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Protein Ontology report - insulin-degrading enzyme
PR:000008886 - http://purl.obolibrary.org/obo/PR_000008886
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000008886   
  PRO nameinsulin-degrading enzyme 
  Synonyms
PRO-Short-label: EXACT:IDE
Other: EXACT:abeta-degrading protease | insulin protease | insulinase | insulysin
  Definition"A protein that is a translation product of the human IDE gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification1                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2371
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000008886

insulin-degrading enzyme

IDE


"A protein that is a translation product of the human IDE gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O14077

putative zinc protease mug138 (Schizosaccharomyces pombe 972h-)

Spom972h-IDE


"An insulin-degrading enzyme that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O14077, PRO:DNx]


organism-gene



PR:P14735

insulin-degrading enzyme (human)

hIDE


"An insulin-degrading enzyme that is encoded in the genome of human." [PRO:DNx, UniProtKB:P14735]


organism-sequence



PR:P14735-1

insulin-degrading enzyme isoform 1 (human)

hIDE/iso:1


"An insulin-degrading enzyme isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P14735-2

insulin-degrading enzyme isoform h2 (human)

hIDE/iso:h2


"An insulin-degrading enzyme (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14735-2." [PRO:DNx, UniProtKB:P14735]


organism-modification



PR:000047941

insulin-degrading enzyme ubiquitinated form (human)

hIDE/UbiqLys+


"An insulin-degrading enzyme (human) that includes at least one ubiquitinated lysine. UniProtKB:P14735, MOD:01148." [PRO:DNx, Reactome:R-HSA-6783095]


organism-modification



PR:000077933

insulin-degrading enzyme methylated 1 (human)

hIDE/Me:1


"An insulin-degrading enzyme (human) that has been methylated on the residue at the position equivalent to Cys-974 of the amino acid sequence represented by UniProtKB:P14735-1. Example: UniProtKB:P14735-1, Cys-974, MOD:00660." [IEDB_epitope:1012645, IEDB_epitope:1014571, PRO:DNx]


organism-modification



PR:000078388

insulin-degrading enzyme deaminated 1 (human)

hIDE/Deam:1


"An insulin-degrading enzyme (human) that has been deaminated on the residue at the position equivalent to Asn-805 of the amino acid sequence represented by UniProtKB:P14735-1. Example: UniProtKB:P14735-1, Asn-805, MOD:00684." [IEDB_epitope:494735, PRO:DNx]


organism-gene



PR:P22817

insulin-degrading enzyme (fruit fly)

fly-IDE


"An insulin-degrading enzyme that is encoded in the genome of fruit fly." [OMA:P22817, PRO:DNx]


organism-gene



PR:P35559

insulin-degrading enzyme (rat)

rIDE


"An insulin-degrading enzyme that is encoded in the genome of rat." [OMA:P35559, PRO:DNx]


organism-sequence



PR:P35559-1

insulin-degrading enzyme isoform 1 (rat)

rIDE/iso:1


"An insulin-degrading enzyme isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q06010

A-factor-processing enzyme (yeast)

yIDE


"An insulin-degrading enzyme that is encoded in the genome of yeast." [OMA:Q06010, PRO:DNx]


organism-gene



PR:Q9JHR7

insulin-degrading enzyme (mouse)

mIDE


"An insulin-degrading enzyme that is encoded in the genome of mouse." [OMA:Q9JHR7, PRO:DNx]


organism-sequence



PR:Q9JHR7-1

insulin-degrading enzyme isoform 1 (mouse)

mIDE/iso:1


"An insulin-degrading enzyme isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000038911

insulin-degrading enzyme isoform 1

IDE/iso:1


"An insulin-degrading enzyme that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14735-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P14735-1

insulin-degrading enzyme isoform 1 (human)

hIDE/iso:1


"An insulin-degrading enzyme isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P35559-1

insulin-degrading enzyme isoform 1 (rat)

rIDE/iso:1


"An insulin-degrading enzyme isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q9JHR7-1

insulin-degrading enzyme isoform 1 (mouse)

mIDE/iso:1


"An insulin-degrading enzyme isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


modification



PR:000020229

insulin-degrading enzyme, initiator methionine removed form

IDE/InitMet-


"An insulin-degrading enzyme that has had the initiator methionine removed." [PRO:DNx]