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Protein Ontology report - centromere-associated protein E
PR:000005326 - http://purl.obolibrary.org/obo/PR_000005326
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000005326   
  PRO namecentromere-associated protein E 
  Synonyms
PRO-Short-label: EXACT:CENPE
Other: EXACT:CENP-E | centromere protein E | KIF10 | kinesin superfamily protein 10 | kinesin-related protein CENPE | motor domain of KIF10
  Definition"A protein that is a translation product of the human CENPE gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000005326

centromere-associated protein E

CENPE


"A protein that is a translation product of the human CENPE gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O42263

centromere-associated protein E (frog)

frog-CENPE


"A centromere-associated protein E that is encoded in the genome of frog." [PRO:CNA]


organism-gene



PR:P34367

uncharacterized protein C50C3.2 (worm)

CENPE (worm)


"A centromere-associated protein E that is encoded in the genome of worm." [OMA:P34367, PRO:DNx]


organism-gene



PR:Q02224

centromere-associated protein E (human)

hCENPE


"A centromere-associated protein E that is encoded in the genome of human." [PMID:12719470, PMID:15592459, PMID:17785528, PRO:KER]

Yes

organism-sequence



PR:Q02224-1

centromere-associated protein E isoform h1 (human)

hCENPE/iso:h1


"A centromere-associated protein E (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02224-1." [PRO:DNx, UniProtKB:Q02224]


organism-sequence



PR:Q02224-3

centromere-associated protein E isoform h3 (human)

hCENPE/iso:h3


"A centromere-associated protein E (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02224-3." [PRO:DNx, UniProtKB:Q02224]


organism-modification



PR:000065456

centromere-associated protein E deaminated 1 (human)

hCENPE/Deam:1


"A centromere-associated protein E (human) that has been deaminated on the residue at the position equivalent to Gln-1907 of the amino acid sequence represented by UniProtKB:Q02224-1. Example: UniProtKB:Q02224-1, Gln-1907, MOD:00685." [IEDB_epitope:1342778, PRO:DNx]


organism-modification



PR:000072868

centromere-associated protein E phosphorylated 1 (human)

hCENPE/Phos:1


"A centromere-associated protein E (human) that has been phosphorylated on the residue at the position equivalent to Thr-2540 of the amino acid sequence represented by UniProtKB:Q02224-1. Example: UniProtKB:Q02224-1, Thr-2540, MOD:00047." [IEDB_epitope:2149369, PRO:DNx]


organism-modification



PR:000077661

centromere-associated protein E deaminated 2 (human)

hCENPE/Deam:2


"A centromere-associated protein E (human) that has been deaminated on the residue at the position equivalent to Gln-977 of the amino acid sequence represented by UniProtKB:Q02224-1. Example: UniProtKB:Q02224-1, Gln-977, MOD:00685." [IEDB_epitope:1974671, PRO:DNx]


organism-modification



PR:000078565

centromere-associated protein E, mature form (human)

hCENPE/mature


"A centromere-associated protein E (human) that has had the propeptide removed. Example: UniProtKB:Q02224-1, 1-2698." [PRO:DNx, Reactome:R-HSA-376245]


organism-modification



PR:000080776

centromere-associated protein E cysteinylated 1 (human)

hCENPE/Cyst:1


"A centromere-associated protein E (human) that has been cysteinylated on the residue at the position equivalent to Cys-2162 of the amino acid sequence represented by UniProtKB:Q02224-1. Example: UniProtKB:Q02224-1, Cys-2162, MOD:00765." [IEDB_epitope:1582779, PRO:DNx]


organism-modification



PR:000082966

centromere-associated protein E methylated 1 (human)

hCENPE/Me:1


"A centromere-associated protein E (human) that has been methylated on the residue at the position equivalent to Cys-2297 of the amino acid sequence represented by UniProtKB:Q02224-1. Example: UniProtKB:Q02224-1, Cys-2297, MOD:00660." [IEDB_epitope:1023726, PRO:DNx]


organism-gene



PR:Q27IK7

kinesin-like protein KIN-12C (Arabidopsis thaliana)

At-CENPE


"A centromere-associated protein E that is encoded in the genome of Arabidopsis thaliana." [PRO:DNx]


organism-gene



PR:Q54NP8

kinesin-related protein 4 (Dictyostelium discoideum)

Dicty-CENPE


"A centromere-associated protein E that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54NP8, PRO:DNx]


organism-gene



PR:Q6RT24

centromere-associated protein E (mouse)

mCENPE


"A centromere-associated protein E that is encoded in the genome of mouse." [OMA:Q6RT24, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q02224 hCENPE acts_upstream_of_or_withinGO:0033674 positive regulation of kinase activity PMID:22801780
GO:0034501 protein localization to kinetochore PMID:17785528
GO:0051310 metaphase chromosome alignment PMID:15592459
enablesGO:0005515 protein binding with PR:O60566 BUB1B BioGRID:BG-545452; IntAct:EBI-1646673
GO:0005515 protein binding with PR:P49454 AH antigen (human) BioGRID:BG-545452; IntAct:EBI-1646673
GO:0005515 protein binding with PR:Q9BZD4 CDCA1 BioGRID:BG-545452; IntAct:EBI-1646673
located_inGO:0000776 kinetochore PMID:12719470