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Protein Ontology report - mitotic checkpoint protein BUB3
PR:000004856 - http://purl.obolibrary.org/obo/PR_000004856
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000004856   
  PRO namemitotic checkpoint protein BUB3 
  Synonyms
PRO-Short-label: EXACT:BUB3
Other: EXACT:WD repeat type I transmembrane protein A72.5
  Definition"A protein that is a translation product of the human BUB3 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 7                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification2                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000004856
mitotic checkpoint protein BUB3
BUB3
"A protein that is a translation product of the human BUB3 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:O42860
spindle assembly checkpoint protein bub3 (Schizosaccharomyces pombe 972h-)
Spom972h-BUB3
"A mitotic checkpoint protein BUB3 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O42860, PRO:KER]

Yes
organism-gene


PR:O43684
mitotic checkpoint protein BUB3 (human)
hBUB3
"A mitotic checkpoint protein BUB3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43684]
Yes
Yes
organism-sequence


PR:O43684-1
mitotic checkpoint protein BUB3 isoform h1 (human)
hBUB3/iso:h1
"A mitotic checkpoint protein BUB3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43684-1." [PRO:DNx, UniProtKB:O43684]

organism-sequence


PR:O43684-2
mitotic checkpoint protein BUB3 isoform 2 (human)
hBUB3/iso:2
"A mitotic checkpoint protein BUB3 isoform 2 that is encoded in the genome of human." [PRO:DNx]

organism-modification


PR:000035437
mitotic checkpoint protein BUB3 phosphorylated 1 (human)
hBUB3/Phos:1
"A mitotic checkpoint protein BUB3 phosphorylated 1 in human. Phosphorylated on the Ser residue within the motif D[YG]ISx[IV]K. UniProtKB:O43684, Ser-18, MOD:00046." [PMID:20057499, PRO:DAN, PRO:KER]
Yes
organism-modification


PR:000035454
mitotic checkpoint protein BUB3 unphosphorylated form (human)
hBUB3/PhosRes-
"A mitotic checkpoint protein BUB3 unphosphorylated form in human." [PRO:KER]

organism-modification


PR:000045593
mitotic checkpoint protein BUB3 phosphorylated 2 (human)
hBUB3/Phos:2
"A mitotic checkpoint protein BUB3 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-207 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Tyr-207, MOD:00048." [iPTMnet:O43684, PMID:24316223]

organism-modification


PR:000071531
mitotic checkpoint protein BUB3 methylated 1 (human)
hBUB3/Me:1
"A mitotic checkpoint protein BUB3 (human) that has been methylated on the residue at the position equivalent to Cys-101 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-101, MOD:00660." [IEDB_epitope:1054024, PRO:DNx]

organism-modification


PR:000071980
mitotic checkpoint protein BUB3 cysteinylated 1 (human)
hBUB3/Cyst:1
"A mitotic checkpoint protein BUB3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-184 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-184, MOD:00765." [IEDB_epitope:637078, PRO:DNx]

organism-modification


PR:000072028
mitotic checkpoint protein BUB3 cysteinylated 2 (human)
hBUB3/Cyst:2
"A mitotic checkpoint protein BUB3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-62 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-62, MOD:00765." [IEDB_epitope:924870, PRO:DNx]

organism-modification


PR:000072190
mitotic checkpoint protein BUB3 methylated 2 (human)
hBUB3/Me:2
"A mitotic checkpoint protein BUB3 (human) that has been methylated on the residue at the position equivalent to Cys-105 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-105, MOD:00660." [IEDB_epitope:1057223, IEDB_epitope:1057225, PRO:DNx]

organism-modification


PR:000072404
mitotic checkpoint protein BUB3 acetylated 1 (human)
hBUB3/Ac:1
"A mitotic checkpoint protein BUB3 (human) that has been acetylated on the residue at the position equivalent to Lys-8 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Lys-8, MOD:00723." [IEDB_epitope:1832182, PRO:DNx]

organism-modification


PR:000073832
mitotic checkpoint protein BUB3 methylated 3 (human)
hBUB3/Me:3
"A mitotic checkpoint protein BUB3 (human) that has been methylated on the residue at the position equivalent to Phe-284 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Phe-284, MOD:00717." [IEDB_epitope:1324242, PRO:DNx]

organism-modification


PR:000074693
mitotic checkpoint protein BUB3 cysteinylated 3 (human)
hBUB3/Cyst:3
"A mitotic checkpoint protein BUB3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-105 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-105, MOD:00765." [IEDB_epitope:1057224, IEDB_epitope:1060796, PRO:DNx]

organism-modification


PR:000079964
mitotic checkpoint protein BUB3 deaminated 1 (human)
hBUB3/Deam:1
"A mitotic checkpoint protein BUB3 (human) that has been deaminated on the residue at the position equivalent to Gln-28 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Gln-28, MOD:00685." [IEDB_epitope:2140672, PRO:DNx]

organism-modification


PR:000083767
mitotic checkpoint protein BUB3 hydroxylated 1 (human)
hBUB3/Hy:1
"A mitotic checkpoint protein BUB3 (human) that has been hydroxylated on the residue at the position equivalent to Trp-71 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Trp-71, MOD:01622." [IEDB_epitope:1317184, PRO:DNx]

organism-modification


PR:000083783
mitotic checkpoint protein BUB3 methylated 4 (human)
hBUB3/Me:4
"A mitotic checkpoint protein BUB3 (human) that has been methylated on the residue at the position equivalent to Cys-129 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-129, MOD:00660." [IEDB_epitope:1025305, PRO:DNx]

organism-modification


PR:000083859
mitotic checkpoint protein BUB3 deaminated 2 (human)
hBUB3/Deam:2
"A mitotic checkpoint protein BUB3 (human) that has been deaminated on the residue at the position equivalent to Gln-118 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Gln-118, MOD:00685." [IEDB_epitope:760621, PRO:DNx]

organism-modification


PR:000084196
mitotic checkpoint protein BUB3 deaminated 3 (human)
hBUB3/Deam:3
"A mitotic checkpoint protein BUB3 (human) that has been deaminated on the residue at the position equivalent to Asn-247 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Asn-247, MOD:00684." [IEDB_epitope:764763, PRO:DNx]

organism-modification


PR:000085371
mitotic checkpoint protein BUB3 cysteinylated 4 (human)
hBUB3/Cyst:4
"A mitotic checkpoint protein BUB3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-129 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Cys-129, MOD:00765." [IEDB_epitope:927829, PRO:DNx]

organism-gene


PR:P26449
spindle assembly checkpoint protein BUB3 (yeast)
yBUB3
"A mitotic checkpoint protein BUB3 that is encoded in the genome of yeast." [OMA:P26449, PRO:KER]
Yes
Yes
organism-modification


PR:000035438
cell cycle arrest protein BUB3 phosphorylated 1 (yeast)
yBUB3/Phos:1
"A mitotic checkpoint protein BUB3 phosphorylated 1 in yeast. UniProtKB:P26449, Ser-15, MOD:00046." [PMID:7969164, PRO:DAN, PRO:KER]

organism-gene


PR:Q54DM1
mitotic checkpoint protein bub3 (Dictyostelium discoideum)
Dicty-BUB3
"A mitotic checkpoint protein BUB3 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54DM1, PRO:DNx]

organism-gene


PR:Q9WVA3
mitotic checkpoint protein BUB3 (mouse)
mBUB3
"A mitotic checkpoint protein BUB3 that is encoded in the genome of mouse." [OMA:Q9WVA3, PRO:DNx]

organism-sequence


PR:Q9WVA3-1
mitotic checkpoint protein BUB3 isoform 1 (mouse)
mBUB3/iso:1
"A mitotic checkpoint protein BUB3 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]

organism-gene


PR:Q9XWH0
mitotic checkpoint protein bub-3 (worm)
BUB3 (worm)
"A mitotic checkpoint protein BUB3 that is encoded in the genome of worm." [OMA:Q9XWH0, PRO:DNx]

organism-gene


PR:Q9YGY3
mitotic checkpoint protein BUB3 (frog)
frog-BUB3
"A mitotic checkpoint protein BUB3 that is encoded in the genome of frog." [PRO:KER]

Yes
organism-sequence


PR:Q9YGY3-1
mitotic checkpoint protein BUB3 isoform 1 (frog)
frog-BUB3/iso:1
"A mitotic checkpoint protein BUB3 (frog) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9YGY3-1." [PRO:DNx, UniProtKB:Q9YGY3]

organism-sequence


PR:Q9YGY3-2
mitotic checkpoint protein BUB3 isoform 2 (frog)
frog-BUB3/iso:2
"A mitotic checkpoint protein BUB3 (frog) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9YGY3-2." [PRO:DNx, UniProtKB:Q9YGY3]

sequence


PR:000038165
mitotic checkpoint protein BUB3 isoform 2
BUB3/iso:2
"A mitotic checkpoint protein BUB3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43684-2 or a 1:1 ortholog thereof." [PRO:DNx]

organism-sequence


PR:O43684-2
mitotic checkpoint protein BUB3 isoform 2 (human)
hBUB3/iso:2
"A mitotic checkpoint protein BUB3 isoform 2 that is encoded in the genome of human." [PRO:DNx]

organism-sequence


PR:Q9WVA3-1
mitotic checkpoint protein BUB3 isoform 1 (mouse)
mBUB3/iso:1
"A mitotic checkpoint protein BUB3 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]

modification


PR:000035436
mitotic checkpoint protein BUB3 phosphorylated 1
BUB3/Phos:1
"A mitotic checkpoint protein BUB3 that has been phosphorylated by BUB1. Example: UniProtKB:O43684, Ser-18, MOD:00046." [PMID:20057499, PMID:7969164, PRO:DAN, PRO:KER]

organism-modification


PR:000035437
mitotic checkpoint protein BUB3 phosphorylated 1 (human)
hBUB3/Phos:1
"A mitotic checkpoint protein BUB3 phosphorylated 1 in human. Phosphorylated on the Ser residue within the motif D[YG]ISx[IV]K. UniProtKB:O43684, Ser-18, MOD:00046." [PMID:20057499, PRO:DAN, PRO:KER]
Yes
organism-modification


PR:000035438
cell cycle arrest protein BUB3 phosphorylated 1 (yeast)
yBUB3/Phos:1
"A mitotic checkpoint protein BUB3 phosphorylated 1 in yeast. UniProtKB:P26449, Ser-15, MOD:00046." [PMID:7969164, PRO:DAN, PRO:KER]

modification


PR:000035453
mitotic checkpoint protein BUB3 unphosphorylated form
BUB3/PhosRes-
"A mitotic checkpoint protein BUB3 that lacks phosphorylated residues." [PRO:KER]

organism-modification


PR:000035454
mitotic checkpoint protein BUB3 unphosphorylated form (human)
hBUB3/PhosRes-
"A mitotic checkpoint protein BUB3 unphosphorylated form in human." [PRO:KER]

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BUB3 forms found in complexes   

BUB3 Component
 Complexes
PR:O42860 Spom972h-BUB3 PR:000035569 BUB1:BUB3 complex (Schizosaccharomyces pombe 972h-)
PR:O43684 hBUB3 PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:000035563 BUB1B:BUB3 complex (human)
PR:000035564 BUB1:BUB3 complex (human)
PR:000035567 BUB1:BUB3:MAD1L1 complex (human)
PR:000035576 BUB1:BUB3:APC complex (human)
PR:P26449 yBUB3 PR:000035565 BUB1:BUB3 complex (yeast)
PR:Q9YGY3 frog-BUB3 PR:000035512 BUB1B:BUB3:MAD2:CDC20 complex (frog)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035437 hBUB3/Phos:1
UniProtKB:O43684, Ser-18, MOD:00046		 acts_upstream_of_or_withinincreased GO:0012501 programmed cell death relative to PR:000035454 hBUB3/PhosRes- PMID:20057499
PR:O43684 hBUB3 enablesGO:0005515 protein binding with PR:O15350-1 PMID:10198256
GO:0005515 protein binding with PR:O15350-2 PMID:10198256
GO:0005515 protein binding with PR:O15350-3 PMID:10198256
GO:0005515 protein binding with PR:O15350-5 PMID:10198256
GO:0005515 protein binding with PR:O43683 BUB1 PMID:10198256
GO:0005515 protein binding with PR:O60566 BUB1B PMID:10198256
GO:0005515 protein binding with PR:P25054 APC PMID:10198256
GO:0005515 protein binding with PR:Q12834 CDC20 PMID:10198256
GO:0005515 protein binding with PR:Q13257 hMAD2L1 PMID:10198256
GO:0005515 protein binding with PR:Q9Y6D9 hMAD1 PMID:10198256
located_inGO:0000776 kinetochore PMID:11283619
PR:P26449 yBUB3 acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:15514023
enablesGO:0005515 protein binding with PR:000035536 UniProtKB:P53148, Thr-149/Thr-172/Thr-235, MOD:00047 PMID:22521787
located_inGO:0000776 kinetochore PMID:22521787