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Protein Ontology report - mannan-binding lectin serine protease 2
PR:000010194 - http://purl.obolibrary.org/obo/PR_000010194
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010194   
  PRO namemannan-binding lectin serine protease 2 
  Synonyms
PRO-Short-label: EXACT:MASP2
Other: EXACT:mannose-binding protein-associated serine protease 2 | MASP-2 | MBL-associated serine protease 2
  Definition"A protein that is a translation product of the human MASP2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000010194

mannan-binding lectin serine protease 2

MASP2


"A protein that is a translation product of the human MASP2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O00187

mannan-binding lectin serine protease 2 (human)

hMASP2


"A mannan-binding lectin serine protease 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O00187]


organism-sequence



PR:O00187-1

mannan-binding lectin serine protease 2 isoform 1 (human)

hMASP2/iso:1


"A mannan-binding lectin serine protease 2 isoform 1 that is encoded in the genome of human." [PMID:10092804, PRO:CNA]


organism-modification



PR:000064532

mannan-binding lectin serine protease 2 isoform 1, signal peptide removed form (human)

hMASP2/iso:1/SigPep-


"A mannan-binding lectin serine protease 2 isoform 1 (human) that has had the signal peptide removed. UniProtKB:O00187-1, 16-686." [PRO:DNx, Reactome:R-HSA-166689]


organism-sequence



PR:O00187-2

mannan-binding lectin serine protease 2 isoform 2 (human)

hMASP2/iso:2


"A mannan-binding lectin serine protease 2 isoform 2 that is encoded in the genome of human." [PMID:10092804, PRO:CNA]


organism-gene



PR:Q91WP0

mannan-binding lectin serine protease 2 (mouse)

mMASP2


"A mannan-binding lectin serine protease 2 that is encoded in the genome of mouse." [OMA:Q91WP0, PRO:DNx]


organism-sequence



PR:Q91WP0-1

mannan-binding lectin serine protease 2 isoform 1 (mouse)

mMASP2/iso:1


"A mannan-binding lectin serine protease 2 isoform 1 that is encoded in the genome of mouse." [PMID:9794427, PRO:HJD]

Yes

organism-sequence



PR:Q91WP0-2

mannan-binding lectin serine protease 2 isoform 2 (mouse)

mMASP2/iso:2


"A mannan-binding lectin serine protease 2 isoform 2 that is encoded in the genome of mouse. This form is shorter than isoform 1, differs in sequence at positions 182-185, and lacks residues 186 to 685." [PMID:10586086, PRO:HJD]

Yes

organism-gene



PR:Q9JJS8

mannan-binding lectin serine protease 2 (rat)

rMASP2


"A mannan-binding lectin serine protease 2 that is encoded in the genome of rat." [OMA:Q9JJS8, PRO:DNx]


organism-sequence



PR:Q9JJS8-1

mannan-binding lectin serine protease 2 isoform r1 (rat)

rMASP2/iso:r1


"A mannan-binding lectin serine protease 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJS8-1." [PRO:DNx, UniProtKB:Q9JJS8]


organism-sequence



PR:Q9JJS8-2

mannan-binding lectin serine protease 2 isoform r2 (rat)

rMASP2/iso:r2


"A mannan-binding lectin serine protease 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJS8-2." [PRO:DNx, UniProtKB:Q9JJS8]


sequence



PR:000037130

mannan-binding lectin serine protease 2 isoform 1

MASP2/iso:1


"A mannan-binding lectin serine protease 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91WP0-1 or a 1:1 ortholog thereof." [PMID:9794427, PRO:HJD]


organism-sequence



PR:O00187-1

mannan-binding lectin serine protease 2 isoform 1 (human)

hMASP2/iso:1


"A mannan-binding lectin serine protease 2 isoform 1 that is encoded in the genome of human." [PMID:10092804, PRO:CNA]


organism-modification



PR:000064532

mannan-binding lectin serine protease 2 isoform 1, signal peptide removed form (human)

hMASP2/iso:1/SigPep-


"A mannan-binding lectin serine protease 2 isoform 1 (human) that has had the signal peptide removed. UniProtKB:O00187-1, 16-686." [PRO:DNx, Reactome:R-HSA-166689]


organism-sequence



PR:Q91WP0-1

mannan-binding lectin serine protease 2 isoform 1 (mouse)

mMASP2/iso:1


"A mannan-binding lectin serine protease 2 isoform 1 that is encoded in the genome of mouse." [PMID:9794427, PRO:HJD]

Yes

sequence



PR:000037133

mannan-binding lectin serine protease 2 isoform 2

MASP2/iso:2


"A mannan-binding lectin serine protease 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91WP0-2 or a 1:1 ortholog thereof." [PMID:10586086, PRO:HJD]


organism-sequence



PR:O00187-2

mannan-binding lectin serine protease 2 isoform 2 (human)

hMASP2/iso:2


"A mannan-binding lectin serine protease 2 isoform 2 that is encoded in the genome of human." [PMID:10092804, PRO:CNA]


organism-sequence



PR:Q91WP0-2

mannan-binding lectin serine protease 2 isoform 2 (mouse)

mMASP2/iso:2


"A mannan-binding lectin serine protease 2 isoform 2 that is encoded in the genome of mouse. This form is shorter than isoform 1, differs in sequence at positions 182-185, and lacks residues 186 to 685." [PMID:10586086, PRO:HJD]

Yes

modification



PR:000020544

mannan-binding lectin serine protease 2 proteolytic cleavage product

MASP2/ClvPrd


"A mannan-binding lectin serine protease 2 that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q91WP0-1 mMASP2/iso:1 acts_upstream_of_or_withinGO:0001867 complement activation, lectin pathway MGI_ref:5473786; PMID:16328467
enablesGO:0005515 protein binding with PR:O70165-1 MGI_ref:5473786; PMID:16328467
PR:Q91WP0-2 mMASP2/iso:2
This form is shorter than isoform 1, differs in sequence at positions 182-185, and lacks residues 186 to 685
enablesGO:0005515 protein binding with PR:O70165-1 MGI_ref:5473786; PMID:16328467