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Protein Ontology report - disabled homolog 2
PR:000006259 - http://purl.obolibrary.org/obo/PR_000006259
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000006259   
  PRO namedisabled homolog 2 
  Synonyms
PRO-Short-label: EXACT:DAB2
Gene-based: RELATED:DOC2
Other: EXACT:adaptor molecule disabled-2 | differentially expressed in ovarian carcinoma 2 | differentially-expressed protein 2 | DOC-2 | mitogen-responsive phosphoprotein
  Definition"A protein that is a translation product of the human DAB2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 8                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000006259
disabled homolog 2
DAB2
"A protein that is a translation product of the human DAB2 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:O88797
disabled homolog 2 (rat)
rDAB2
"A disabled homolog 2 that is encoded in the genome of rat." [OMA:O88797, PRO:DNx]

organism-sequence


PR:O88797-1
disabled homolog 2 isoform rp82 (rat)
rDAB2/iso:rp82
"A disabled homolog 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88797-1." [PRO:DNx, UniProtKB:O88797]

organism-sequence


PR:O88797-2
disabled homolog 2 isoform rp59 (rat)
rDAB2/iso:rp59
"A disabled homolog 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88797-2." [PRO:DNx, UniProtKB:O88797]

organism-gene


PR:P98078
disabled homolog 2 (mouse)
mDAB2
"A disabled homolog 2 that is encoded in the genome of mouse." [OMA:P98078, PRO:DNx]

organism-sequence


PR:P98078-1
disabled homolog 2 isoform 1 (mouse)
mDAB2/iso:1
"A disabled homolog 2 isoform 1 that is encoded in the genome of mouse." [PMID:7775479, PRO:HJD]
Yes
organism-sequence


PR:P98078-2
disabled homolog 2 isoform 2 (mouse)
mDAB2/iso:2
"A disabled homolog 2 isoform 2 that is encoded in the genome of mouse." [PMID:7775479, PRO:HJD]

organism-sequence


PR:P98078-3
disabled homolog 2 isoform 3 (mouse)
mDAB2/iso:3
"A disabled homolog 2 isoform 3 that is encoded in the genome of mouse." [PMID:7775479, PRO:HJD]
Yes
organism-gene


PR:P98082
disabled homolog 2 (human)
hDAB2
"A disabled homolog 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P98082]

organism-sequence


PR:P98082-1
disabled homolog 2 isoform h1 (human)
hDAB2/iso:h1
"A disabled homolog 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98082-1." [PRO:DNx, UniProtKB:P98082]

organism-sequence


PR:P98082-2
disabled homolog 2 isoform h2 (human)
hDAB2/iso:h2
"A disabled homolog 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98082-2." [PRO:DNx, UniProtKB:P98082]

organism-sequence


PR:P98082-3
disabled homolog 2 isoform h3 (human)
hDAB2/iso:h3
"A disabled homolog 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98082-3." [PRO:DNx, UniProtKB:P98082]

organism-modification


PR:000045861
disabled homolog 2 phosphorylated 1 (human)
hDAB2/Phos:1
"A disabled homolog 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-24 of the amino acid sequence represented by UniProtKB:P98082-1. Example: UniProtKB:P98082-1, Ser-24, MOD:00046." [iPTMnet:P98082, PMID:10542228]

organism-modification


PR:000071905
disabled homolog 2 deaminated 1 (human)
hDAB2/Deam:1
"A disabled homolog 2 (human) that has been deaminated on the residue at the position equivalent to Gln-386 of the amino acid sequence represented by UniProtKB:P98082-1. Example: UniProtKB:P98082-1, Gln-386, MOD:00685." [IEDB_epitope:1352324, PRO:DNx]

organism-modification


PR:000071990
disabled homolog 2 phosphorylated 2 (human)
hDAB2/Phos:2
"A disabled homolog 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-281 of the amino acid sequence represented by UniProtKB:P98082-1. Example: UniProtKB:P98082-1, Ser-281, MOD:00046." [IEDB_epitope:635221, PRO:DNx]

organism-modification


PR:000081123
disabled homolog 2 deaminated 2 (human)
hDAB2/Deam:2
"A disabled homolog 2 (human) that has been deaminated on the residue at the position equivalent to Asn-246 of the amino acid sequence represented by UniProtKB:P98082-1. Example: UniProtKB:P98082-1, Asn-246, MOD:00684." [IEDB_epitope:1994210, PRO:DNx]

sequence


PR:000028976
disabled homolog 2 isoform 1
DAB2/iso:1
"A disabled homolog 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98078-1 or a 1:1 ortholog thereof." [PMID:7775479, PRO:HJD]

organism-sequence


PR:P98078-1
disabled homolog 2 isoform 1 (mouse)
mDAB2/iso:1
"A disabled homolog 2 isoform 1 that is encoded in the genome of mouse." [PMID:7775479, PRO:HJD]
Yes
sequence


PR:000028978
disabled homolog 2 isoform 2
DAB2/iso:2
"A disabled homolog 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98078-2 or a 1:1 ortholog thereof." [PMID:7775479, PRO:HJD]

organism-sequence


PR:P98078-2
disabled homolog 2 isoform 2 (mouse)
mDAB2/iso:2
"A disabled homolog 2 isoform 2 that is encoded in the genome of mouse." [PMID:7775479, PRO:HJD]

sequence


PR:000028980
disabled homolog 2 isoform 3
DAB2/iso:3
"A disabled homolog 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98078-3 or a 1:1 ortholog thereof." [PMID:7775479, PRO:HJD]

organism-sequence


PR:P98078-3
disabled homolog 2 isoform 3 (mouse)
mDAB2/iso:3
"A disabled homolog 2 isoform 3 that is encoded in the genome of mouse." [PMID:7775479, PRO:HJD]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P98078-1 mDAB2/iso:1 acts_upstream_of_or_withinGO:0006907 pinocytosis MGI_ref:3610714; PMID:16263760
GO:0007492 endoderm development MGI_ref:5319713; PMID:22525672
GO:0007492 endoderm development MGI_ref:5319713; PMID:22525672
located_inGO:0005737 cytoplasm MGI_ref:1929027; PMID:11104669
PR:P98078-3 mDAB2/iso:3 acts_upstream_of_or_withinNOT GO:0007492 endoderm development MGI_ref:5319713; PMID:22525672
enablesGO:0005515 protein binding with PR:Q8C5D8-2 MGI_ref:1929027; PMID:11104669
located_inGO:0005634 nucleus MGI_ref:1929027; PMID:11104669