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Protein Ontology report - mitogen-activated protein kinase 7
PR:000010159 - http://purl.obolibrary.org/obo/PR_000010159
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010159   
  PRO namemitogen-activated protein kinase 7 
  Synonyms
PRO-Short-label: EXACT:MAPK7
Gene-based: RELATED:BMK1 | ERK5 | PRKM7
Other: EXACT:Big MAP kinase 1 | BMK-1 | ERK-5 | extracellular signal-regulated kinase 5 | MAP kinase 7 | MAPK 7
  Definition"A protein that is a translation product of the human MAPK7 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2093
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000010159
mitogen-activated protein kinase 7
MAPK7
"A protein that is a translation product of the human MAPK7 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:P0C865
mitogen-activated protein kinase 7 (rat)
rMAPK7
"A mitogen-activated protein kinase 7 that is encoded in the genome of rat." [OMA:P0C865, PRO:DNx]

organism-gene


PR:Q13164
mitogen-activated protein kinase 7 (human)
hMAPK7
"A mitogen-activated protein kinase 7 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13164]

organism-sequence


PR:Q13164-1
mitogen-activated protein kinase 7 isoform 1 (human)
hMAPK7/iso:1
"A mitogen-activated protein kinase 7 isoform 1 that is encoded in the genome of human." [PMID:20832753, PRO:CNA]

organism-modification


PR:000026481
mitogen-activated protein kinase 7 isoform 1 phosphorylated 1 (human)
hMAPK7/iso:1/Phos:1
"A mitogen-activated protein kinase 7 isoform 1 phosphorylated 1 in human. UniProtKB:Q13164-1, Thr-28/Thr-219/Thr-733, MOD:00047|Tyr-221, MOD:00048|Ser-421/Ser-433/Ser-496/Ser-731, MOD:00046." [PMID:12628002, PMID:20832753, PRO:CNA]
Yes
organism-sequence


PR:Q13164-2
mitogen-activated protein kinase 7 isoform h2 (human)
hMAPK7/iso:h2
"A mitogen-activated protein kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13164-2." [PRO:DNx, UniProtKB:Q13164]

organism-sequence


PR:Q13164-3
mitogen-activated protein kinase 7 isoform h3 (human)
hMAPK7/iso:h3
"A mitogen-activated protein kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13164-3." [PRO:DNx, UniProtKB:Q13164]

organism-sequence


PR:Q13164-4
mitogen-activated protein kinase 7 isoform h4 (human)
hMAPK7/iso:h4
"A mitogen-activated protein kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13164-4." [PRO:DNx, UniProtKB:Q13164]

organism-modification


PR:000048326
mitogen-activated protein kinase 7, initiator methionine removed form (human)
hMAPK7/InitMet-
"A mitogen-activated protein kinase 7 (human) that has had the initiator methionine removed. UniProtKB:Q13164, 2-816." [PRO:DNx, Reactome:R-HSA-198754, Reactome:R-HSA-199961]

organism-modification


PR:000048327
mitogen-activated protein kinase 7, initiator methionine removed phosphorylated 2 (human)
hMAPK7/InitMet-/Phos:2
"A mitogen-activated protein kinase 7 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 219, and phosphotyrosine at position 221 of the amino acid sequence represented by UniProtKB:Q13164. UniProtKB:Q13164, 2-816, Thr-219, MOD:00047|Tyr-221, MOD:00048." [PMID:12628002, PRO:DAN, Reactome:R-HSA-198721, Reactome:R-HSA-198738]

organism-gene


PR:Q23023
serine/threonine-protein kinase unc-51 (worm)
MAPK7 (worm)
"A mitogen-activated protein kinase 7 that is encoded in the genome of worm." [OMA:Q23023, PRO:DNx]

organism-gene


PR:Q9WVS8
mitogen-activated protein kinase 7 (mouse)
mMAPK7
"A mitogen-activated protein kinase 7 that is encoded in the genome of mouse." [OMA:Q9WVS8, PRO:DNx]

organism-sequence


PR:Q9WVS8-1
mitogen-activated protein kinase 7 isoform 1 (mouse)
mMAPK7/iso:1
"A mitogen-activated protein kinase 7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-sequence


PR:Q9WVS8-2
mitogen-activated protein kinase 7 isoform m2 (mouse)
mMAPK7/iso:m2
"A mitogen-activated protein kinase 7 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WVS8-2." [PRO:DNx, UniProtKB:Q9WVS8]

organism-sequence


PR:Q9WVS8-3
mitogen-activated protein kinase 7 isoform m3 (mouse)
mMAPK7/iso:m3
"A mitogen-activated protein kinase 7 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WVS8-3." [PRO:DNx, UniProtKB:Q9WVS8]

organism-sequence


PR:Q9WVS8-4
mitogen-activated protein kinase 7 isoform m4 (mouse)
mMAPK7/iso:m4
"A mitogen-activated protein kinase 7 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WVS8-4." [PRO:DNx, UniProtKB:Q9WVS8]

organism-sequence


PR:Q9WVS8-5
mitogen-activated protein kinase 7 isoform m5 (mouse)
mMAPK7/iso:m5
"A mitogen-activated protein kinase 7 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WVS8-5." [PRO:DNx, UniProtKB:Q9WVS8]

sequence


PR:000026477
mitogen-activated protein kinase 7 isoform 1
MAPK7/iso:1
"A mitogen-activated protein kinase 7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13164-1 or a 1:1 ortholog thereof." [PMID:20832753, PRO:CNA]

organism-sequence


PR:Q13164-1
mitogen-activated protein kinase 7 isoform 1 (human)
hMAPK7/iso:1
"A mitogen-activated protein kinase 7 isoform 1 that is encoded in the genome of human." [PMID:20832753, PRO:CNA]

organism-modification


PR:000026481
mitogen-activated protein kinase 7 isoform 1 phosphorylated 1 (human)
hMAPK7/iso:1/Phos:1
"A mitogen-activated protein kinase 7 isoform 1 phosphorylated 1 in human. UniProtKB:Q13164-1, Thr-28/Thr-219/Thr-733, MOD:00047|Tyr-221, MOD:00048|Ser-421/Ser-433/Ser-496/Ser-731, MOD:00046." [PMID:12628002, PMID:20832753, PRO:CNA]
Yes
organism-sequence


PR:Q9WVS8-1
mitogen-activated protein kinase 7 isoform 1 (mouse)
mMAPK7/iso:1
"A mitogen-activated protein kinase 7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

modification


PR:000026479
mitogen-activated protein kinase 7 isoform 1 phosphorylated 1
MAPK7/iso:1/Phos:1
"A mitogen-activated protein kinase 7 isoform 1 that has been phosphorylated by activation of MAP kinase pathway." [PMID:20832753, PRO:CNA]

organism-modification


PR:000026481
mitogen-activated protein kinase 7 isoform 1 phosphorylated 1 (human)
hMAPK7/iso:1/Phos:1
"A mitogen-activated protein kinase 7 isoform 1 phosphorylated 1 in human. UniProtKB:Q13164-1, Thr-28/Thr-219/Thr-733, MOD:00047|Tyr-221, MOD:00048|Ser-421/Ser-433/Ser-496/Ser-731, MOD:00046." [PMID:12628002, PMID:20832753, PRO:CNA]
Yes
modification


PR:000026588
mitogen-activated protein kinase 7 isoform 1, initiator methionine removed form
MAPK7/iso:1/InitMet-
"A mitogen-activated protein kinase 7 isoform 1 that has had the initiator methionine removed." [PRO:DNx]

modification


PR:000026587
mitogen-activated protein kinase 7, initiator methionine removed form
MAPK7/InitMet-
"A mitogen-activated protein kinase 7 that has had the initiator methionine removed." [PRO:DNx]

modification


PR:000026588
mitogen-activated protein kinase 7 isoform 1, initiator methionine removed form
MAPK7/iso:1/InitMet-
"A mitogen-activated protein kinase 7 isoform 1 that has had the initiator methionine removed." [PRO:DNx]

organism-modification


PR:000048326
mitogen-activated protein kinase 7, initiator methionine removed form (human)
hMAPK7/InitMet-
"A mitogen-activated protein kinase 7 (human) that has had the initiator methionine removed. UniProtKB:Q13164, 2-816." [PRO:DNx, Reactome:R-HSA-198754, Reactome:R-HSA-199961]

organism-modification


PR:000048327
mitogen-activated protein kinase 7, initiator methionine removed phosphorylated 2 (human)
hMAPK7/InitMet-/Phos:2
"A mitogen-activated protein kinase 7 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 219, and phosphotyrosine at position 221 of the amino acid sequence represented by UniProtKB:Q13164. UniProtKB:Q13164, 2-816, Thr-219, MOD:00047|Tyr-221, MOD:00048." [PMID:12628002, PRO:DAN, Reactome:R-HSA-198721, Reactome:R-HSA-198738]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026481 hMAPK7/iso:1/Phos:1
UniProtKB:Q13164-1, Thr-28/Thr-219/Thr-733, MOD:00047|Tyr-221, MOD:00048|Ser-421/Ser-433/Ser-496/Ser-731, MOD:00046		 acts_upstream_of_or_withinGO:0008284 positive regulation of cell population proliferation PMID:20832753
enablesGO:0004707 MAP kinase activity PMID:20832753
GO:0005515 protein binding PMID:20832753
located_inGO:0005634 nucleus PMID:20832753