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Protein Ontology report - mitotic spindle assembly checkpoint protein MAD2A
PR:000010038 - http://purl.obolibrary.org/obo/PR_000010038
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010038   
  PRO namemitotic spindle assembly checkpoint protein MAD2A 
  Synonyms
PRO-Short-label: EXACT:MAD2L1
Gene-based: RELATED:MAD2 | Mad2a
Other: EXACT:MAD2-like protein 1 | mitotic arrest deficient 2-like protein 1
  Definition"A protein that is a translation product of the human MAD2L1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 8                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification1                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000010038 mitotic spindle assembly checkpoint protein MAD2A
MAD2L1

organism-gene


PR:O14417 mitotic spindle checkpoint component mad2 (Schizosaccharomyces pombe 972h-)
Spom972h-MAD2L1

Yes
organism-gene


PR:P40958 mitotic spindle checkpoint component MAD2 (yeast)
yMAD2L1
Yes
organism-gene


PR:P79935 mitotic spindle assembly checkpoint protein MAD2A (frog)
frog-MAD2L1

Yes
organism-gene


PR:Q13257 mitotic spindle assembly checkpoint protein MAD2A (human)
hMAD2L1
Yes
Yes
organism-sequence


PR:Q13257-1 mitotic spindle assembly checkpoint protein MAD2A isoform 1 (human)
hMAD2L1/iso:1

organism-sequence


PR:Q13257-2 mitotic spindle assembly checkpoint protein MAD2A isoform h2 (human)
hMAD2L1/iso:h2

organism-modification


PR:000042259 mitotic spindle assembly checkpoint protein MAD2A, initiator methionine removed form (human)
hMAD2L1/InitMet-

Yes
organism-modification


PR:000072513 mitotic spindle assembly checkpoint protein MAD2A deaminated 1 (human)
hMAD2L1/Deam:1

organism-modification


PR:000079488 mitotic spindle assembly checkpoint protein MAD2A hydroxylated 1 (human)
hMAD2L1/Hy:1

organism-modification


PR:000079874 mitotic spindle assembly checkpoint protein MAD2A deaminated 2 (human)
hMAD2L1/Deam:2

organism-modification


PR:000081542 mitotic spindle assembly checkpoint protein MAD2A acetylated 1 (human)
hMAD2L1/Ac:1

organism-modification


PR:000084143 mitotic spindle assembly checkpoint protein MAD2A hydroxylated 2 (human)
hMAD2L1/Hy:2

organism-gene


PR:Q556Y9 mitotic spindle assembly checkpoint protein MAD2A (Dictyostelium discoideum)
Dicty-MAD2L1

organism-gene


PR:Q59VQ3 spindle assembly checkpoint component MAD2 (Candida albicans SC5314)
Calb-MAD2L1

organism-gene


PR:Q9LU93 mitotic spindle checkpoint protein MAD2 (Arabidopsis thaliana)
At-MAD2L1

organism-sequence


PR:Q9LU93-1 mitotic spindle checkpoint protein MAD2 isoform 1 (Arabidopsis thaliana)
At-MAD2L1/iso:1

organism-gene


PR:Q9Z1B5 mitotic spindle assembly checkpoint protein MAD2A (mouse)
mMAD2L1

organism-sequence


PR:Q9Z1B5-1 mitotic spindle assembly checkpoint protein MAD2A isoform 1 (mouse)
mMAD2L1/iso:1

sequence


PR:000040405 mitotic spindle assembly checkpoint protein MAD2A isoform 1
MAD2L1/iso:1

organism-sequence


PR:Q13257-1 mitotic spindle assembly checkpoint protein MAD2A isoform 1 (human)
hMAD2L1/iso:1

organism-sequence


PR:Q9Z1B5-1 mitotic spindle assembly checkpoint protein MAD2A isoform 1 (mouse)
mMAD2L1/iso:1

modification


PR:000020518 mitotic spindle assembly checkpoint protein MAD2A, initiator methionine removed form
MAD2L1/InitMet-

organism-modification


PR:000042259 mitotic spindle assembly checkpoint protein MAD2A, initiator methionine removed form (human)
hMAD2L1/InitMet-

Yes
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MAD2L1 forms found in complexes   

MAD2L1 Component
 Complexes
PR:000042259 hMAD2L1/InitMet- PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:O14417 Spom972h-MAD2L1 PR:000035574 MAD2:MAD3 complex (Schizosaccharomyces pombe 972h-)
PR:P79935 frog-MAD2L1 PR:000035512 BUB1B:BUB3:MAD2:CDC20 complex (frog)
PR:Q13257 hMAD2L1 PR:000035568 MAD1:MAD2 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P40958 yMAD2L1 acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:15514023
GO:0031577 spindle checkpoint signaling PMID:17504936
PR:Q13257 hMAD2L1 acts_upstream_of_or_withinNOT GO:0051310 metaphase chromosome alignment PMID:15592459
GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
enablesGO:0005515 protein binding with PR:O43684 BUB3 BioGRID:BG-718929; MINT:MINT-8289277
GO:0005515 protein binding with PR:O60566 BUB1B BioGRID:BG-718929; MINT:MINT-8289277
GO:0005515 protein binding with PR:P25054 APC BioGRID:BG-718929; MINT:MINT-8289277
GO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-718929; MINT:MINT-8289277
GO:0005515 protein binding with PR:Q9Y6D9 hMAD1 BioGRID:BG-718929; MINT:MINT-8289277
GO:0031625 ubiquitin protein ligase binding PMID:20624902
GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
located_inGO:0000776 kinetochore PMID:12719470