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Protein Ontology report - interleukin-1 receptor-associated kinase 1 isoform 1

PR:000021973 - http://purl.obolibrary.org/obo/PR_000021973

Protein Forms

Complex

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000021973

PRO name

interleukin-1 receptor-associated kinase 1 isoform 1

Synonyms

PRO-Short-label:

EXACT:

IRAK1/iso:1

Definition

"An interleukin-1 receptor-associated kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-1 or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

sequence

Parent

PR:000001782 interleukin-1 receptor-associated kinase 1

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Sequence	1	Organism-Sequence	2
Modification	5	Organism-Modification	6

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

sequence

PR:000021973 interleukin-1 receptor-associated kinase 1 isoform 1

IRAK1/iso:1

organism-sequence

PR:P51617-1 interleukin-1 receptor-associated kinase 1 isoform 1 (human)

hIRAK1/iso:1

Yes

organism-modification

PR:000027492 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)

hIRAK1/iso:1/Phos:3

Yes

organism-modification

PR:000027493 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)

hIRAK1/iso:1/Phos:4

Yes

organism-modification

PR:000027494 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)

hIRAK1/iso:1/Phos:1

Yes

organism-modification

PR:000061935 interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)

hIRAK1/iso:1/pSerThr+

organism-sequence

PR:Q62406-1 interleukin-1 receptor-associated kinase 1 isoform 1 (mouse)

mIRAK1/iso:1

organism-modification

PR:000027178 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)

mIRAK1/iso:1/Phos:1

Yes

organism-modification

PR:000027179 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)

mIRAK1/iso:1/UnMod

Yes

modification

PR:000021971 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form

IRAK1/iso:1/PhosRes+

modification

PR:000021975 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1

IRAK1/iso:1/Phos:1

organism-modification

PR:000027178 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)

mIRAK1/iso:1/Phos:1

Yes

organism-modification

PR:000027494 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)

hIRAK1/iso:1/Phos:1

Yes

modification

PR:000021977 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3

IRAK1/iso:1/Phos:3

organism-modification

PR:000027492 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)

hIRAK1/iso:1/Phos:3

Yes

modification

PR:000021978 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4

IRAK1/iso:1/Phos:4

organism-modification

PR:000027493 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)

hIRAK1/iso:1/Phos:4

Yes

organism-modification

PR:000061935 interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)

hIRAK1/iso:1/pSerThr+

modification

PR:000021974 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form

IRAK1/iso:1/UnMod

organism-modification

PR:000027179 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)

mIRAK1/iso:1/UnMod

Yes

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IRAK1/iso:1 forms found in complexes

IRAK1/iso:1 Component	Complexes
PR:000027178 mIRAK1/iso:1/Phos:1	PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027179 mIRAK1/iso:1/UnMod	PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027179 mIRAK1/iso:1/UnMod	PR:000027253 IRAK1:tollip complex (mouse)
PR:000027494 hIRAK1/iso:1/Phos:1	PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)

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Functional Annotation (GO-centric view)

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Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0070498 interleukin-1-mediated signaling pathway	PR:000027492 hIRAK1/iso:1/Phos:3	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:P51617-1 hIRAK1/iso:1	PMID:14625308
Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0004674 protein serine/threonine kinase activity	PR:000027492 hIRAK1/iso:1/Phos:3	PMID:14625308
GO:0004674 protein serine/threonine kinase activity	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
GO:0005515 protein binding	PR:000027494 hIRAK1/iso:1/Phos:1	PMID:11960013
	PR:P51617-1 hIRAK1/iso:1	PMID:14625308
	PR:P51617-1 hIRAK1/iso:1	PMID:14625308
NOT GO:0005515 protein binding	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
	PR:000027493 hIRAK1/iso:1/Phos:4	PMID:14625308
GO:0016301 kinase activity	PR:000027494 hIRAK1/iso:1/Phos:1	PMID:11960013