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Protein Ontology report - phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
PR:000012719 - http://purl.obolibrary.org/obo/PR_000012719
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000012719   
  PRO namephosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 
  Synonyms
PRO-Short-label: EXACT:PIK3CA
Other: EXACT:p110alpha | phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha | phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha | phosphoinositide-3-kinase catalytic alpha polypeptide | PI3-kinase subunit alpha | PI3K-alpha | PI3Kalpha | PtdIns-3-kinase subunit alpha | PtdIns-3-kinase subunit p110-alpha | serine/threonine protein kinase PIK3CA
  Definition"A protein that is a translation product of the human PIK3CA gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 28                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2153
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000012719
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
PIK3CA
"A protein that is a translation product of the human PIK3CA gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:A0A0G2K344
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (rat)
rPIK3CA
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is encoded in the genome of rat." [OMA:A0A0G2K344, PRO:DNx]

organism-gene


PR:P32871
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (cow)
cow-PIK3CA
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is encoded in the genome of cow." [OMA:P32871, PRO:DNx]

organism-gene


PR:P42336
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human)
hPIK3CA
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is encoded in the genome of human." [PRO:DNx, UniProtKB:P42336]

organism-sequence


PR:000060518
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant R38S (human)
hPIK3CA/var:R38S
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Ser residue at the position equivalent to Arg-38 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Arg-38, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-2395947]

organism-sequence


PR:000060637
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant H1047L (human)
hPIK3CA/var:H1047L
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Leu residue at the position equivalent to His-1047 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, His-1047, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-1500714]

organism-sequence


PR:000060830
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant M1043I (human)
hPIK3CA/var:M1043I
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has an Ile residue at the position equivalent to Met-1043 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Met-1043, CHEBI:30009." [PRO:DNx, Reactome:R-HSA-1500719]

organism-sequence


PR:000060999
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant E545Q (human)
hPIK3CA/var:E545Q
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Gln residue at the position equivalent to Glu-545 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Glu-545, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-2362362]

organism-sequence


PR:000061203
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant H1047R (human)
hPIK3CA/var:H1047R
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has an Arg residue at the position equivalent to His-1047 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, His-1047, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-1500716]

organism-sequence


PR:000061269
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant E545K (human)
hPIK3CA/var:E545K
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Lys residue at the position equivalent to Glu-545 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Glu-545, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-1500706]

organism-sequence


PR:000061321
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant E542Q (human)
hPIK3CA/var:E542Q
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Gln residue at the position equivalent to Glu-542 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Glu-542, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-2328003]

organism-sequence


PR:000061334
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant R38H (human)
hPIK3CA/var:R38H
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a His residue at the position equivalent to Arg-38 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Arg-38, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-1500718]

organism-sequence


PR:000061341
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant Q546K (human)
hPIK3CA/var:Q546K
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Lys residue at the position equivalent to Gln-546 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Gln-546, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-1500705]

organism-sequence


PR:000061863
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant R38C (human)
hPIK3CA/var:R38C
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Cys residue at the position equivalent to Arg-38 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Arg-38, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-1500691]

organism-sequence


PR:000061977
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant Q546P (human)
hPIK3CA/var:Q546P
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Pro residue at the position equivalent to Gln-546 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Gln-546, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-1500695]

organism-sequence


PR:000062022
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant H1047Y (human)
hPIK3CA/var:H1047Y
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Tyr residue at the position equivalent to His-1047 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, His-1047, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-1500720]

organism-sequence


PR:000062332
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant Q546R (human)
hPIK3CA/var:Q546R
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has an Arg residue at the position equivalent to Gln-546 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Gln-546, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-2362373]

organism-sequence


PR:000062862
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant E545G (human)
hPIK3CA/var:E545G
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Gly residue at the position equivalent to Glu-545 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Glu-545, CHEBI:29947." [PRO:DNx, Reactome:R-HSA-1500709]

organism-sequence


PR:000063026
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant Q546E (human)
hPIK3CA/var:Q546E
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Glu residue at the position equivalent to Gln-546 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Gln-546, CHEBI:29972." [PRO:DNx, Reactome:R-HSA-2362383]

organism-sequence


PR:000063279
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant E545V (human)
hPIK3CA/var:E545V
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Val residue at the position equivalent to Glu-545 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Glu-545, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-2362365]

organism-sequence


PR:000063430
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant M1043V (human)
hPIK3CA/var:M1043V
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Val residue at the position equivalent to Met-1043 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Met-1043, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-2395932]

organism-sequence


PR:000063599
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant E542K (human)
hPIK3CA/var:E542K
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Lys residue at the position equivalent to Glu-542 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Glu-542, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-1500701]

organism-sequence


PR:000063725
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant E542V (human)
hPIK3CA/var:E542V
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Val residue at the position equivalent to Glu-542 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Glu-542, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-2328074]

organism-sequence


PR:000063784
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant R38G (human)
hPIK3CA/var:R38G
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Gly residue at the position equivalent to Arg-38 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Arg-38, CHEBI:29947." [PRO:DNx, Reactome:R-HSA-2395950]

organism-sequence


PR:000063884
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant Q546H (human)
hPIK3CA/var:Q546H
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a His residue at the position equivalent to Gln-546 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Gln-546, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-2362374]

organism-sequence


PR:000063984
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant Q546L (human)
hPIK3CA/var:Q546L
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Leu residue at the position equivalent to Gln-546 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Gln-546, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-2362375]

organism-sequence


PR:000064407
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant M1043T (human)
hPIK3CA/var:M1043T
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has a Thr residue at the position equivalent to Met-1043 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Met-1043, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-2395934]

organism-sequence


PR:000064552
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform sequence variant E545A (human)
hPIK3CA/var:E545A
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has an Ala residue at the position equivalent to Glu-545 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Glu-545, CHEBI:46217." [PRO:DNx, Reactome:R-HSA-2362355]

organism-sequence


PR:P42336-1
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform 1 (human)
hPIK3CA/iso:1
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-modification


PR:000079637
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform phosphorylated 1 (human)
hPIK3CA/Phos:1
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) that has been phosphorylated on the residue at the position equivalent to Ser-681 of the amino acid sequence represented by UniProtKB:P42336. UniProtKB:P42336, Ser-681, MOD:00046." [IEDB_epitope:912227, PRO:DNx]

organism-gene


PR:P42337
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (mouse)
mPIK3CA
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is encoded in the genome of mouse." [OMA:P42337, PRO:DNx]

organism-sequence


PR:P42337-1
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform 1 (mouse)
mPIK3CA/iso:1
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

sequence


PR:000039437
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform 1
PIK3CA/iso:1
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42336-1 or a 1:1 ortholog thereof." [PRO:DNx]

organism-sequence


PR:P42336-1
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform 1 (human)
hPIK3CA/iso:1
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-sequence


PR:P42337-1
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform 1 (mouse)
mPIK3CA/iso:1
"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform 1 that is encoded in the genome of mouse." [PRO:DNx]