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Protein Ontology report - interleukin-1 receptor-associated kinase 1 isoform 1
PR:000021973 - http://purl.obolibrary.org/obo/PR_000021973
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000021973   
  PRO nameinterleukin-1 receptor-associated kinase 1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:IRAK1/iso:1
  Definition"An interleukin-1 receptor-associated kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-1 or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000001782 interleukin-1 receptor-associated kinase 1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000021973 interleukin-1 receptor-associated kinase 1 isoform 1
IRAK1/iso:1

organism-sequence


PR:P51617-1 interleukin-1 receptor-associated kinase 1 isoform 1 (human)
hIRAK1/iso:1
Yes
organism-modification


PR:000027492 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)
hIRAK1/iso:1/Phos:3
Yes
organism-modification


PR:000027493 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)
hIRAK1/iso:1/Phos:4
Yes
organism-modification


PR:000027494 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
hIRAK1/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000061935 interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)
hIRAK1/iso:1/pSerThr+

organism-sequence


PR:Q62406-1 interleukin-1 receptor-associated kinase 1 isoform 1 (mouse)
mIRAK1/iso:1

organism-modification


PR:000027178 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)
mIRAK1/iso:1/Phos:1

Yes
organism-modification


PR:000027179 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)
mIRAK1/iso:1/UnMod

Yes
modification


PR:000021971 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
IRAK1/iso:1/PhosRes+

modification


PR:000021975 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
IRAK1/iso:1/Phos:1

organism-modification


PR:000027178 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)
mIRAK1/iso:1/Phos:1

Yes
organism-modification


PR:000027494 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
hIRAK1/iso:1/Phos:1
Yes
Yes
modification


PR:000021977 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3
IRAK1/iso:1/Phos:3

organism-modification


PR:000027492 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)
hIRAK1/iso:1/Phos:3
Yes
modification


PR:000021978 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4
IRAK1/iso:1/Phos:4

organism-modification


PR:000027493 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)
hIRAK1/iso:1/Phos:4
Yes
organism-modification


PR:000061935 interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)
hIRAK1/iso:1/pSerThr+

modification


PR:000021974 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form
IRAK1/iso:1/UnMod

organism-modification


PR:000027179 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)
mIRAK1/iso:1/UnMod

Yes
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IRAK1/iso:1 forms found in complexes   

IRAK1/iso:1 Component
 Complexes
PR:000027178 mIRAK1/iso:1/Phos:1 PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027179 mIRAK1/iso:1/UnMod PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027253 IRAK1:tollip complex (mouse)
PR:000027494 hIRAK1/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027492 hIRAK1/iso:1/Phos:3
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047		 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308
PR:000027493 hIRAK1/iso:1/Phos:4
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046		 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308
NOT GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
NOT GO:0005515 protein binding PMID:14625308
PR:000027494 hIRAK1/iso:1/Phos:1
UniProtKB:P51617-1, Thr-209, MOD:00047		 enablesGO:0005515 protein binding with PR:Q9NWZ3 hIRAK4 PMID:11960013
GO:0016301 kinase activity PMID:11960013
PR:P51617-1 hIRAK1/iso:1 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
GO:0005515 protein binding with PR:Q9Y4K3 E3 ubiquitin-protein ligase TRAF6 (human) PMID:14625308