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Protein Ontology report - disrupted in schizophrenia 1 protein
PR:000006494 - http://purl.obolibrary.org/obo/PR_000006494
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000006494   
  PRO namedisrupted in schizophrenia 1 protein 
  Synonyms
PRO-Short-label: EXACT:DISC1
Gene-based: RELATED:KIAA0457
  Definition"A protein that is a translation product of the human DISC1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 17                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000006494
disrupted in schizophrenia 1 protein
DISC1
"A protein that is a translation product of the human DISC1 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:Q810H6
disrupted in schizophrenia 1 homolog (rat)
rDISC1
"A disrupted in schizophrenia 1 protein that is encoded in the genome of rat." [OMA:Q810H6, PRO:DNx]

organism-sequence


PR:Q810H6-1
disrupted in schizophrenia 1 homolog isoform r1 (rat)
rDISC1/iso:r1
"A disrupted in schizophrenia 1 homolog (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q810H6-1." [PRO:DNx, UniProtKB:Q810H6]

organism-sequence


PR:Q810H6-2
disrupted in schizophrenia 1 homolog isoform r2 (rat)
rDISC1/iso:r2
"A disrupted in schizophrenia 1 homolog (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q810H6-2." [PRO:DNx, UniProtKB:Q810H6]

organism-gene


PR:Q811T9
disrupted in schizophrenia 1 homolog (mouse)
mDISC1
"A disrupted in schizophrenia 1 protein that is encoded in the genome of mouse." [OMA:Q811T9, PRO:DNx]

organism-sequence


PR:Q811T9-1
disrupted in schizophrenia 1 protein isoform 1 (mouse)
mDISC1/iso:1
"A disrupted in schizophrenia 1 protein isoform 1 that is encoded in the genome of mouse." [PMID:21471969, PRO:KRC]

organism-modification


PR:000035602
disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 (mouse)
mDISC1/iso:1/Phos:1
"A disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 in mouse. UniProtKB:Q811T9-1, Ser-710, MOD:00046." [PMID:21471969, PRO:KRC]
Yes
organism-modification


PR:000035654
disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form (mouse)
mDISC1/iso:1/PhosRes-
"A disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form in mouse." [PMID:21471969, PRO:KRC]
Yes
organism-sequence


PR:Q811T9-2
disrupted in schizophrenia 1 protein isoform 2 (mouse)
mDISC1/iso:2
"A disrupted in schizophrenia 1 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q811T9-2." [PMID:12506198, PRO:HJD]

organism-sequence


PR:Q811T9-3
disrupted in schizophrenia 1 protein isoform 3 (mouse)
mDISC1/iso:3
"A disrupted in schizophrenia 1 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q811T9-3." [PMID:12504857, PRO:HJD]

organism-sequence


PR:Q811T9-4
disrupted in schizophrenia 1 protein isoform 4 (mouse)
mDISC1/iso:4
"A disrupted in schizophrenia 1 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q811T9-4." [PMID:12573262, PRO:HJD]

organism-gene


PR:Q9NRI5
disrupted in schizophrenia 1 protein (human)
hDISC1
"A disrupted in schizophrenia 1 protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-1
disrupted in schizophrenia 1 protein isoform h1 (human)
hDISC1/iso:h1
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-1." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-10
disrupted in schizophrenia 1 protein isoform h10 (human)
hDISC1/iso:h10
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-10." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-11
disrupted in schizophrenia 1 protein isoform h11 (human)
hDISC1/iso:h11
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-11." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-2
disrupted in schizophrenia 1 protein isoform h2 (human)
hDISC1/iso:h2
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-2." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-3
disrupted in schizophrenia 1 protein isoform h3 (human)
hDISC1/iso:h3
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-3." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-4
disrupted in schizophrenia 1 protein isoform h4 (human)
hDISC1/iso:h4
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-4." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-5
disrupted in schizophrenia 1 protein isoform h5 (human)
hDISC1/iso:h5
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-5." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-6
disrupted in schizophrenia 1 protein isoform h6 (human)
hDISC1/iso:h6
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-6." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-7
disrupted in schizophrenia 1 protein isoform h7 (human)
hDISC1/iso:h7
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-7." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-8
disrupted in schizophrenia 1 protein isoform h8 (human)
hDISC1/iso:h8
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-8." [PRO:DNx, UniProtKB:Q9NRI5]

organism-sequence


PR:Q9NRI5-9
disrupted in schizophrenia 1 protein isoform h9 (human)
hDISC1/iso:h9
"A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-9." [PRO:DNx, UniProtKB:Q9NRI5]

sequence


PR:000035601
disrupted in schizophrenia 1 protein isoform 1
DISC1/iso:1
"A disrupted in schizophrenia 1 protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q811T9-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:Q811T9-1
disrupted in schizophrenia 1 protein isoform 1 (mouse)
mDISC1/iso:1
"A disrupted in schizophrenia 1 protein isoform 1 that is encoded in the genome of mouse." [PMID:21471969, PRO:KRC]

organism-modification


PR:000035602
disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 (mouse)
mDISC1/iso:1/Phos:1
"A disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 in mouse. UniProtKB:Q811T9-1, Ser-710, MOD:00046." [PMID:21471969, PRO:KRC]
Yes
organism-modification


PR:000035654
disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form (mouse)
mDISC1/iso:1/PhosRes-
"A disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form in mouse." [PMID:21471969, PRO:KRC]
Yes
modification


PR:000035600
disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1
DISC1/iso:1/Phos:1
"A disrupted in schizophrenia 1 protein isoform 1 that has been phosphorylated on a residue equivalent to Ser-710 of the amino acid sequence represented by UniProtKB:Q811T9-1. Example: UniProtKB:Q811T9-1, Ser-710, MOD:00046." [PMID:21471969, PRO:KRC]

organism-modification


PR:000035602
disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 (mouse)
mDISC1/iso:1/Phos:1
"A disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 in mouse. UniProtKB:Q811T9-1, Ser-710, MOD:00046." [PMID:21471969, PRO:KRC]
Yes
modification


PR:000035653
disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form
DISC1/iso:1/PhosRes-
"A disrupted in schizophrenia 1 protein isoform 1 that lacks phosphorylated residues." [PRO:KRC]

organism-modification


PR:000035654
disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form (mouse)
mDISC1/iso:1/PhosRes-
"A disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form in mouse." [PMID:21471969, PRO:KRC]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035602 mDISC1/iso:1/Phos:1
UniProtKB:Q811T9-1, Ser-710, MOD:00046		 acts_upstream_of_or_withinGO:0008104 intracellular protein localization MGI_ref:5002731; PMID:21471969
enablesGO:0005515 protein binding with PR:Q3V3N7 Bardet-Biedl syndrome 1 protein homolog (mouse) MGI_ref:5002731; PMID:21471969
located_inGO:0005813 centrosome MGI_ref:5002731; PMID:21471969
PR:000035654 mDISC1/iso:1/PhosRes- acts_upstream_of_or_withinGO:0060070 canonical Wnt signaling pathway MGI_ref:5002731; PMID:21471969
enablesGO:0005515 protein binding with PR:Q9WV60 GSK-3 beta (mouse) MGI_ref:5002731; PMID:21471969