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modification
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PR:000021971 |
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
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IRAK1/iso:1/PhosRes+
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"An interleukin-1 receptor-associated kinase 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
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modification
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PR:000021975 |
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
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IRAK1/iso:1/Phos:1
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"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located at the N terminus of the kinase domain. This is the first step following the activation of the TLR/IL-1 receptor complex. This phosphorylation results in a conformational change of the kinase domain. Example: UniProtKB:P51617-1, Thr-209, MOD:00047." [PMID:11960013, PMID:14625308, PRO:CNA, TLR:AMM]
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organism-modification
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PR:000027178 |
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)
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mIRAK1/iso:1/Phos:1
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"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q62406-1, Thr-209, MOD:00047." [PMID:12538665, TLR:AMM]
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Yes |
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organism-modification
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PR:000027494 |
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
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hIRAK1/iso:1/Phos:1
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"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P51617-1, Thr-209, MOD:00047." [PRO:DNx, UniProtKB:P51617]
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Yes |
Yes |
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modification
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PR:000021977 |
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3
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IRAK1/iso:1/Phos:3
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"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located near the N terminus of the kinase domain, and on a Thr residue located in the activation loop (Thr-387 in human). The latter phosphorylation is the second step following the activation of the TLR/IL-1 receptor complex. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA, PRO:DAN]
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organism-modification
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PR:000027492 |
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)
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hIRAK1/iso:1/Phos:3
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"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA]
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Yes |
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modification
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PR:000021978 |
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4
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IRAK1/iso:1/Phos:4
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"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation occurs by interleukin-1 receptor-associated kinase 4 (IRAK-4) and extensively autophosphorylated in the Pro-, Ser-, and Thr-rich ProST region between the N-terminal death domain and kinase domain. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046." [PMID:14625308, PRO:CNA, PRO:DAN]
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organism-modification
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PR:000027493 |
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)
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hIRAK1/iso:1/Phos:4
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"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046." [PMID:14625308, PRO:CNA]
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Yes |
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organism-modification
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PR:000061935 |
interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)
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hIRAK1/iso:1/pSerThr+
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"An interleukin-1 receptor-associated kinase 1 isoform 1 (human) that includes at least one phosphorylated serine and at least one phosphorylated threonine. UniProtKB:P51617-1, MOD:00046|MOD:00047." [PRO:DNx, Reactome:R-HSA-193904]
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