)
mBACE1/iso:1/NGlyco:4
"A beta-secretase 1 isoform 1 (mouse) that has been glycosylated at the position equivalent to Asn-354 of the amino acid sequence represented by UniProtKB:P56818-1. UniProtKB:P56818-1, Asn-354, MOD:00160." [PMID:26467158, PRO:LN]

organism-sequence


PR:P56819-1
beta-secretase 1 isoform 1 (rat)
rBACE1/iso:1
"A beta-secretase 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]

modification


PR:000019112
beta-secretase 1 proteolytic cleavage product
BACE1/ClvPrd
"A beta-secretase 1 that has been processed by proteolytic cleavage." [PRO:DNx]