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Protein Ontology report - interferon-induced, double-stranded RNA-activated protein kinase
PR:000006959 -
http://purl.obolibrary.org/obo/PR_000006959
Protein Forms
Ontology Information
Show OBO stanza
PRO ID
PR:000006959
PRO name
interferon-induced, double-stranded RNA-activated protein kinase
Synonyms
PRO-Short-label
:
EXACT:
EIF2AK2
Gene-based
:
RELATED:
PKR | PRKR | Tik
Other
:
EXACT:
eIF-2A protein kinase 2 | eukaryotic translation initiation factor 2-alpha kinase 2 | interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | p68 kinase | protein kinase R | protein kinase RNA-activated | serine/threonine-protein kinase TIK | tyrosine-protein kinase EIF2AK2
Definition
"A protein that is a translation product of the human EIF2AK2 gene or a 1:1 ortholog thereof." [PRO:DNx]
PRO Category
gene
Parent
PR:000000001
protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
3
Sequence
0
Organism-Sequence
2
Modification
1
Organism-Modification
4
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
IUPHARobj:2016
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Protein Forms
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Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000006959
interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2
"A protein that is a translation product of the human EIF2AK2 gene or a 1:1 ortholog thereof." [PRO:DNx]
organism-gene
PR:P19525
interferon-induced, double-stranded RNA-activated protein kinase (human)
hEIF2AK2
"An interferon-induced, double-stranded RNA-activated protein kinase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P19525]
organism-sequence
PR:P19525-1
interferon-induced, double-stranded RNA-activated protein kinase isoform 1 (human)
hEIF2AK2/iso:1
"An interferon-induced, double-stranded RNA-activated protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19525-1." [PRO:DNx, UniProtKB:P19525]
organism-sequence
PR:P19525-2
interferon-induced, double-stranded RNA-activated protein kinase isoform h2 (human)
hEIF2AK2/iso:h2
"An interferon-induced, double-stranded RNA-activated protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19525-2." [PRO:DNx, UniProtKB:P19525]
organism-modification
PR:000045703
interferon-induced, double-stranded RNA-activated protein kinase phosphorylated 1 (human)
hEIF2AK2/Phos:1
"An interferon-induced, double-stranded RNA-activated protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-451 of the amino acid sequence represented by UniProtKB:P19525-1. Example: UniProtKB:P19525-1, Thr-451, MOD:00047." [iPTMnet:P19525, PMID:17404396]
organism-modification
PR:000047263
interferon-induced, double-stranded RNA-activated protein kinase, initiator methionine removed form (human)
hEIF2AK2/InitMet-
"An interferon-induced, double-stranded RNA-activated protein kinase (human) that has had the initiator methionine removed. UniProtKB:P19525, 2-551." [PRO:DNx, Reactome:R-HSA-168699]
organism-modification
PR:000064543
interferon-induced, double-stranded RNA-activated protein kinase, initiator methionine removed phosphorylated 1 (human)
hEIF2AK2/InitMet-/Phos:1
"An interferon-induced, double-stranded RNA-activated protein kinase (human) that has had the initiator methionine removed and that has been phosphorylated on the residues at the positions equivalent to Thr-88, Thr-89, Thr-90, Tyr-101, Tyr-162, Ser-242, Thr-255, Thr-258, Tyr-293, Thr-446, and Thr-451 of the amino acid sequence represented by UniProtKB:P19525-1. Example: UniProtKB:P19525-1, 2-551, Thr-88/Thr-89/Thr-90/Thr-255/Thr-258/Thr-446/Thr-451, MOD:00047|Tyr-101/Tyr-162/Tyr-293, MOD:00048|Ser-242, MOD:00046." [PRO:DNx, Reactome:R-HSA-9833834, Reactome:R-HSA-9836332]
organism-modification
PR:000077363
interferon-induced, double-stranded RNA-activated protein kinase cysteinylated 1 (human)
hEIF2AK2/Cyst:1
"An interferon-induced, double-stranded RNA-activated protein kinase (human) that has been cysteinylated on the residue at the position equivalent to Cys-485 of the amino acid sequence represented by UniProtKB:P19525-1. Example: UniProtKB:P19525-1, Cys-485, MOD:00765." [IEDB_epitope:926944, PRO:DNx]
organism-gene
PR:Q03963
interferon-induced, double-stranded RNA-activated protein kinase (mouse)
mEIF2AK2
"An interferon-induced, double-stranded RNA-activated protein kinase that is encoded in the genome of mouse." [OMA:Q03963, PRO:DNx]
organism-gene
PR:Q63184
interferon-induced, double-stranded RNA-activated protein kinase (rat)
rEIF2AK2
"An interferon-induced, double-stranded RNA-activated protein kinase that is encoded in the genome of rat." [PRO:DNx]
modification
PR:000019757
interferon-induced, double-stranded RNA-activated protein kinase, initiator methionine removed form
EIF2AK2/InitMet-
"An interferon-induced, double-stranded RNA-activated protein kinase that has had the initiator methionine removed." [PRO:DNx]
organism-modification
PR:000047263
interferon-induced, double-stranded RNA-activated protein kinase, initiator methionine removed form (human)
hEIF2AK2/InitMet-
"An interferon-induced, double-stranded RNA-activated protein kinase (human) that has had the initiator methionine removed. UniProtKB:P19525, 2-551." [PRO:DNx, Reactome:R-HSA-168699]
organism-modification
PR:000064543
interferon-induced, double-stranded RNA-activated protein kinase, initiator methionine removed phosphorylated 1 (human)
hEIF2AK2/InitMet-/Phos:1
"An interferon-induced, double-stranded RNA-activated protein kinase (human) that has had the initiator methionine removed and that has been phosphorylated on the residues at the positions equivalent to Thr-88, Thr-89, Thr-90, Tyr-101, Tyr-162, Ser-242, Thr-255, Thr-258, Tyr-293, Thr-446, and Thr-451 of the amino acid sequence represented by UniProtKB:P19525-1. Example: UniProtKB:P19525-1, 2-551, Thr-88/Thr-89/Thr-90/Thr-255/Thr-258/Thr-446/Thr-451, MOD:00047|Tyr-101/Tyr-162/Tyr-293, MOD:00048|Ser-242, MOD:00046." [PRO:DNx, Reactome:R-HSA-9833834, Reactome:R-HSA-9836332]
