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Protein Ontology report - dual specificity mitogen-activated protein kinase kinase 1
PR:000010125 - http://purl.obolibrary.org/obo/PR_000010125
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000010125   
  PRO namedual specificity mitogen-activated protein kinase kinase 1 
  Synonyms
PRO-Short-label: EXACT:MAP2K1
Gene-based: RELATED:MEK1 | PRKMK1
Other: EXACT:ERK activator kinase 1 | MAP kinase kinase 1 | MAPK/ERK kinase 1 | MAPKK 1 | MEK 1
  Definition"A protein that is a translation product of the human MAP2K1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification1                                                  Organism-Modification 26                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2062
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000010125

dual specificity mitogen-activated protein kinase kinase 1

MAP2K1


"A protein that is a translation product of the human MAP2K1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P29678

dual specificity mitogen-activated protein kinase kinase 1 (rabbit)

rabbit-MAP2K1


"A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of rabbit." [OMA:P29678, PRO:DNx]


organism-gene



PR:P31938

dual specificity mitogen-activated protein kinase kinase 1 (mouse)

mMAP2K1


"A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of mouse." [OMA:P31938, PRO:DNx]


organism-sequence



PR:P31938-1

dual specificity mitogen-activated protein kinase kinase 1 isoform 1 (mouse)

mMAP2K1/iso:1


"A dual specificity mitogen-activated protein kinase kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNx]


organism-gene



PR:Q01986

dual specificity mitogen-activated protein kinase kinase 1 (rat)

rMAP2K1


"A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of rat." [OMA:Q01986, PRO:DNx]


organism-gene



PR:Q02750

dual specificity mitogen-activated protein kinase kinase 1 (human)

hMAP2K1


"A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q02750]


organism-sequence



PR:Q02750-1

dual specificity mitogen-activated protein kinase kinase 1 isoform 1 (human)

hMAP2K1/iso:1


"A dual specificity mitogen-activated protein kinase kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNx]


organism-modification



PR:000026220

dual specificity mitogen-activated protein kinase kinase 1 isoform 1 phosphorylated 1 (human)

hMAP2K1/iso:1/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:Q02750-1, Ser-218/Ser-222, MOD:00046." [PMID:8131746, PRO:CNA]


organism-sequence



PR:Q02750-2

dual specificity mitogen-activated protein kinase kinase 1 isoform h2 (human)

hMAP2K1/iso:h2


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02750-2." [PRO:DNx, UniProtKB:Q02750]


organism-modification



PR:000045873

dual specificity mitogen-activated protein kinase kinase 1 phosphorylated 1 (human)

hMAP2K1/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-298 of the amino acid sequence represented by UniProtKB:Q02750-1. Example: UniProtKB:Q02750-1, Ser-298, MOD:00046." [iPTMnet:Q02750, PMID:11948406, PMID:18593598]


organism-modification



PR:000048292

dual specificity mitogen-activated protein kinase kinase 1, initiator methionine removed phosphorylated 1 (human)

hMAP2K1/InitMet-/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 218 and 222 of the amino acid sequence represented by UniProtKB:Q02750. UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046." [PRO:DNx, Reactome:R-HSA-109837]


organism-modification



PR:000048293

dual specificity mitogen-activated protein kinase kinase 1, initiator methionine removed phosphorylated 2 (human)

hMAP2K1/InitMet-/Phos:2


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 218 and 222, and phosphothreonine at positions 286 and 292 of the amino acid sequence represented by UniProtKB:Q02750. UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046|Thr-286/Thr-292, MOD:00047." [PRO:DNx, Reactome:R-HSA-112339]


organism-modification



PR:000048294

dual specificity mitogen-activated protein kinase kinase 1, initiator methionine removed phosphorylated 3 (human)

hMAP2K1/InitMet-/Phos:3


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 218 and 222, and phosphothreonine at position 292 of the amino acid sequence represented by UniProtKB:Q02750. UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046|Thr-292, MOD:00047." [PRO:DNx, Reactome:R-HSA-5674490]


organism-modification



PR:000048295

dual specificity mitogen-activated protein kinase kinase 1, initiator methionine removed phosphorylated 4 (human)

hMAP2K1/InitMet-/Phos:4


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 286 and 292 of the amino acid sequence represented by UniProtKB:Q02750. UniProtKB:Q02750, 2-393, Thr-286/Thr-292, MOD:00047." [PRO:DNx, Reactome:R-HSA-112374]


organism-modification



PR:000060664

dual specificity mitogen-activated protein kinase kinase 1 sequence variant Q56P, initiator methionine removed form (human)

hMAP2K1/var:Q56P/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Pro residue at the position equivalent to Gln-56 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Gln-56, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-9652064]


organism-modification



PR:000061077

dual specificity mitogen-activated protein kinase kinase 1 sequence variant D67N, initiator methionine removed form (human)

hMAP2K1/var:D67N/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has an Asn residue at the position equivalent to Asp-67 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Asp-67, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9652016]


organism-modification



PR:000061139

dual specificity mitogen-activated protein kinase kinase 1 sequence variant C121S, initiator methionine removed form (human)

hMAP2K1/var:C121S/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Ser residue at the position equivalent to Cys-121 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Cys-121, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-9652013]


organism-modification



PR:000061271

dual specificity mitogen-activated protein kinase kinase 1 sequence variant D67Y, initiator methionine removed form (human)

hMAP2K1/var:D67Y/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Tyr residue at the position equivalent to Asp-67 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Asp-67, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-9652019]


organism-modification



PR:000061444

dual specificity mitogen-activated protein kinase kinase 1 sequence variant F53V, initiator methionine removed form (human)

hMAP2K1/var:F53V/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Val residue at the position equivalent to Phe-53 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Phe-53, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652038]


organism-modification



PR:000061741

dual specificity mitogen-activated protein kinase kinase 1 sequence variant E203K, initiator methionine removed form (human)

hMAP2K1/var:E203K/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Lys residue at the position equivalent to Glu-203 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Glu-203, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-9652023]


organism-modification



PR:000061927

dual specificity mitogen-activated protein kinase kinase 1 sequence variant G128V, initiator methionine removed form (human)

hMAP2K1/var:G128V/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Val residue at the position equivalent to Gly-128 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Gly-128, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652047]


organism-modification



PR:000062169

dual specificity mitogen-activated protein kinase kinase 1 sequence variant F53Y, initiator methionine removed form (human)

hMAP2K1/var:F53Y/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Tyr residue at the position equivalent to Phe-53 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Phe-53, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-9652041]


organism-modification



PR:000062375

dual specificity mitogen-activated protein kinase kinase 1 sequence variant K57N, initiator methionine removed form (human)

hMAP2K1/var:K57N/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has an Asn residue at the position equivalent to Lys-57 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Lys-57, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9652050]


organism-modification



PR:000062727

dual specificity mitogen-activated protein kinase kinase 1 sequence variant P124L, initiator methionine removed form (human)

hMAP2K1/var:P124L/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Leu residue at the position equivalent to Pro-124 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Pro-124, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-9652056]


organism-modification



PR:000062811

dual specificity mitogen-activated protein kinase kinase 1 sequence variant K57T, initiator methionine removed form (human)

hMAP2K1/var:K57T/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Thr residue at the position equivalent to Lys-57 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Lys-57, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-9652052]


organism-modification



PR:000062854

dual specificity mitogen-activated protein kinase kinase 1 sequence variant V60E, initiator methionine removed form (human)

hMAP2K1/var:V60E/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Glu residue at the position equivalent to Val-60 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Val-60, CHEBI:29972." [PRO:DNx, Reactome:R-HSA-9652067]


organism-modification



PR:000063158

dual specificity mitogen-activated protein kinase kinase 1 sequence variant P124Q, initiator methionine removed form (human)

hMAP2K1/var:P124Q/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Gln residue at the position equivalent to Pro-124 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Pro-124, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-9652058]


organism-modification



PR:000063546

dual specificity mitogen-activated protein kinase kinase 1 sequence variant F53L, initiator methionine removed form (human)

hMAP2K1/var:F53L/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Leu residue at the position equivalent to Phe-53 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Phe-53, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-9652031]


organism-modification



PR:000063595

dual specificity mitogen-activated protein kinase kinase 1 sequence variant F53S, initiator methionine removed form (human)

hMAP2K1/var:F53S/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Ser residue at the position equivalent to Phe-53 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Phe-53, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-9652034]


organism-modification



PR:000063606

dual specificity mitogen-activated protein kinase kinase 1 sequence variant G128D, initiator methionine removed form (human)

hMAP2K1/var:G128D/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has an Asp residue at the position equivalent to Gly-128 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Gly-128, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-9652043]


organism-modification



PR:000063710

dual specificity mitogen-activated protein kinase kinase 1 sequence variant Y130C, initiator methionine removed form (human)

hMAP2K1/var:Y130C/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Cys residue at the position equivalent to Tyr-130 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Tyr-130, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-9652101]


organism-modification



PR:000064073

dual specificity mitogen-activated protein kinase kinase 1 sequence variant F53C, initiator methionine removed form (human)

hMAP2K1/var:F53C/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Cys residue at the position equivalent to Phe-53 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Phe-53, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-9652028]


organism-modification



PR:000064213

dual specificity mitogen-activated protein kinase kinase 1 sequence variant P124S, initiator methionine removed form (human)

hMAP2K1/var:P124S/InitMet-


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has a Ser residue at the position equivalent to Pro-124 of the amino acid sequence represented by UniProtKB:Q02750-1 and that has had the initiator methionine removed. Example: UniProtKB:Q02750-1, 2-393, Pro-124, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-9652062]


organism-modification



PR:000077881

dual specificity mitogen-activated protein kinase kinase 1 deaminated 1 (human)

hMAP2K1/Deam:1


"A dual specificity mitogen-activated protein kinase kinase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-354 of the amino acid sequence represented by UniProtKB:Q02750-1. Example: UniProtKB:Q02750-1, Gln-354, MOD:00685." [IEDB_epitope:1779907, PRO:DNx]


sequence



PR:000026194

dual specificity mitogen-activated protein kinase kinase 1 isoform 1

MAP2K1/iso:1


"A dual specificity mitogen-activated protein kinase kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02750-1 or a 1:1 ortholog thereof." [PRO:CNx]


organism-sequence



PR:P31938-1

dual specificity mitogen-activated protein kinase kinase 1 isoform 1 (mouse)

mMAP2K1/iso:1


"A dual specificity mitogen-activated protein kinase kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNx]


organism-sequence



PR:Q02750-1

dual specificity mitogen-activated protein kinase kinase 1 isoform 1 (human)

hMAP2K1/iso:1


"A dual specificity mitogen-activated protein kinase kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNx]


organism-modification



PR:000026220

dual specificity mitogen-activated protein kinase kinase 1 isoform 1 phosphorylated 1 (human)

hMAP2K1/iso:1/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:Q02750-1, Ser-218/Ser-222, MOD:00046." [PMID:8131746, PRO:CNA]


modification



PR:000026196

dual specificity mitogen-activated protein kinase kinase 1 isoform 1 phosphorylated 1

MAP2K1/iso:1/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 1 isoform 1 that has been phosphorylated in the two conserved Ser residues involved in kinase activation. Example: UniProtKB:Q02750-1, Ser-218/Ser-222, MOD:00046." [PMID:8131746, PRO:CNA]


organism-modification



PR:000026220

dual specificity mitogen-activated protein kinase kinase 1 isoform 1 phosphorylated 1 (human)

hMAP2K1/iso:1/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:Q02750-1, Ser-218/Ser-222, MOD:00046." [PMID:8131746, PRO:CNA]