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Protein Ontology report - neurogenic locus notch homolog protein 1
PR:000011331 - http://purl.obolibrary.org/obo/PR_000011331
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000011331   
  PRO nameneurogenic locus notch homolog protein 1 
  Synonyms
PRO-Short-label: EXACT:NOTCH1
Gene-based: RELATED:Motch | TAN1
Other: EXACT:motch A | N1 | neurogenic locus notch protein 1 | notch 1 | translocation-associated notch protein TAN-1
RELATED:T14
  Definition"A NOTCH protein that is a translation product of the human NOTCH1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000050044 NOTCH protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification1                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2861
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000011331
neurogenic locus notch homolog protein 1
NOTCH1
"A NOTCH protein that is a translation product of the human NOTCH1 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:P07207
neurogenic locus Notch protein (fruit fly)
fly-NOTCH1
"A neurogenic locus notch homolog protein 1 that is encoded in the genome of fruit fly." [PRO:DNx]

organism-gene


PR:P46531
neurogenic locus notch homolog protein 1 (human)
hNOTCH1
"A neurogenic locus notch homolog protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P46531]

organism-modification


PR:000048623
neurogenic locus notch homolog protein 1, signal peptide removed form (human)
hNOTCH1/SigPep-
"A neurogenic locus notch homolog protein 1 (human) that has had the signal peptide removed. UniProtKB:P46531, 19-2555." [PRO:DNx, Reactome:R-HSA-157024]

organism-modification


PR:000060807
neurogenic locus notch homolog protein 1, signal peptide removed O-glycosylated 1 (human)
hNOTCH1/SigPep-/OGlyco:1
"A neurogenic locus notch homolog protein 1 (human) that has had the signal peptide removed and that has been O-glycosylated on the residues at the positions equivalent to Thr-73, Thr-116, Thr-232, Thr-311, Thr-349, Thr-466, Thr-617, Thr-692, Thr-767, Thr-805, Ser-883, Ser-921, Thr-997, Thr-1035, Thr-1159, Thr-1197, Thr-1243, Thr-1362, and Thr-1402 of the amino acid sequence represented by UniProtKB:P46531. UniProtKB:P46531, 19-2555, Thr-73/Thr-116/Thr-232/Thr-311/Thr-349/Thr-466/Thr-617/Thr-692/Thr-767/Thr-805/Thr-997/Thr-1035/Thr-1159/Thr-1197/Thr-1243/Thr-1362/Thr-1402, MOD:00813|Ser-883/Ser-921, MOD:00812." [PRO:DNx, Reactome:R-HSA-1467396]

organism-modification


PR:000085782
neurogenic locus notch homolog protein 1, signal peptide removed O-glycosylated 2 (human)
hNOTCH1/SigPep-/OGlyco:2
"A neurogenic locus notch homolog protein 1 (human) that has had the signal peptide removed and that has been O-glycosylated on the residues at the positions equivalent to Thr-73, Thr-116, Ser-146, Thr-232, Thr-311, Thr-349, Ser-378, Ser-458, Thr-466, Ser-496, Ser-534, Ser-609, Thr-617, Ser-647, Thr-692, Ser-722, Ser-759, Thr-767, Ser-797, Thr-805, Ser-883, Ser-921, Thr-997, Ser-1027, Thr-1035, Ser-1065, Thr-1159, Ser-1189, Thr-1197, Thr-1243, Ser-1273, Thr-1362, and Thr-1402 of the amino acid sequence represented by UniProtKB:P46531. UniProtKB:P46531, 19-2555, Thr-73/Thr-116/Thr-232/Thr-311/Thr-349/Thr-466/Thr-617/Thr-692/Thr-767/Thr-805/Thr-997/Thr-1035/Thr-1159/Thr-1197/Thr-1243/Thr-1362/Thr-1402, MOD:00813|Ser-146/Ser-378/Ser-458/Ser-496/Ser-534/Ser-609/Ser-647/Ser-722/Ser-759/Ser-797/Ser-1027/Ser-1065/Ser-1189/Ser-1273, MOD:00804|Ser-883/Ser-921, MOD:00812." [PRO:DNx, Reactome:R-HSA-1472872]

organism-modification


PR:000085899
neurogenic locus notch homolog protein 1, signal peptide removed O-glycosylated 3 (human)
hNOTCH1/SigPep-/OGlyco:3
"A neurogenic locus notch homolog protein 1 (human) that has had the signal peptide removed and that has been O-glycosylated on the residues at the positions equivalent to Thr-73, Thr-116, Ser-146, Thr-194, Thr-232, Thr-311, Thr-349, Ser-378, Ser-458, Thr-466, Ser-496, Ser-534, Ser-609, Thr-617, Ser-647, Thr-692, Ser-722, Ser-759, Thr-767, Ser-797, Thr-805, Ser-883, Ser-921, Thr-997, Ser-1027, Thr-1035, Ser-1065, Thr-1159, Ser-1189, Thr-1197, Thr-1243, Ser-1273, Thr-1321, Thr-1362, and Thr-1402 of the amino acid sequence represented by UniProtKB:P46531. UniProtKB:P46531, 19-2555, Thr-73/Thr-116/Thr-194/Thr-232/Thr-311/Thr-349/Thr-466/Thr-617/Thr-692/Thr-767/Thr-805/Thr-997/Thr-1035/Thr-1159/Thr-1197/Thr-1243/Thr-1321/Thr-1362/Thr-1402, MOD:00813|Ser-146/Ser-378/Ser-458/Ser-496/Ser-534/Ser-609/Ser-647/Ser-722/Ser-759/Ser-797/Ser-1027/Ser-1065/Ser-1189/Ser-1273, MOD:00804|Ser-883/Ser-921, MOD:00812." [PRO:DNx, Reactome:R-HSA-1467425]

organism-modification


PR:000066938
neurogenic locus notch homolog protein 1 methylated 1 (human)
hNOTCH1/Me:1
"A neurogenic locus notch homolog protein 1 (human) that has been methylated on the residue at the position equivalent to Cys-2308 of the amino acid sequence represented by UniProtKB:P46531. UniProtKB:P46531, Cys-2308, MOD:00660." [IEDB_epitope:1016141, PRO:DNx]

organism-modification


PR:000072525
neurogenic locus notch homolog protein 1 deaminated 1 (human)
hNOTCH1/Deam:1
"A neurogenic locus notch homolog protein 1 (human) that has been deaminated on the residue at the position equivalent to Gln-228 of the amino acid sequence represented by UniProtKB:P46531. UniProtKB:P46531, Gln-228, MOD:00685." [IEDB_epitope:1818914, PRO:DNx]

organism-modification


PR:000072670
neurogenic locus notch homolog protein 1 cysteinylated 1 (human)
hNOTCH1/Cyst:1
"A neurogenic locus notch homolog protein 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-1752 of the amino acid sequence represented by UniProtKB:P46531. UniProtKB:P46531, Cys-1752, MOD:00765." [IEDB_epitope:1562822, IEDB_epitope:1571434, IEDB_epitope:1571436, PRO:DNx]

organism-modification


PR:000082577
neurogenic locus notch homolog protein 1 O-glycosylated 1 (human)
hNOTCH1/OGlyco:1
"A neurogenic locus notch homolog protein 1 (human) that has been O-glycosylated on the residue at the position equivalent to Ser-2467 of the amino acid sequence represented by UniProtKB:P46531. UniProtKB:P46531, Ser-2467, MOD:00002." [IEDB_epitope:1074983, PRO:DNx]

organism-gene


PR:Q01705
neurogenic locus notch homolog protein 1 (mouse)
mNOTCH1
"A neurogenic locus notch homolog protein 1 that is encoded in the genome of mouse." [OMA:Q01705, PRO:DNx]

organism-sequence


PR:Q01705-1
neurogenic locus notch homolog protein 1 isoform 1 (mouse)
mNOTCH1/iso:1
"A neurogenic locus notch homolog protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

organism-sequence


PR:Q01705-2
neurogenic locus notch homolog protein 1 isoform m2 (mouse)
mNOTCH1/iso:m2
"A neurogenic locus notch homolog protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01705-2." [PRO:DNx, UniProtKB:Q01705]

organism-sequence


PR:Q01705-3
neurogenic locus notch homolog protein 1 isoform m3 (mouse)
mNOTCH1/iso:m3
"A neurogenic locus notch homolog protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01705-3." [PRO:DNx, UniProtKB:Q01705]

organism-sequence


PR:Q01705-4
neurogenic locus notch homolog protein 1 isoform m4 (mouse)
mNOTCH1/iso:m4
"A neurogenic locus notch homolog protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01705-4." [PRO:DNx, UniProtKB:Q01705]

organism-modification


PR:000085743
notch 1 intracellular domain (mouse)
mNOTCH1/NICD
"A neurogenic locus notch homolog protein 1 (mouse) that corresponds to the C-terminal portion after proteolytic cleavage by PSEN1 or PSEN2. UniProtKB:Q01705, 1744-2531." [PMID:10882062, PMID:11459941, PMID:11518718, PRO:DAN, UniProtKB:Q01705]

organism-gene


PR:Q07008
neurogenic locus notch homolog protein 1 (rat)
rNOTCH1
"A neurogenic locus notch homolog protein 1 that is encoded in the genome of rat." [OMA:Q07008, PRO:DNx]

organism-sequence


PR:Q07008-1
neurogenic locus notch homolog protein 1 isoform 1 (rat)
rNOTCH1/iso:1
"A neurogenic locus notch homolog protein 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]

sequence


PR:000040231
neurogenic locus notch homolog protein 1 isoform 1
NOTCH1/iso:1
"A neurogenic locus notch homolog protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01705-1 or a 1:1 ortholog thereof." [PRO:DNx]

organism-sequence


PR:Q01705-1
neurogenic locus notch homolog protein 1 isoform 1 (mouse)
mNOTCH1/iso:1
"A neurogenic locus notch homolog protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

organism-sequence


PR:Q07008-1
neurogenic locus notch homolog protein 1 isoform 1 (rat)
rNOTCH1/iso:1
"A neurogenic locus notch homolog protein 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]

modification


PR:000020763
neurogenic locus notch homolog protein 1 proteolytic cleavage product
NOTCH1/ClvPrd
"A neurogenic locus notch homolog protein 1 that has been processed by proteolytic cleavage." [PRO:DNx]

organism-modification


PR:000085743
notch 1 intracellular domain (mouse)
mNOTCH1/NICD
"A neurogenic locus notch homolog protein 1 (mouse) that corresponds to the C-terminal portion after proteolytic cleavage by PSEN1 or PSEN2. UniProtKB:Q01705, 1744-2531." [PMID:10882062, PMID:11459941, PMID:11518718, PRO:DAN, UniProtKB:Q01705]