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Protein Ontology report - solute carrier family 12 member 1
PR:000014924 - http://purl.obolibrary.org/obo/PR_000014924
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000014924   
  PRO namesolute carrier family 12 member 1 
  Synonyms
PRO-Short-label: EXACT:SLC12A1
Gene-based: RELATED:NKCC2
Other: EXACT:BSC1 | bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 | kidney-specific Na-K-Cl symporter | Na-K-2Cl cotransporter 2
  Definition"A protein that is a translation product of the human SLC12A1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:968
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000014924 solute carrier family 12 member 1
SLC12A1

organism-gene


PR:P55014 solute carrier family 12 member 1 (mouse)
mSLC12A1

organism-sequence


PR:P55014-1 solute carrier family 12 member 1 isoform A (mouse)
mSlc12a1/iso:A
Yes
organism-sequence


PR:P55014-2 solute carrier family 12 member 1 isoform A4 (mouse)
mSlc12a1/iso:A4

organism-sequence


PR:P55014-3 solute carrier family 12 member 1 isoform B (mouse)
mSlc12a1/iso:B

organism-sequence


PR:P55014-4 solute carrier family 12 member 1 isoform F (mouse)
mSlc12a1/iso:F
Yes
organism-gene


PR:P55016 solute carrier family 12 member 1 (rat)
rSLC12A1

organism-gene


PR:Q13621 solute carrier family 12 member 1 (human)
hSLC12A1

organism-sequence


PR:000061002 solute carrier family 12 member 1 sequence variant G319R (human)
hSLC12A1/var:G319R

organism-sequence


PR:000062019 solute carrier family 12 member 1 sequence variant R302Q (human)
hSLC12A1/var:R302Q

organism-sequence


PR:000062587 solute carrier family 12 member 1 sequence variant G278F (human)
hSLC12A1/var:G278F

organism-sequence


PR:000064376 solute carrier family 12 member 1 sequence variant D648N (human)
hSLC12A1/var:D648N

organism-sequence


PR:Q13621-1 solute carrier family 12 member 1 isoform A (human)
hSLC12A1/iso:A

organism-sequence


PR:Q13621-2 solute carrier family 12 member 1 isoform B (human)
hSLC12A1/iso:B

organism-sequence


PR:Q13621-3 solute carrier family 12 member 1 isoform F (human)
hSLC12A1/iso:F

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0070886 positive regulation of calcineurin-NFAT signaling cascadePR:P55014-1 mSlc12a1/iso:A MGI_ref:4947009; PMID:21228109
GO:0071475 cellular hyperosmotic salinity responsePR:P55014-1 mSlc12a1/iso:A MGI_ref:4947009; PMID:21228109

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005515 protein bindingPR:P55014-4 mSlc12a1/iso:F MGI_ref:5538439; PMID:24133122
GO:0008511 sodium:potassium:chloride symporter activityPR:P55014-4 mSlc12a1/iso:F MGI_ref:5538439; PMID:24133122