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Protein Ontology report - dual specificity mitogen-activated protein kinase kinase 3/6
PR:000021990 - http://purl.obolibrary.org/obo/PR_000021990
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000021990   
  PRO namedual specificity mitogen-activated protein kinase kinase 3/6 
  Definition"A protein that is a gene product level of the MAP2K3 or the MAP2K6 gene. Members of this class activate phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively." [PIRSF:PIRSF501132] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 6                                        
         Sequence3                                                  Organism-Sequence 8                                        
         Modification5                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF501132
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000021990 dual specificity mitogen-activated protein kinase kinase 3/6
DLEC2/iso:1/SigPep-/GlycoRes+

gene


PR:000003282 dual specificity mitogen-activated protein kinase kinase 6
MAP2K6

Yes
organism-gene


PR:P52564 dual specificity mitogen-activated protein kinase kinase 6 (human)
hMAP2K6

organism-sequence


PR:P52564-1 dual specificity mitogen-activated protein kinase kinase 6 isoform 1 (human)
hMAP2K6/iso:1

organism-sequence


PR:P52564-2 dual specificity mitogen-activated protein kinase kinase 6 isoform h2 (human)
hMAP2K6/iso:h2

organism-modification


PR:000045822 dual specificity mitogen-activated protein kinase kinase 6 phosphorylated 1 (human)
hMAP2K6/Phos:1

organism-modification


PR:000048299 dual specificity mitogen-activated protein kinase kinase 6 phosphorylated 2 (human)
hMAP2K6/Phos:2

organism-modification


PR:000068145 dual specificity mitogen-activated protein kinase kinase 6 deaminated 1 (human)
hMAP2K6/Deam:1

organism-gene


PR:P70236 dual specificity mitogen-activated protein kinase kinase 6 (mouse)
mMAP2K6

organism-sequence


PR:P70236-1 dual specificity mitogen-activated protein kinase kinase 6 isoform 1 (mouse)
mMAP2K6/iso:1

organism-gene


PR:Q9DGE0 dual specificity mitogen-activated protein kinase kinase 6 (zebrafish)
z-MAP2K6

sequence


PR:000021979 dual specificity mitogen-activated protein kinase kinase 6 isoform 1
MAP2K6/iso:1

organism-sequence


PR:P52564-1 dual specificity mitogen-activated protein kinase kinase 6 isoform 1 (human)
hMAP2K6/iso:1

organism-sequence


PR:P70236-1 dual specificity mitogen-activated protein kinase kinase 6 isoform 1 (mouse)
mMAP2K6/iso:1

modification


PR:000021980 dual specificity mitogen-activated protein kinase kinase 6 isoform 1 unmodified form
MAP2K6/iso:1/UnMod

Yes
modification


PR:000021992 dual specificity mitogen-activated protein kinase kinase 6 isoform 1 phosphorylated form
MAP2K6/iso:1/PhosRes+

Yes
modification


PR:000021981 dual specificity mitogen-activated protein kinase kinase 6 isoform 1 phosphorylated 1
MAP2K6/iso:1/Phos:1

gene


PR:000003284 dual specificity mitogen-activated protein kinase kinase 3
MAP2K3

organism-gene


PR:O09110 dual specificity mitogen-activated protein kinase kinase 3 (mouse)
mMAP2K3

organism-sequence


PR:O09110-1 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse)
mMAP2K3/iso:2

organism-modification


PR:000049826 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (mouse)
mMAP2K3/iso:2/Phos:1

organism-modification


PR:000049827 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 2 (mouse)
mMAP2K3/iso:2/Phos:2

organism-sequence


PR:O09110-2 dual specificity mitogen-activated protein kinase kinase 3 isoform 1 (mouse)
mMAP2K3/iso:1

organism-gene


PR:P46734 dual specificity mitogen-activated protein kinase kinase 3 (human)
hMAP2K3

organism-sequence


PR:P46734-1 dual specificity mitogen-activated protein kinase kinase 3 isoform 3 (human)
hMAP2K3/iso:3

organism-sequence


PR:P46734-2 dual specificity mitogen-activated protein kinase kinase 3 isoform 1 (human)
hMAP2K3/iso:1

organism-modification


PR:000036646 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (human)
hMAP2K3/iso:2/Phos:1
Yes
organism-sequence


PR:P46734-3 dual specificity mitogen-activated protein kinase kinase 3 isoform h2 (human)
hMAP2K3/iso:h2

organism-modification


PR:000048297 dual specificity mitogen-activated protein kinase kinase 3 phosphorylated 1 (human)
hMAP2K3/Phos:1

organism-modification


PR:000075054 dual specificity mitogen-activated protein kinase kinase 3 cysteinylated 1 (human)
hMAP2K3/Cyst:1

organism-gene


PR:Q5ZL06 uncharacterized protein, MAP2K3 translation product (chicken)
chick-MAP2K3

sequence


PR:000021942 dual specificity mitogen-activated protein kinase kinase 3 isoform 1
MAP2K3/iso:1

organism-sequence


PR:O09110-1 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse)
mMAP2K3/iso:2

organism-modification


PR:000049826 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (mouse)
mMAP2K3/iso:2/Phos:1

organism-modification


PR:000049827 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 2 (mouse)
mMAP2K3/iso:2/Phos:2

organism-sequence


PR:P46734-1 dual specificity mitogen-activated protein kinase kinase 3 isoform 3 (human)
hMAP2K3/iso:3

sequence


PR:000021944 dual specificity mitogen-activated protein kinase kinase 3 isoform 2
MAP2K3/iso:2

organism-sequence


PR:O09110-2 dual specificity mitogen-activated protein kinase kinase 3 isoform 1 (mouse)
mMAP2K3/iso:1

organism-sequence


PR:P46734-2 dual specificity mitogen-activated protein kinase kinase 3 isoform 1 (human)
hMAP2K3/iso:1

organism-modification


PR:000036646 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (human)
hMAP2K3/iso:2/Phos:1
Yes
modification


PR:000021991 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated form
MAP2K3/iso:2/PhosRes+

modification


PR:000021946 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1
MAP2K3/iso:2/Phos:1

organism-modification


PR:000036646 dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (human)
hMAP2K3/iso:2/Phos:1
Yes
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DLEC2/iso:1/SigPep-/GlycoRes+ forms found in complexes   

DLEC2/iso:1/SigPep-/GlycoRes+ Component
 Complexes
PR:000003282 MAP2K6 PR:000027079 TAK1 kinase-MKK6 complex
PR:000021980 MAP2K6/iso:1/UnMod PR:000027080 TAK1 kinase-MKK6 complex 1
PR:000021992 MAP2K6/iso:1/PhosRes+ PR:000027081 TAK1 kinase-MKK6 complex 2
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004708 MAP kinase kinase activityPR:000036646 hMAP2K3/iso:2/Phos:1 PMID:8622669