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Protein Ontology report - sentrin-specific protease 2
PR:000014636 - http://purl.obolibrary.org/obo/PR_000014636
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000014636   
  PRO namesentrin-specific protease 2 
  Synonyms
PRO-Short-label: EXACT:SENP2
Gene-based: RELATED:KIAA1331 | Smt3ip2 | Supr1
Other: EXACT:Axam2 | sentrin/SUMO-specific protease SENP2 | SMT3-specific isopeptidase 2 | SUMO-1 protease 1 | SUMO-1/Smt3-specific isopeptidase 2 | SuPr-1
  Definition"A protein that is a translation product of the human SENP2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000014636

sentrin-specific protease 2

SENP2


"A protein that is a translation product of the human SENP2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q91ZX6

sentrin-specific protease 2 (mouse)

mSENP2


"A sentrin-specific protease 2 that is encoded in the genome of mouse." [OMA:Q91ZX6, PRO:DNx]


organism-sequence



PR:Q91ZX6-1

sentrin-specific protease 2 isoform 1 (mouse)

mSENP2/iso:1


"A sentrin-specific protease 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91ZX6-1." [PMID:16141072, PMID:19090619, PRO:HJD, UniProtKB:Q91ZX6]

Yes

organism-sequence



PR:Q91ZX6-2

sentrin-specific protease 2 isoform 2 (mouse)

mSENP2/iso:2


"A sentrin-specific protease 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91ZX6-2." [PMID:11489887, PMID:19090619, PRO:HJD, UniProtKB:Q91ZX6]

Yes

organism-sequence



PR:Q91ZX6-3

sentrin-specific protease 2 isoform 3 (mouse)

mSENP2/iso:3


"A sentrin-specific protease 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91ZX6-3." [PMID:12419228, PMID:21183956, PRO:HJD, UniProtKB:Q91ZX6]

Yes

organism-gene



PR:Q9EQE1

sentrin-specific protease 2 (rat)

rSENP2


"A sentrin-specific protease 2 that is encoded in the genome of rat." [OMA:Q9EQE1, PRO:DNx]


organism-gene



PR:Q9HC62

sentrin-specific protease 2 (human)

hSENP2


"A sentrin-specific protease 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HC62]


organism-sequence



PR:Q9HC62-1

sentrin-specific protease 2 isoform h1 (human)

hSENP2/iso:h1


"A sentrin-specific protease 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HC62-1." [PRO:DNx, UniProtKB:Q9HC62]


organism-sequence



PR:Q9HC62-2

sentrin-specific protease 2 isoform h2 (human)

hSENP2/iso:h2


"A sentrin-specific protease 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HC62-2." [PRO:DNx, UniProtKB:Q9HC62]


organism-modification



PR:000080694

sentrin-specific protease 2 methylated 1 (human)

hSENP2/Me:1


"A sentrin-specific protease 2 (human) that has been methylated on the residue at the position equivalent to Cys-505 of the amino acid sequence represented by UniProtKB:Q9HC62-1. Example: UniProtKB:Q9HC62-1, Cys-505, MOD:00660." [IEDB_epitope:1041811, PRO:DNx]


organism-modification



PR:000085422

sentrin-specific protease 2 cysteinylated 1 (human)

hSENP2/Cyst:1


"A sentrin-specific protease 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-505 of the amino acid sequence represented by UniProtKB:Q9HC62-1. Example: UniProtKB:Q9HC62-1, Cys-505, MOD:00765." [IEDB_epitope:1041810, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q91ZX6-1 mSENP2/iso:1 acts_upstream_of_or_withinGO:0016926 protein desumoylation MGI_ref:5433829; PMID:21183956
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator MGI_ref:5433829; PMID:21183956
GO:1901797 negative regulation of signal transduction by p53 class mediator MGI_ref:5433829; PMID:21183956
enablesGO:0016929 deSUMOylase activity MGI_ref:5433829; PMID:21183956
located_inGO:0005634 nucleus MGI_ref:5433829; PMID:21183956
PR:Q91ZX6-2 mSENP2/iso:2 located_inGO:0031410 cytoplasmic vesicle MGI_ref:5433829; PMID:21183956
PR:Q91ZX6-3 mSENP2/iso:3 located_inGO:0005737 cytoplasm MGI_ref:5433829; PMID:21183956