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Protein Ontology report - DNA topoisomerase 2-alpha
PR:000016544 - http://purl.obolibrary.org/obo/PR_000016544
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000016544   
  PRO nameDNA topoisomerase 2-alpha 
  Synonyms
PRO-Short-label: EXACT:TOP2A
Gene-based: RELATED:Top-2 | TOP2
Other: EXACT:DNA topoisomerase II, alpha isozyme
  Definition"A protein that is a translation product of the human TOP2A gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2637
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000016544

DNA topoisomerase 2-alpha

TOP2A


"A protein that is a translation product of the human TOP2A gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O42130

DNA topoisomerase 2-alpha (chicken)

chick-TOP2A


"A DNA topoisomerase 2-alpha that is encoded in the genome of chicken." [OMA:O42130, PRO:DNx]


organism-gene



PR:P11388

DNA topoisomerase 2-alpha (human)

hTOP2A


"A DNA topoisomerase 2-alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11388]


organism-sequence



PR:P11388-1

DNA topoisomerase 2-alpha isoform h1 (human)

hTOP2A/iso:h1


"A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-1." [PRO:DNx, UniProtKB:P11388]


organism-sequence



PR:P11388-2

DNA topoisomerase 2-alpha isoform h2 (human)

hTOP2A/iso:h2


"A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-2." [PRO:DNx, UniProtKB:P11388]


organism-sequence



PR:P11388-3

DNA topoisomerase 2-alpha isoform h3 (human)

hTOP2A/iso:h3


"A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-3." [PRO:DNx, UniProtKB:P11388]


organism-sequence



PR:P11388-4

DNA topoisomerase 2-alpha isoform h4 (human)

hTOP2A/iso:h4


"A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-4." [PRO:DNx, UniProtKB:P11388]


organism-modification



PR:000064765

DNA topoisomerase 2-alpha sumoylated form (human)

hTOP2A/SumoLys+


"A DNA topoisomerase 2-alpha (human) that includes at least one sumoylated lysine. UniProtKB:P11388, MOD:01149." [PRO:DNx, Reactome:R-HSA-4641298, Reactome:R-HSA-4641367]


organism-modification



PR:000065564

DNA topoisomerase 2-alpha deaminated 1 (human)

hTOP2A/Deam:1


"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Gln-746 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Gln-746, MOD:00685." [IEDB_epitope:1584152, PRO:DNx]


organism-modification



PR:000067662

DNA topoisomerase 2-alpha deaminated 2 (human)

hTOP2A/Deam:2


"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-782 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Asn-782, MOD:00684." [IEDB_epitope:1582064, PRO:DNx]


organism-modification



PR:000069448

DNA topoisomerase 2-alpha cysteinylated 1 (human)

hTOP2A/Cyst:1


"A DNA topoisomerase 2-alpha (human) that has been cysteinylated on the residue at the position equivalent to Cys-1008 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Cys-1008, MOD:00765." [IEDB_epitope:638451, PRO:DNx]


organism-modification



PR:000071344

DNA topoisomerase 2-alpha deaminated 3 (human)

hTOP2A/Deam:3


"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-294 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Asn-294, MOD:00684." [IEDB_epitope:928312, PRO:DNx]


organism-modification



PR:000072972

DNA topoisomerase 2-alpha phosphorylated 1 (human)

hTOP2A/Phos:1


"A DNA topoisomerase 2-alpha (human) that has been phosphorylated on the residue at the position equivalent to Ser-29 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Ser-29, MOD:00046." [IEDB_epitope:1360062, IEDB_epitope:927919, PRO:DNx]


organism-modification



PR:000076890

DNA topoisomerase 2-alpha phosphorylated 2 (human)

hTOP2A/Phos:2


"A DNA topoisomerase 2-alpha (human) that has been phosphorylated on the residue at the position equivalent to Ser-30 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Ser-30, MOD:00046." [IEDB_epitope:609594, PRO:DNx]


organism-modification



PR:000077986

DNA topoisomerase 2-alpha deaminated 4 (human)

hTOP2A/Deam:4


"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-345 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Asn-345, MOD:00684." [IEDB_epitope:996633, PRO:DNx]


organism-modification



PR:000080098

DNA topoisomerase 2-alpha deaminated 5 (human)

hTOP2A/Deam:5


"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-833 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Asn-833, MOD:00684." [IEDB_epitope:1353270, PRO:DNx]


organism-modification



PR:000080516

DNA topoisomerase 2-alpha cysteinylated 2 (human)

hTOP2A/Cyst:2


"A DNA topoisomerase 2-alpha (human) that has been cysteinylated on the residue at the position equivalent to Cys-170 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Cys-170, MOD:00765." [IEDB_epitope:1024632, PRO:DNx]


organism-modification



PR:000080620

DNA topoisomerase 2-alpha methylated 1 (human)

hTOP2A/Me:1


"A DNA topoisomerase 2-alpha (human) that has been methylated on the residue at the position equivalent to Cys-1008 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Cys-1008, MOD:00660." [IEDB_epitope:1029127, IEDB_epitope:1058044, PRO:DNx]


organism-modification



PR:000084338

DNA topoisomerase 2-alpha deaminated 6 (human)

hTOP2A/Deam:6


"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-917 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Asn-917, MOD:00684." [IEDB_epitope:1341909, PRO:DNx]


organism-modification



PR:000085682

DNA topoisomerase 2-alpha methylated 2 (human)

hTOP2A/Me:2


"A DNA topoisomerase 2-alpha (human) that has been methylated on the residue at the position equivalent to Cys-300 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Cys-300, MOD:00660." [IEDB_epitope:1019210, PRO:DNx]


organism-gene



PR:P41516

DNA topoisomerase 2-alpha (rat)

rTOP2A


"A DNA topoisomerase 2-alpha that is encoded in the genome of rat." [OMA:P41516, PRO:DNx]


organism-gene



PR:Q01320

DNA topoisomerase 2-alpha (mouse)

mTOP2A


"A DNA topoisomerase 2-alpha that is encoded in the genome of mouse." [OMA:Q01320, PRO:DNx]