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Protein Ontology report - tyrosine-protein kinase JAK2
PR:000009197 - http://purl.obolibrary.org/obo/PR_000009197
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000009197   
  PRO nametyrosine-protein kinase JAK2 
  Synonyms
PRO-Short-label: EXACT:JAK2
Other: EXACT:JAK-2 | Janus kinase 2
  Definition"A Janus kinase that is a translation product of the human JAK2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000025748 Janus kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification1                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2048
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000009197

tyrosine-protein kinase JAK2

JAK2


"A Janus kinase that is a translation product of the human JAK2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O60674

tyrosine-protein kinase JAK2 (human)

hJAK2


"A tyrosine-protein kinase JAK2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60674]


organism-sequence



PR:000063727

tyrosine-protein kinase JAK2 sequence variant V617F (human)

hJAK2/var:V617F


"A tyrosine-protein kinase JAK2 (human) that has a Phe residue at the position equivalent to Val-617 of the amino acid sequence represented by UniProtKB:O60674. UniProtKB:O60674, Val-617, CHEBI:29997." [PRO:DNx, Reactome:R-HSA-5211269]


organism-sequence



PR:O60674-1

tyrosine-protein kinase JAK2 isoform 1 (human)

hJAK2/iso:1


"A tyrosine-protein kinase JAK2 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000025747

tyrosine-protein kinase JAK2 isoform 1 phosphorylated 1 (human)

hJAK2/iso:1/Phos:1


"A tyrosine-protein kinase JAK2 isoform 1 phosphorylated 1 in human. UniProtKB:O60674-1, Tyr-1007/Tyr-1008, MOD:00048." [OCA:JP, PDB:3E62, PDB:3E63, PDB:3E64, PMID:19019674]


organism-modification



PR:000048085

tyrosine-protein kinase JAK2 phosphorylated 2 (human)

hJAK2/Phos:2


"A tyrosine-protein kinase JAK2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-1007 of the amino acid sequence represented by UniProtKB:O60674. UniProtKB:O60674, Tyr-1007, MOD:00048." [PRO:DNx, Reactome:R-HSA-873799]


organism-modification



PR:000048086

tyrosine-protein kinase JAK2 phosphorylated 3 (human)

hJAK2/Phos:3


"A tyrosine-protein kinase JAK2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-813 of the amino acid sequence represented by UniProtKB:O60674. UniProtKB:O60674, Tyr-813, MOD:00048." [PRO:DNx, Reactome:R-HSA-997248]


organism-modification



PR:000048087

tyrosine-protein kinase JAK2 phosphorylated 4 (human)

hJAK2/Phos:4


"A tyrosine-protein kinase JAK2 (human) that has been post-translationally modified to include phosphotyrosine at positions 119, 221, 372, 373, 570, 637, 813, 868, 966, 972, 1007, and 1008 of the amino acid sequence represented by UniProtKB:O60674. UniProtKB:O60674, Tyr-119/Tyr-221/Tyr-372/Tyr-373/Tyr-570/Tyr-637/Tyr-813/Tyr-868/Tyr-966/Tyr-972/Tyr-1007/Tyr-1008, MOD:00048." [PRO:DNx, Reactome:R-HSA-2586516]


organism-modification



PR:000061668

tyrosine-protein kinase JAK2 phosphorylated form (human)

hJAK2/PhosRes+


"A tyrosine-protein kinase JAK2 (human) that includes at least one phosphorylated residue. UniProtKB:O60674, MOD:00696." [PRO:DNx, Reactome:R-HSA-210621]


organism-modification



PR:000063899

tyrosine-protein kinase JAK2 phosphorylated 1 (human)

hJAK2/Phos:1


"A tyrosine-protein kinase JAK2 (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-1007 and Tyr-1008 of the amino acid sequence represented by UniProtKB:O60674. UniProtKB:O60674, Tyr-1007/Tyr-1008, MOD:00048." [PRO:DNx, Reactome:R-HSA-9005327]


organism-gene



PR:Q62120

tyrosine-protein kinase JAK2 (mouse)

mJAK2


"A tyrosine-protein kinase JAK2 that is encoded in the genome of mouse." [OMA:Q62120, PRO:DNx]


organism-sequence



PR:Q62120-1

tyrosine-protein kinase JAK2 isoform 1 (mouse)

mJAK2/iso:1


"A tyrosine-protein kinase JAK2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q62689

tyrosine-protein kinase JAK2 (rat)

rJAK2


"A tyrosine-protein kinase JAK2 that is encoded in the genome of rat." [OMA:Q62689, PRO:DNx]


sequence



PR:000025745

tyrosine-protein kinase JAK2 isoform 1

JAK2/iso:1


"A tyrosine-protein kinase JAK2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60674-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:O60674-1

tyrosine-protein kinase JAK2 isoform 1 (human)

hJAK2/iso:1


"A tyrosine-protein kinase JAK2 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000025747

tyrosine-protein kinase JAK2 isoform 1 phosphorylated 1 (human)

hJAK2/iso:1/Phos:1


"A tyrosine-protein kinase JAK2 isoform 1 phosphorylated 1 in human. UniProtKB:O60674-1, Tyr-1007/Tyr-1008, MOD:00048." [OCA:JP, PDB:3E62, PDB:3E63, PDB:3E64, PMID:19019674]


organism-sequence



PR:Q62120-1

tyrosine-protein kinase JAK2 isoform 1 (mouse)

mJAK2/iso:1


"A tyrosine-protein kinase JAK2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000025746

tyrosine-protein kinase JAK2 isoform 1 phosphorylated 1

JAK2/iso:1/Phos:1


"A tyrosine-protein kinase JAK2 isoform 1 that has been phosphorylated by autocatalysis on the two consecutive Tyr residues within the activation loop of the most C-terminal protein kinase domain. Example: UniProtKB:O60674-1, Tyr-1007/Tyr-1008, MOD:00048." [PMID:15575979]


organism-modification



PR:000025747

tyrosine-protein kinase JAK2 isoform 1 phosphorylated 1 (human)

hJAK2/iso:1/Phos:1


"A tyrosine-protein kinase JAK2 isoform 1 phosphorylated 1 in human. UniProtKB:O60674-1, Tyr-1007/Tyr-1008, MOD:00048." [OCA:JP, PDB:3E62, PDB:3E63, PDB:3E64, PMID:19019674]