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Protein Ontology report - serine/threonine-protein kinase STK11
PR:000015740 - http://purl.obolibrary.org/obo/PR_000015740
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000015740   
  PRO nameserine/threonine-protein kinase STK11 
  Synonyms
PRO-Short-label: EXACT:STK11
Gene-based: RELATED:LKB1 | PJS
Other: EXACT:renal carcinoma antigen NY-REN-19 | serine/threonine-protein kinase LKB1
  Definition"A protein that is a translation product of the human STK11 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 8                                        
         Sequence2                                                  Organism-Sequence 10                                        
         Modification3                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2212
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000015740
serine/threonine-protein kinase STK11
STK11
"A protein that is a translation product of the human STK11 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:D4AE59
serine/threonine-protein kinase STK11 (rat)
rSTK11
"A serine/threonine-protein kinase STK11 that is encoded in the genome of rat." [OMA:D4AE59, PRO:DNx]

organism-sequence


PR:D4AE59-1
serine/threonine-protein kinase STK11 isoform r1 (rat)
rSTK11/iso:r1
"A serine/threonine-protein kinase STK11 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:D4AE59-1." [PRO:DNx, UniProtKB:D4AE59]

organism-sequence


PR:D4AE59-2
serine/threonine-protein kinase STK11 isoform r2 (rat)
rSTK11/iso:r2
"A serine/threonine-protein kinase STK11 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:D4AE59-2." [PRO:DNx, UniProtKB:D4AE59]

organism-gene


PR:Q0GGW5
serine/threonine-protein kinase STK11 (chicken)
chick-STK11
"A serine/threonine-protein kinase STK11 that is encoded in the genome of chicken." [OMA:Q0GGW5, PRO:DNx]

organism-gene


PR:Q15831
serine/threonine-protein kinase STK11 (human)
hSTK11
"A serine/threonine-protein kinase STK11 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15831]

organism-sequence


PR:Q15831-1
serine/threonine-protein kinase STK11 isoform 1 (human)
hSTK11/iso:1
"A serine/threonine-protein kinase STK11 isoform 1 that is encoded in the genome of human." [PMID:18854309, PRO:CNA]

organism-sequence


PR:Q15831-2
serine/threonine-protein kinase STK11 isoform 2 (human)
hSTK11/iso:2
"A serine/threonine-protein kinase STK11 isoform 2 that is encoded in the genome of human." [PMID:15489334, PMID:18854309, PRO:CNA]

organism-modification


PR:000045948
serine/threonine-protein kinase STK11 phosphorylated 1 (human)
hSTK11/Phos:1
"A serine/threonine-protein kinase STK11 (human) that has been phosphorylated on the residue at the position equivalent to Ser-428 of the amino acid sequence represented by UniProtKB:Q15831-1. Example: UniProtKB:Q15831-1, Ser-428, MOD:00046." [iPTMnet:Q15831, PMID:18321849]

organism-modification


PR:000079829
serine/threonine-protein kinase STK11, mature form (human)
hSTK11/mature
"A serine/threonine-protein kinase STK11 (human) that has had the propeptide removed. Example: UniProtKB:Q15831-1, 1-430." [PRO:DNx, Reactome:R-HSA-164119]

organism-gene


PR:Q54WJ0
serine/threonine-protein kinase stk11 homolog (Dictyostelium discoideum)
Dicty-STK11
"A serine/threonine-protein kinase STK11 that is encoded in the genome of Dictyostelium discoideum." [PRO:DNx]

organism-gene


PR:Q8T9L5
GM01569p (fruit fly)
fly-STK11
"A serine/threonine-protein kinase STK11 that is encoded in the genome of fruit fly." [PRO:DNx]

organism-gene


PR:Q9GN62
serine/threonine-protein kinase par-4 (worm)
STK11 (worm)
"A serine/threonine-protein kinase STK11 that is encoded in the genome of worm." [PRO:DNx]

organism-sequence


PR:Q9GN62-1
serine/threonine-protein kinase par-4 isoform a (worm)
STK11/iso:a (worm)
"A serine/threonine-protein kinase par-4 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9GN62-1." [PRO:DNx, UniProtKB:Q9GN62]

organism-sequence


PR:Q9GN62-2
serine/threonine-protein kinase par-4 isoform b (worm)
STK11/iso:b (worm)
"A serine/threonine-protein kinase par-4 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9GN62-2." [PRO:DNx, UniProtKB:Q9GN62]

organism-sequence


PR:Q9GN62-3
serine/threonine-protein kinase par-4 isoform c (worm)
STK11/iso:c (worm)
"A serine/threonine-protein kinase par-4 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9GN62-3." [PRO:DNx, UniProtKB:Q9GN62]

organism-gene


PR:Q9UU87
serine/threonine-protein kinase ppk34 (Schizosaccharomyces pombe 972h-)
Spom972h-STK11
"A serine/threonine-protein kinase STK11 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:DNx]

organism-gene


PR:Q9WTK7
serine/threonine-protein kinase STK11 (mouse)
mSTK11
"A serine/threonine-protein kinase STK11 that is encoded in the genome of mouse." [OMA:Q9WTK7, PRO:DNx]

organism-sequence


PR:Q9WTK7-1
serine/threonine-protein kinase STK11 isoform 1 (mouse)
mSTK11/iso:1
"A serine/threonine-protein kinase STK11 isoform 1 that is encoded in the genome of mouse. This isoform includes the sequence encoded by exon IXa. This isoform is widely expressed." [PRO:KRC]
Yes
Yes
organism-modification


PR:000036893
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse)
mSTK11/iso:1/Phos:1
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048." [PMID:18854309, PMID:20142099, PRO:KRC]
Yes
organism-modification


PR:000036995
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse)
mSTK11/iso:1/Phos:2
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048." [PMID:21487392, PRO:KRC]
Yes
organism-modification


PR:000036997
serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse)
mSTK11/iso:1/UnPhos:1
"A serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291." [PMID:18854309, PMID:20142099, PRO:KRC]
Yes
organism-modification


PR:000045394
serine/threonine-protein kinase STK11 isoform 1 farnesylated 1 (mouse)
mSTK11/iso:1/Farn:1
"A serine/threonine-protein kinase STK11 isoform 1 (mouse) that has a farnesyl moiety on a Cys residue in the most C-terminal Cys. UniProtKB:Q9WTK7-1, Cys-433, MOD:00111." [PMID:24295069, PRO:KRC]

organism-modification


PR:000045395
serine/threonine-protein kinase STK11 isoform 1 farnesylated and phosphorylated 1 (mouse)
mSTK11/iso:1/FarnPhos:1
"A serine/threonine-protein kinase STK11 isoform 1 (mouse) that is phosphorylated on Ser-431 and has a farnesyl moiety on a Cys residue in the most C-terminal Cys. UniProtKB:Q9WTK7-1, Ser-431, MOD:00046|Cys-433, MOD:00111." [PMID:24295069, PRO:KRC]

organism-sequence


PR:Q9WTK7-2
serine/threonine-protein kinase STK11 isoform 2 (mouse)
mSTK11/iso:2
"A serine/threonine-protein kinase STK11 isoform 2 that is encoded in the genome of mouse. This isoform is shorter than isoform 1 at the C-terminal region due to usage of exon IXb. This isoform has predominant expression in the testis." [PMID:18854309, PRO:KRC]
Yes
Yes
organism-sequence


PR:Q9WTK7-3
serine/threonine-protein kinase STK11 isoform m3 (mouse)
mSTK11/iso:m3
"A serine/threonine-protein kinase STK11 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WTK7-3." [PRO:DNx, UniProtKB:Q9WTK7]

sequence


PR:000036874
serine/threonine-protein kinase STK11 isoform 1
STK11/iso:1
"A serine/threonine-protein kinase STK11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WTK7-1 or a 1:1 ortholog thereof." [PMID:18854309, PRO:KRC]

organism-sequence


PR:Q15831-1
serine/threonine-protein kinase STK11 isoform 1 (human)
hSTK11/iso:1
"A serine/threonine-protein kinase STK11 isoform 1 that is encoded in the genome of human." [PMID:18854309, PRO:CNA]

organism-sequence


PR:Q9WTK7-1
serine/threonine-protein kinase STK11 isoform 1 (mouse)
mSTK11/iso:1
"A serine/threonine-protein kinase STK11 isoform 1 that is encoded in the genome of mouse. This isoform includes the sequence encoded by exon IXa. This isoform is widely expressed." [PRO:KRC]
Yes
Yes
organism-modification


PR:000036893
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse)
mSTK11/iso:1/Phos:1
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048." [PMID:18854309, PMID:20142099, PRO:KRC]
Yes
organism-modification


PR:000036995
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse)
mSTK11/iso:1/Phos:2
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048." [PMID:21487392, PRO:KRC]
Yes
organism-modification


PR:000036997
serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse)
mSTK11/iso:1/UnPhos:1
"A serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291." [PMID:18854309, PMID:20142099, PRO:KRC]
Yes
organism-modification


PR:000045394
serine/threonine-protein kinase STK11 isoform 1 farnesylated 1 (mouse)
mSTK11/iso:1/Farn:1
"A serine/threonine-protein kinase STK11 isoform 1 (mouse) that has a farnesyl moiety on a Cys residue in the most C-terminal Cys. UniProtKB:Q9WTK7-1, Cys-433, MOD:00111." [PMID:24295069, PRO:KRC]

organism-modification


PR:000045395
serine/threonine-protein kinase STK11 isoform 1 farnesylated and phosphorylated 1 (mouse)
mSTK11/iso:1/FarnPhos:1
"A serine/threonine-protein kinase STK11 isoform 1 (mouse) that is phosphorylated on Ser-431 and has a farnesyl moiety on a Cys residue in the most C-terminal Cys. UniProtKB:Q9WTK7-1, Ser-431, MOD:00046|Cys-433, MOD:00111." [PMID:24295069, PRO:KRC]

modification


PR:000036892
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1
STK11/iso:1/Phos:1
"A serine/threonine-protein kinase STK11 isoform 1 that has been phosphorylated on two Tyr residues. Example: UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048." [PMID:18854309, PMID:20142099, PRO:KRC]

organism-modification


PR:000036893
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse)
mSTK11/iso:1/Phos:1
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048." [PMID:18854309, PMID:20142099, PRO:KRC]
Yes
modification


PR:000036994
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2
STK11/iso:1/Phos:2
"A serine/threonine-protein kinase STK11 isoform 1 that has been phosphorylated on three Tyr residues. Example: UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048." [PMID:21487392, PRO:KRC]
Yes
organism-modification


PR:000036995
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse)
mSTK11/iso:1/Phos:2
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048." [PMID:21487392, PRO:KRC]
Yes
modification


PR:000036996
serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1
STK11/iso:1/UnPhos:1
"A serine/threonine-protein kinase STK11 isoform 1 that lacks phosphorylation at residues equivalent to Tyr-261 and Tyr-365 of the amino acid sequence represented by UniProtKB:Q9WTK7-1. Example: UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291." [PMID:18854309, PMID:20142099, PRO:KRC]

organism-modification


PR:000036997
serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse)
mSTK11/iso:1/UnPhos:1
"A serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291." [PMID:18854309, PMID:20142099, PRO:KRC]
Yes
sequence


PR:000036876
serine/threonine-protein kinase STK11 isoform 2
STK11/iso:2
"A serine/threonine-protein kinase STK11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WTK7-2 or a 1:1 ortholog thereof. Alternative splicing of the STK11 gene after exon VIII leads to its distinct shorter C-terminal amino acid sequence." [PMID:18854309, PRO:KRC]

organism-sequence


PR:Q15831-2
serine/threonine-protein kinase STK11 isoform 2 (human)
hSTK11/iso:2
"A serine/threonine-protein kinase STK11 isoform 2 that is encoded in the genome of human." [PMID:15489334, PMID:18854309, PRO:CNA]

organism-sequence


PR:Q9WTK7-2
serine/threonine-protein kinase STK11 isoform 2 (mouse)
mSTK11/iso:2
"A serine/threonine-protein kinase STK11 isoform 2 that is encoded in the genome of mouse. This isoform is shorter than isoform 1 at the C-terminal region due to usage of exon IXb. This isoform has predominant expression in the testis." [PMID:18854309, PRO:KRC]
Yes
Yes
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STK11 forms found in complexes   

STK11 Component
 Complexes
PR:Q9WTK7ZDASHZ1 mSTK11/iso:1 PR:000025037 Stk11 isoform 1:Strada:Cab39 heterotrimer (mouse)
PR:Q9WTK7ZDASHZ2 mSTK11/iso:2 PR:000025038 Stk11 isoform 2:Strada:Cab39 heterotrimer (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036893 mSTK11/iso:1/Phos:1
UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048		 located_inGO:0005634 nucleus MGI_ref:4439241; PMID:20142099
PR:000036994 STK11/iso:1/Phos:2
Example: UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048		 acts_upstream_of_or_withinGO:0036399 TCR signalosome assembly MGI_ref:5003385; PMID:21487392
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI_ref:5003385; PMID:21487392
located_inGO:0036398 TCR signalosome MGI_ref:5003385; PMID:21487392
PR:000036995 mSTK11/iso:1/Phos:2
UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048		 acts_upstream_of_or_withinGO:0036399 TCR signalosome assembly MGI_ref:5003385; PMID:21487392
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI_ref:5003385; PMID:21487392
located_inGO:0036398 TCR signalosome MGI_ref:5003385; PMID:21487392
PR:000036997 mSTK11/iso:1/UnPhos:1
UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291		 located_inGO:0005737 cytoplasm MGI_ref:4439241; PMID:20142099
PR:Q9WTK7-1 mSTK11/iso:1
This isoform is widely expressed		 acts_upstream_of_or_withinGO:0032147 activation of protein kinase activity MGI_ref:3836081; PMID:18854309
located_inGO:0005737 cytoplasm MGI_ref:3836081; PMID:18854309
GO:0016020 membrane MGI_ref:3836081; PMID:18854309
PR:Q9WTK7-2 mSTK11/iso:2
This isoform has predominant expression in the testis		 located_inGO:0005737 cytoplasm MGI_ref:3836081; PMID:18854309