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Protein Ontology report - forkhead box protein O1
PR:000007640 - http://purl.obolibrary.org/obo/PR_000007640
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000007640   
  PRO nameforkhead box protein O1 
  Synonyms
PRO-Short-label: EXACT:FOXO1
Gene-based: RELATED:FKHR | FOXO1A
Other: EXACT:forkhead box protein O1A | forkhead in rhabdomyosarcoma
  Definition"A protein that is a translation product of the human FOXO1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000007640

forkhead box protein O1

FOXO1


"A protein that is a translation product of the human FOXO1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:A3RK74

forkhead box protein O1-A (zebrafish)

z-FOXO1


"A forkhead box protein O1 that is encoded in the genome of zebrafish." [OMA:A3RK74, PRO:DNx]


organism-gene



PR:G3V7R4

forkhead box protein O1 (rat)

rFOXO1


"A forkhead box protein O1 that is encoded in the genome of rat." [OMA:G3V7R4, PRO:DNx]


organism-gene



PR:Q12778

forkhead box protein O1 (human)

hFOXO1


"A forkhead box protein O1 that is encoded in the genome of human." [PRO:PD]


organism-sequence



PR:Q12778-1

forkhead box protein O1 isoform 1 (human)

hFOXO1/iso:1


"A forkhead box protein O1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000027894

forkhead box protein O1 isoform 1 phosphorylated 1 (human)

hFOXO1/iso:1/Phos:1


"A forkhead box protein O1 isoform 1 phosphorylated 1 in human. UniProtKB:Q12778-1, Ser-249, MOD:00046." [PMID:18356527, PRO:PD]

Yes

organism-modification



PR:000027896

forkhead box protein O1 phosphorylated 2 (human)

hFOXO1/Phos:2


"A forkhead box protein O1 phosphorylated 2 in human. UniProtKB:Q12778, Thr-24, MOD:00047|Ser-256/Ser-319, MOD:00046." [PMID:10358075, PRO:PD]


organism-modification



PR:000045892

forkhead box protein O1 phosphorylated 1 (human)

hFOXO1/Phos:1


"A forkhead box protein O1 (human) that has been phosphorylated at Ser-212. UniProtKB:Q12778, Ser-212, MOD:00046." [iPTMnet:Q12778, PMID:19221179]


organism-modification



PR:000047446

forkhead box protein O1 phosphorylated 3 (human)

hFOXO1/Phos:3


"A forkhead box protein O1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-218 of the amino acid sequence represented by UniProtKB:Q12778. UniProtKB:Q12778, Ser-218, MOD:00046." [PRO:DAN, Reactome:R-HSA-5692651]


organism-modification



PR:000064154

forkhead box protein O1 acetylated 1 (human)

hFOXO1/Ac:1


"A forkhead box protein O1 (human) that has been acetylated on the residues at the positions equivalent to Lys-245, Lys-248, and Lys-265 of the amino acid sequence represented by UniProtKB:Q12778. UniProtKB:Q12778, Lys-245/Lys-248/Lys-265, MOD:00064." [PRO:DNx, Reactome:R-HSA-9626942]


organism-modification



PR:000066133

forkhead box protein O1 phosphorylated 4 (human)

hFOXO1/Phos:4


"A forkhead box protein O1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-170 of the amino acid sequence represented by UniProtKB:Q12778. UniProtKB:Q12778, Thr-170, MOD:00047." [IEDB_epitope:2145685, PRO:DNx]


organism-modification



PR:000072063

forkhead box protein O1 phosphorylated 5 (human)

hFOXO1/Phos:5


"A forkhead box protein O1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-318 of the amino acid sequence represented by UniProtKB:Q12778. UniProtKB:Q12778, Ser-318, MOD:00046." [IEDB_epitope:912487, PRO:DNx]


organism-modification



PR:000076560

forkhead box protein O1 cysteinylated 1 (human)

hFOXO1/Cyst:1


"A forkhead box protein O1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-584 of the amino acid sequence represented by UniProtKB:Q12778. UniProtKB:Q12778, Cys-584, MOD:00765." [IEDB_epitope:884323, PRO:DNx]


organism-modification



PR:000080326

forkhead box protein O1 phosphorylated 6 (human)

hFOXO1/Phos:6


"A forkhead box protein O1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-317 of the amino acid sequence represented by UniProtKB:Q12778. UniProtKB:Q12778, Thr-317, MOD:00047." [IEDB_epitope:611241, PRO:DNx]


organism-gene



PR:Q9R1E0

forkhead box protein O1 (mouse)

mFOXO1


"A forkhead box protein O1 that is encoded in the genome of mouse." [OMA:Q9R1E0, PRO:DNx]


organism-sequence



PR:Q9R1E0-1

forkhead box protein O1 isoform 1 (mouse)

mFOXO1/iso:1


"A forkhead box protein O1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000027868

forkhead box protein O1 isoform 1

FOXO1/iso:1


"A forkhead box protein O1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12778-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q12778-1

forkhead box protein O1 isoform 1 (human)

hFOXO1/iso:1


"A forkhead box protein O1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000027894

forkhead box protein O1 isoform 1 phosphorylated 1 (human)

hFOXO1/iso:1/Phos:1


"A forkhead box protein O1 isoform 1 phosphorylated 1 in human. UniProtKB:Q12778-1, Ser-249, MOD:00046." [PMID:18356527, PRO:PD]

Yes

organism-sequence



PR:Q9R1E0-1

forkhead box protein O1 isoform 1 (mouse)

mFOXO1/iso:1


"A forkhead box protein O1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000027893

forkhead box protein O1 isoform 1 phosphorylated 1

FOXO1/iso:1/Phos:1


"A forkhead box protein O1 isoform 1 that has been modified on a conserved Ser residue in the GKSPRRR motif at the C-terminus of the Forkhead box DNA-binding domain.This modification promotes FOXO1 activation and cell death in neurons. Example: UniProtKB:Q12778, Ser-249, MOD:00046." [PMID:18356527, PRO:PD]


organism-modification



PR:000027894

forkhead box protein O1 isoform 1 phosphorylated 1 (human)

hFOXO1/iso:1/Phos:1


"A forkhead box protein O1 isoform 1 phosphorylated 1 in human. UniProtKB:Q12778-1, Ser-249, MOD:00046." [PMID:18356527, PRO:PD]

Yes

modification



PR:000027895

forkhead box protein O1 phosphorylated 2

FOXO1/Phos:2


"A forkhead box protein O1 that has been modified at one Thr and two Ser residues, all situated within the canonical AKT1 kinase consensus RXRXX(S/T) motifs. Example: UniProtKB:Q12778, Thr-24, MOD:00047|Ser-256/Ser-319, MOD:00046." [PMID:10358075, PRO:PD]


organism-modification



PR:000027896

forkhead box protein O1 phosphorylated 2 (human)

hFOXO1/Phos:2


"A forkhead box protein O1 phosphorylated 2 in human. UniProtKB:Q12778, Thr-24, MOD:00047|Ser-256/Ser-319, MOD:00046." [PMID:10358075, PRO:PD]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027894 hFOXO1/iso:1/Phos:1
UniProtKB:Q12778-1, Ser-249, MOD:00046
acts_upstream_of_or_withinGO:0010628 positive regulation of gene expression PMID:18356527
enablesNOT GO:0071889 14-3-3 protein binding PMID:18356527
located_inGO:0005634 nucleus PMID:18356527