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Protein Ontology report - mediator of DNA damage checkpoint protein 1
PR:000010258 - http://purl.obolibrary.org/obo/PR_000010258
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000010258   
  PRO namemediator of DNA damage checkpoint protein 1 
  Synonyms
PRO-Short-label: EXACT:MDC1
Gene-based: RELATED:KIAA0170 | NFBD1
Other: EXACT:nuclear factor with BRCT domains 1
  Definition"A protein that is a translation product of the human MDC1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000010258

mediator of DNA damage checkpoint protein 1

MDC1


"A protein that is a translation product of the human MDC1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q14676

mediator of DNA damage checkpoint protein 1 (human)

hMDC1


"A mediator of DNA damage checkpoint protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q14676]


organism-sequence



PR:Q14676-1

mediator of DNA damage checkpoint protein 1 isoform h1 (human)

hMDC1/iso:h1


"A mediator of DNA damage checkpoint protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14676-1." [PRO:DNx, UniProtKB:Q14676]


organism-sequence



PR:Q14676-2

mediator of DNA damage checkpoint protein 1 isoform h2 (human)

hMDC1/iso:h2


"A mediator of DNA damage checkpoint protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14676-2." [PRO:DNx, UniProtKB:Q14676]


organism-sequence



PR:Q14676-3

mediator of DNA damage checkpoint protein 1 isoform h3 (human)

hMDC1/iso:h3


"A mediator of DNA damage checkpoint protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14676-3." [PRO:DNx, UniProtKB:Q14676]


organism-sequence



PR:Q14676-4

mediator of DNA damage checkpoint protein 1 isoform h4 (human)

hMDC1/iso:h4


"A mediator of DNA damage checkpoint protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14676-4." [PRO:DNx, UniProtKB:Q14676]


organism-modification



PR:000045929

mediator of DNA damage checkpoint protein 1 phosphorylated 1 (human)

hMDC1/Phos:1


"A mediator of DNA damage checkpoint protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-98 of the amino acid sequence represented by UniProtKB:Q14676-1. Example: UniProtKB:Q14676-1, Thr-98, MOD:00047." [iPTMnet:Q14676, PMID:21705321]


organism-modification



PR:000048353

mediator of DNA damage checkpoint protein 1 phosphorylated 2 (human)

hMDC1/Phos:2


"A mediator of DNA damage checkpoint protein 1 (human) that has been post-translationally modified to include phosphothreonine at positions 4, 699, 719, 752 and 765 of the amino acid sequence represented by UniProtKB:Q14676. UniProtKB:Q14676, Thr-4/Thr-699/Thr-719/Thr-752/Thr-765, MOD:00047." [PRO:DNx, Reactome:R-HSA-75236]


organism-modification



PR:000064720

mediator of DNA damage checkpoint protein 1 sumoylated 1 (human)

hMDC1/Sumo:1


"A mediator of DNA damage checkpoint protein 1 (human) that has been sumoylated on the residue at the position equivalent to Lys-1840 of the amino acid sequence represented by UniProtKB:Q14676-1. Example: UniProtKB:Q14676-1, Lys-1840, MOD:01149." [PRO:DNx, Reactome:R-HSA-4570473, Reactome:R-HSA-4570546]


organism-modification



PR:000064766

mediator of DNA damage checkpoint protein 1 phosphorylated and sumoylated 1 (human)

hMDC1/PhosSumo:1


"A mediator of DNA damage checkpoint protein 1 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-4, Thr-699, Thr-719, Thr-752 and Thr-765, and sumoylated on the residue at the position equivalent to Lys-1840 of the amino acid sequence represented by UniProtKB:Q14676-1. Example: UniProtKB:Q14676-1, Thr-4/Thr-699/Thr-719/Thr-752/Thr-765, MOD:00047|Lys-1840, MOD:01149." [PRO:DNx, Reactome:R-HSA-5684061]


organism-modification



PR:000064784

mediator of DNA damage checkpoint protein 1 phosphorylated, sumoylated, and ubiquitinated 1 (human)

hMDC1/PhosSumoUbiq:1


"A mediator of DNA damage checkpoint protein 1 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-4, Thr-699, Thr-719, Thr-752 and Thr-765, and sumoylated on the residue at the position equivalent to Lys-1840 of the amino acid sequence represented by UniProtKB:Q14676-1 and that includes at least one ubiquitinated lysine. Example: UniProtKB:Q14676-1, Thr-4/Thr-699/Thr-719/Thr-752/Thr-765, MOD:00047|Lys-1840, MOD:01149|MOD:01148." [PRO:DNx, Reactome:R-HSA-5684074]


organism-modification



PR:000078098

mediator of DNA damage checkpoint protein 1 methylated 1 (human)

hMDC1/Me:1


"A mediator of DNA damage checkpoint protein 1 (human) that has been methylated on the residue at the position equivalent to Cys-62 of the amino acid sequence represented by UniProtKB:Q14676-1. Example: UniProtKB:Q14676-1, Cys-62, MOD:00660." [IEDB_epitope:1043895, PRO:DNx]


organism-gene



PR:Q5PSV9

mediator of DNA damage checkpoint protein 1 (mouse)

mMDC1


"A mediator of DNA damage checkpoint protein 1 that is encoded in the genome of mouse." [OMA:Q5PSV9, PRO:DNx]


organism-gene



PR:Q5U2M8

mediator of DNA damage checkpoint protein 1 (rat)

rMDC1


"A mediator of DNA damage checkpoint protein 1 that is encoded in the genome of rat." [OMA:Q5U2M8, PRO:DNx]