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Protein Ontology report - serine/threonine-protein kinase STK11
PR:000015740 - http://purl.obolibrary.org/obo/PR_000015740
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000015740   
  PRO nameserine/threonine-protein kinase STK11 
  Synonyms
PRO-Short-label: EXACT:STK11
Gene-based: RELATED:LKB1 | PJS
Other: EXACT:renal carcinoma antigen NY-REN-19 | serine/threonine-protein kinase LKB1
  Definition"A protein that is a translation product of the human STK11 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 8                                        
         Sequence2                                                  Organism-Sequence 10                                        
         Modification3                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2212
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000015740 serine/threonine-protein kinase STK11
STK11

organism-gene


PR:D4AE59 serine/threonine-protein kinase STK11 (rat)
rSTK11

organism-sequence


PR:D4AE59-1 serine/threonine-protein kinase STK11 isoform r1 (rat)
rSTK11/iso:r1

organism-sequence


PR:D4AE59-2 serine/threonine-protein kinase STK11 isoform r2 (rat)
rSTK11/iso:r2

organism-gene


PR:Q0GGW5 serine/threonine-protein kinase STK11 (chicken)
chick-STK11

organism-gene


PR:Q15831 serine/threonine-protein kinase STK11 (human)
hSTK11

organism-sequence


PR:Q15831-1 serine/threonine-protein kinase STK11 isoform 1 (human)
hSTK11/iso:1

organism-sequence


PR:Q15831-2 serine/threonine-protein kinase STK11 isoform 2 (human)
hSTK11/iso:2

organism-modification


PR:000045948 serine/threonine-protein kinase STK11 phosphorylated 1 (human)
hSTK11/Phos:1

organism-modification


PR:000079829 serine/threonine-protein kinase STK11, mature form (human)
hSTK11/mature

organism-gene


PR:Q54WJ0 serine/threonine-protein kinase stk11 homolog (Dictyostelium discoideum)
Dicty-STK11

organism-gene


PR:Q8T9L5 GM01569p (fruit fly)
fly-STK11

organism-gene


PR:Q9GN62 serine/threonine-protein kinase par-4 (worm)
STK11 (worm)

organism-sequence


PR:Q9GN62-1 serine/threonine-protein kinase par-4 isoform a (worm)
STK11/iso:a (worm)

organism-sequence


PR:Q9GN62-2 serine/threonine-protein kinase par-4 isoform b (worm)
STK11/iso:b (worm)

organism-sequence


PR:Q9GN62-3 serine/threonine-protein kinase par-4 isoform c (worm)
STK11/iso:c (worm)

organism-gene


PR:Q9UU87 serine/threonine-protein kinase ppk34 (Schizosaccharomyces pombe 972h-)
Spom972h-STK11

organism-gene


PR:Q9WTK7 serine/threonine-protein kinase STK11 (mouse)
mSTK11

organism-sequence


PR:Q9WTK7-1 serine/threonine-protein kinase STK11 isoform 1 (mouse)
mSTK11/iso:1
Yes
Yes
organism-modification


PR:000036893 serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse)
mSTK11/iso:1/Phos:1
Yes
organism-modification


PR:000036995 serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse)
mSTK11/iso:1/Phos:2
Yes
organism-modification


PR:000036997 serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse)
mSTK11/iso:1/UnPhos:1
Yes
organism-modification


PR:000045394 serine/threonine-protein kinase STK11 isoform 1 farnesylated 1 (mouse)
mSTK11/iso:1/Farn:1

organism-modification


PR:000045395 serine/threonine-protein kinase STK11 isoform 1 farnesylated and phosphorylated 1 (mouse)
mSTK11/iso:1/FarnPhos:1

organism-sequence


PR:Q9WTK7-2 serine/threonine-protein kinase STK11 isoform 2 (mouse)
mSTK11/iso:2
Yes
Yes
organism-sequence


PR:Q9WTK7-3 serine/threonine-protein kinase STK11 isoform m3 (mouse)
mSTK11/iso:m3

sequence


PR:000036874 serine/threonine-protein kinase STK11 isoform 1
STK11/iso:1

organism-sequence


PR:Q15831-1 serine/threonine-protein kinase STK11 isoform 1 (human)
hSTK11/iso:1

organism-sequence


PR:Q9WTK7-1 serine/threonine-protein kinase STK11 isoform 1 (mouse)
mSTK11/iso:1
Yes
Yes
organism-modification


PR:000036893 serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse)
mSTK11/iso:1/Phos:1
Yes
organism-modification


PR:000036995 serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse)
mSTK11/iso:1/Phos:2
Yes
organism-modification


PR:000036997 serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse)
mSTK11/iso:1/UnPhos:1
Yes
organism-modification


PR:000045394 serine/threonine-protein kinase STK11 isoform 1 farnesylated 1 (mouse)
mSTK11/iso:1/Farn:1

organism-modification


PR:000045395 serine/threonine-protein kinase STK11 isoform 1 farnesylated and phosphorylated 1 (mouse)
mSTK11/iso:1/FarnPhos:1

modification


PR:000036892 serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1
STK11/iso:1/Phos:1

organism-modification


PR:000036893 serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse)
mSTK11/iso:1/Phos:1
Yes
modification


PR:000036994 serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2
STK11/iso:1/Phos:2
Yes
organism-modification


PR:000036995 serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse)
mSTK11/iso:1/Phos:2
Yes
modification


PR:000036996 serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1
STK11/iso:1/UnPhos:1

organism-modification


PR:000036997 serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse)
mSTK11/iso:1/UnPhos:1
Yes
sequence


PR:000036876 serine/threonine-protein kinase STK11 isoform 2
STK11/iso:2

organism-sequence


PR:Q15831-2 serine/threonine-protein kinase STK11 isoform 2 (human)
hSTK11/iso:2

organism-sequence


PR:Q9WTK7-2 serine/threonine-protein kinase STK11 isoform 2 (mouse)
mSTK11/iso:2
Yes
Yes
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STK11 forms found in complexes   

STK11 Component
 Complexes
PR:Q9WTK7ZDASHZ1 mSTK11/iso:1 PR:000025037 Stk11 isoform 1:Strada:Cab39 heterotrimer (mouse)
PR:Q9WTK7ZDASHZ2 mSTK11/iso:2 PR:000025038 Stk11 isoform 2:Strada:Cab39 heterotrimer (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036893 mSTK11/iso:1/Phos:1
UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048		 located_inGO:0005634 nucleus MGI_ref:4439241; PMID:20142099
PR:000036994 STK11/iso:1/Phos:2
Example: UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048		 acts_upstream_of_or_withinGO:0036399 TCR signalosome assembly MGI_ref:5003385; PMID:21487392
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI_ref:5003385; PMID:21487392
located_inGO:0036398 TCR signalosome MGI_ref:5003385; PMID:21487392
PR:000036995 mSTK11/iso:1/Phos:2
UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048		 acts_upstream_of_or_withinGO:0036399 TCR signalosome assembly MGI_ref:5003385; PMID:21487392
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI_ref:5003385; PMID:21487392
located_inGO:0036398 TCR signalosome MGI_ref:5003385; PMID:21487392
PR:000036997 mSTK11/iso:1/UnPhos:1
UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291		 located_inGO:0005737 cytoplasm MGI_ref:4439241; PMID:20142099
PR:Q9WTK7-1 mSTK11/iso:1
This isoform is widely expressed		 acts_upstream_of_or_withinGO:0032147 activation of protein kinase activity MGI_ref:3836081; PMID:18854309
located_inGO:0005737 cytoplasm MGI_ref:3836081; PMID:18854309
GO:0016020 membrane MGI_ref:3836081; PMID:18854309
PR:Q9WTK7-2 mSTK11/iso:2
This isoform has predominant expression in the testis		 located_inGO:0005737 cytoplasm MGI_ref:3836081; PMID:18854309