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Protein Ontology report - pre-pro-epidermal growth factor
PR:000006928 - http://purl.obolibrary.org/obo/PR_000006928
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000006928   
  PRO namepre-pro-epidermal growth factor 
  Synonyms
PRO-Short-label: EXACT:pre-pro-EGF
Gene-based: RELATED:EGF
Other: RELATED:epidermal growth factor | pro-epidermal growth factor
  Definition"A protein that is a translation product of the human EGF gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000006928
pre-pro-epidermal growth factor
pre-pro-EGF
"A protein that is a translation product of the human EGF gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:P01132
pro-epidermal growth factor (mouse)
mpre-pro-EGF
"A pre-pro-epidermal growth factor that is encoded in the genome of mouse." [OMA:P01132, PRO:DNx]

organism-gene


PR:P01133
pre-pro-epidermal growth factor (human)
hEGF
"A pre-pro-epidermal growth factor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01133]

organism-sequence


PR:P01133-1
pre-pro-epidermal growth factor isoform h1 (human)
hEGF/iso:h1
"A pre-pro-epidermal growth factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01133-1." [PRO:DNx, UniProtKB:P01133]

organism-sequence


PR:P01133-2
pre-pro-epidermal growth factor isoform h2 (human)
hEGF/iso:h2
"A pre-pro-epidermal growth factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01133-2." [PRO:DNx, UniProtKB:P01133]

organism-sequence


PR:P01133-3
pre-pro-epidermal growth factor isoform h3 (human)
hEGF/iso:h3
"A pre-pro-epidermal growth factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01133-3." [PRO:DNx, UniProtKB:P01133]

organism-modification


PR:000047260
pro-epidermal growth factor (human)
hEGF/SigPep-
"A pre-pro-epidermal growth factor (human) that has had the signal peptide removed. UniProtKB:P01133, 23-1207." [PRO:DNx, Reactome:R-HSA-139875, Reactome:R-HSA-179888, Reactome:R-HSA-54209]

organism-modification


PR:000051633
pro-epidermal growth factor O-glycosylated 1 (human)
hEGF/OGlyco:1
"A pre-pro-epidermal growth factor (human) that has been O-glycosylated at the residue equivalent to Ser-807 of the amino acid sequence represented by UniProtKB:P01133-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01133-1, 23-1207, Ser-807, MOD:00002~GNO:G43417UB." [GlyGen:P01133-1, PMID:22171320, PRO:DNx]

organism-modification


PR:000051634
pro-epidermal growth factor O-glycosylated 2 (human)
hEGF/OGlyco:2
"A pre-pro-epidermal growth factor (human) that has been O-glycosylated at the residue equivalent to Ser-954 of the amino acid sequence represented by UniProtKB:P01133-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01133-1, 23-1207, Ser-954, MOD:00002~GNO:G43417UB." [GlyGen:P01133-1, PMID:22171320, PRO:DNx]

organism-modification


PR:000051635
pro-epidermal growth factor O-glycosylated 3 (human)
hEGF/OGlyco:3
"A pre-pro-epidermal growth factor (human) that has been O-glycosylated at the residue equivalent to Ser-954 of the amino acid sequence represented by UniProtKB:P01133-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P01133-1, 23-1207, Ser-954, MOD:00002~GNO:G53434XO." [GlyGen:P01133-1, PMID:22171320, PRO:DNx]

organism-modification


PR:000051636
pro-epidermal growth factor O-glycosylated 4 (human)
hEGF/OGlyco:4
"A pre-pro-epidermal growth factor (human) that has been O-glycosylated at the residue equivalent to Thr-801 of the amino acid sequence represented by UniProtKB:P01133-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01133-1, 23-1207, Thr-801, MOD:00005~GNO:G43417UB." [GlyGen:P01133-1, PMID:22171320, PRO:DNx]

organism-modification


PR:000051637
pro-epidermal growth factor O-glycosylated 5 (human)
hEGF/OGlyco:5
"A pre-pro-epidermal growth factor (human) that has been O-glycosylated at the residue equivalent to Thr-955 of the amino acid sequence represented by UniProtKB:P01133-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01133-1, 23-1207, Thr-955, MOD:00005~GNO:G43417UB." [GlyGen:P01133-1, PMID:22171320, PRO:DNx]

organism-modification


PR:000051638
pre-pro-epidermal growth factor O-glycosylated 6 (human)
hEGF/OGlyco:6
"A pre-pro-epidermal growth factor (human) that has been O-glycosylated at the residue equivalent to Thr-955 of the amino acid sequence represented by UniProtKB:P01133-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P01133-1, 23-1207, Thr-955, MOD:00005~GNO:G53434XO." [GlyGen:P01133-1, PMID:22171320, PRO:DNx]

organism-modification


PR:000080852
pre-pro-epidermal growth factor deaminated 1 (human)
hEGF/Deam:1
"A pre-pro-epidermal growth factor (human) that has been deaminated on the residue at the position equivalent to Gln-482 of the amino acid sequence represented by UniProtKB:P01133-1. Example: UniProtKB:P01133-1, Gln-482, MOD:00685." [IEDB_epitope:1354986, PRO:DNx]

organism-gene


PR:P07522
pro-epidermal growth factor (rat)
rpre-pro-EGF
"A pre-pro-epidermal growth factor that is encoded in the genome of rat." [OMA:P07522, PRO:DNx]

modification


PR:000060268
pro-epidermal growth factor
EGF/SigPep-
"A pre-pro-epidermal growth factor that has had the signal peptide removed. Example: UniProtKB:P01133, 23-1207." [PRO:DAN]

modification


PR:000060269
epidermal growth factor
EGF
"A pro-epidermal growth factor that has been cleaved to release an extracelluar 53aa segment proximal to the cell membrane. Example: UniProtKB:P01133, 971-1023." [PRO:DAN]

Yes
organism-modification


PR:000047260
pro-epidermal growth factor (human)
hEGF/SigPep-
"A pre-pro-epidermal growth factor (human) that has had the signal peptide removed. UniProtKB:P01133, 23-1207." [PRO:DNx, Reactome:R-HSA-139875, Reactome:R-HSA-179888, Reactome:R-HSA-54209]

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pre-pro-EGF forms found in complexes   

pre-pro-EGF Component
 Complexes
PR:000060269 EGF PR:000060270 epidermal growth factor receptor, EGF-bound form monomer