back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - death receptor
PR:000021999 - http://purl.obolibrary.org/obo/PR_000021999
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000021999   
  PRO namedeath receptor 
  Definition"A protein that contains multiple TNFR/NGFR cysteine-rich region (Pfam:PF00020) within the extracellular ligand-binding domain, a type I (single pass) transmembrane domain, and a cytoplasmic Death domain (Pfam:PF00531) required for intracellular signaling." [PMID:12655292
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family2                                                  Organism-Family 0                                        
         Gene5                                                  Organism-Gene 10                                        
         Sequence5                                                  Organism-Sequence 15                                        
         Modification6                                                  Organism-Modification 12                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000021999

death receptor

MAP2K4/Phos:1


"A protein that contains multiple TNFR/NGFR cysteine-rich region (Pfam:PF00020) within the extracellular ligand-binding domain, a type I (single pass) transmembrane domain, and a cytoplasmic Death domain (Pfam:PF00531) required for intracellular signaling." [PMID:12655292]


gene



PR:000001405

tumor necrosis factor receptor superfamily member 16

NGFR


"A death receptor that is a translation product of the human NGFR gene or a 1:1 ortholog thereof. This receptor contains an extracellular domain containing four repeats (about 40 residues long) with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain." [PRO:JAN, RefSeq:NP_002498]


organism-gene



PR:P07174

tumor necrosis factor receptor superfamily member 16 (rat)

rNGFR


"A tumor necrosis factor receptor superfamily member 16 that is encoded in the genome of rat." [OMA:P07174, PRO:DNx]


organism-gene



PR:P08138

tumor necrosis factor receptor superfamily member 16 (human)

hNGFR


"A tumor necrosis factor receptor superfamily member 16 that is encoded in the genome of human." [PRO:JAN, UniProtKB:P08138]


organism-sequence



PR:P08138-1

tumor necrosis factor receptor superfamily member 16 isoform h1 (human)

hNGFR/iso:h1


"A tumor necrosis factor receptor superfamily member 16 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08138-1." [PRO:DNx, UniProtKB:P08138]


organism-sequence



PR:P08138-2

tumor necrosis factor receptor superfamily member 16 isoform h2 (human)

hNGFR/iso:h2


"A tumor necrosis factor receptor superfamily member 16 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08138-2." [PRO:DNx, UniProtKB:P08138]


organism-modification



PR:000048602

tumor necrosis factor receptor superfamily member 16, signal peptide removed form (human)

hNGFR/SigPep-


"A tumor necrosis factor receptor superfamily member 16 (human) that has had the signal peptide removed. UniProtKB:P08138, 29-427." [PRO:DNx, Reactome:R-HSA-193664]


organism-modification



PR:000079370

tumor necrosis factor receptor superfamily member 16 phosphorylated 1 (human)

hNGFR/Phos:1


"A tumor necrosis factor receptor superfamily member 16 (human) that has been phosphorylated on the residue at the position equivalent to Thr-377 of the amino acid sequence represented by UniProtKB:P08138-1. Example: UniProtKB:P08138-1, Thr-377, MOD:00047." [IEDB_epitope:986644, PRO:DNx]


organism-modification



PR:000080139

tumor necrosis factor receptor superfamily member 16 cysteinylated 1 (human)

hNGFR/Cyst:1


"A tumor necrosis factor receptor superfamily member 16 (human) that has been cysteinylated on the residue at the position equivalent to Cys-67 of the amino acid sequence represented by UniProtKB:P08138-1. Example: UniProtKB:P08138-1, Cys-67, MOD:00765." [IEDB_epitope:2119734, PRO:DNx]


organism-modification



PR:000085271

tumor necrosis factor receptor superfamily member 16 cysteinylated 2 (human)

hNGFR/Cyst:2


"A tumor necrosis factor receptor superfamily member 16 (human) that has been cysteinylated on the residue at the position equivalent to Cys-138 of the amino acid sequence represented by UniProtKB:P08138-1. Example: UniProtKB:P08138-1, Cys-138, MOD:00765." [IEDB_epitope:2121303, IEDB_epitope:2127594, PRO:DNx]


organism-gene



PR:P18519

tumor necrosis factor receptor superfamily member 16 (chicken)

chick-NGFR


"A tumor necrosis factor receptor superfamily member 16 that is encoded in the genome of chicken." [OMA:P18519, PRO:DNx]


organism-gene



PR:Q9Z0W1

tumor necrosis factor receptor superfamily member 16 (mouse)

mNGFR


"A tumor necrosis factor receptor superfamily member 16 that is encoded in the genome of mouse." [OMA:Q9Z0W1, PRO:DNx]


organism-sequence



PR:Q9Z0W1-1

tumor necrosis factor receptor superfamily member 16 isoform m1 (mouse)

mNGFR/iso:m1


"A tumor necrosis factor receptor superfamily member 16 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z0W1-1." [PRO:DNx, UniProtKB:Q9Z0W1]


organism-sequence



PR:Q9Z0W1-2

tumor necrosis factor receptor superfamily member 16 isoform m2 (mouse)

mNGFR/iso:m2


"A tumor necrosis factor receptor superfamily member 16 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z0W1-2." [PRO:DNx, UniProtKB:Q9Z0W1]


modification



PR:000018467

tumor necrosis factor receptor superfamily member 16, signal peptide removed form

NGFR/SigPep-


"A tumor necrosis factor receptor superfamily member 16 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000048602

tumor necrosis factor receptor superfamily member 16, signal peptide removed form (human)

hNGFR/SigPep-


"A tumor necrosis factor receptor superfamily member 16 (human) that has had the signal peptide removed. UniProtKB:P08138, 29-427." [PRO:DNx, Reactome:R-HSA-193664]


gene



PR:000001958

tumor necrosis factor receptor superfamily member 1A

TNFRSF1A


"A death receptor that is a translation product of the human TNFRSF1A gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P19438

tumor necrosis factor receptor superfamily member 1A (human)

hTNFRSF1A


"A tumor necrosis factor receptor superfamily member 1A that is encoded in the genome of human." [PRO:WCB, UniProtKB:P19438]


organism-sequence



PR:P19438-1

tumor necrosis factor receptor superfamily member 1A isoform 1 (human)

hTNFRSF1A/iso:1


"A tumor necrosis factor receptor superfamily member 1A isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P19438-2

tumor necrosis factor receptor superfamily member 1A isoform h2 (human)

hTNFRSF1A/iso:h2


"A tumor necrosis factor receptor superfamily member 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19438-2." [PRO:DNx, UniProtKB:P19438]


organism-sequence



PR:P19438-3

tumor necrosis factor receptor superfamily member 1A isoform h3 (human)

hTNFRSF1A/iso:h3


"A tumor necrosis factor receptor superfamily member 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19438-3." [PRO:DNx, UniProtKB:P19438]


organism-sequence



PR:P19438-4

tumor necrosis factor receptor superfamily member 1A isoform h4 (human)

hTNFRSF1A/iso:h4


"A tumor necrosis factor receptor superfamily member 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19438-4." [PRO:DNx, UniProtKB:P19438]


organism-sequence



PR:P19438-5

tumor necrosis factor receptor superfamily member 1A isoform h5 (human)

hTNFRSF1A/iso:h5


"A tumor necrosis factor receptor superfamily member 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19438-5." [PRO:DNx, UniProtKB:P19438]


organism-modification



PR:000028386

tumor necrosis factor receptor superfamily member 1A, signal peptide removed form (human)

hTNFRSF1A/SigPep-


"A tumor necrosis factor receptor superfamily member 1A, signal peptide removed form in human. Example: UniProtKB:P19438-1, 30-455." [PRO:DNx]


Yes
organism-modification



PR:000045702

tumor necrosis factor receptor superfamily member 1A phosphorylated 1 (human)

hTNFRSF1A/Phos:1


"A tumor necrosis factor receptor superfamily member 1A (human) that has been phosphorylated on the residue at the position equivalent to Ser-381 of the amino acid sequence represented by UniProtKB:P19438-1. Example: UniProtKB:P19438-1, Ser-381, MOD:00046." [iPTMnet:P19438, PMID:21724995]


organism-gene



PR:P22934

tumor necrosis factor receptor superfamily member 1A (rat)

rTNFRSF1A


"A tumor necrosis factor receptor superfamily member 1A that is encoded in the genome of rat." [OMA:P22934, PRO:DNx]


organism-gene



PR:P25118

tumor necrosis factor receptor superfamily member 1A (mouse)

mTNFRSF1A


"A tumor necrosis factor receptor superfamily member 1A that is encoded in the genome of mouse." [OMA:P25118, PRO:DNx]


organism-sequence



PR:P25118-1

tumor necrosis factor receptor superfamily member 1A isoform 1 (mouse)

mTNFRSF1A/iso:1


"A tumor necrosis factor receptor superfamily member 1A isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002231

tumor necrosis factor receptor superfamily member 1A isoform 1

TNFRSF1A/iso:1


"A tumor necrosis factor receptor superfamily member 1A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19438-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P19438-1

tumor necrosis factor receptor superfamily member 1A isoform 1 (human)

hTNFRSF1A/iso:1


"A tumor necrosis factor receptor superfamily member 1A isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P25118-1

tumor necrosis factor receptor superfamily member 1A isoform 1 (mouse)

mTNFRSF1A/iso:1


"A tumor necrosis factor receptor superfamily member 1A isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


modification



PR:000018612

tumor necrosis factor receptor superfamily member 1A, signal peptide removed form

TNFRSF1A/SigPep-


"A tumor necrosis factor receptor superfamily member 1A that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000028386

tumor necrosis factor receptor superfamily member 1A, signal peptide removed form (human)

hTNFRSF1A/SigPep-


"A tumor necrosis factor receptor superfamily member 1A, signal peptide removed form in human. Example: UniProtKB:P19438-1, 30-455." [PRO:DNx]


Yes
modification



PR:000018613

tumor necrosis factor receptor superfamily member 1A proteolytic cleavage product

TNFRSF1A/ClvPrd


"A tumor necrosis factor receptor superfamily member 1A that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000016486

tumor necrosis factor receptor superfamily member 6B

TNFRSF6B


"A death receptor that is a translation product of the human TNFRSF6B gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O95407

tumor necrosis factor receptor superfamily member 6B (human)

hTNFRSF6B


"A tumor necrosis factor receptor superfamily member 6B that is encoded in the genome of human." [PRO:DNx, UniProtKB:O95407]


organism-modification



PR:000049497

tumor necrosis factor receptor superfamily member 6B, signal peptide removed form (human)

hTNFRSF6B/SigPep-


"A tumor necrosis factor receptor superfamily member 6B (human) that has had the signal peptide removed. UniProtKB:O95407, 30-300." [PRO:DNx, Reactome:R-HSA-5675950]


organism-modification



PR:000050900

tumor necrosis factor receptor superfamily member 6B O-glycosylated 1 (human)

hTNFRSF6B/OGlyco:1


"A tumor necrosis factor receptor superfamily member 6B (human) that has been O-glycosylated at the residue equivalent to Thr-203 of the amino acid sequence represented by UniProtKB:O95407-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O95407-1, Thr-203, MOD:00005~GNO:G43417UB." [GlyGen:O95407-1, PMID:30459171, PRO:DNx]


modification



PR:000021707

tumor necrosis factor receptor superfamily member 6B, signal peptide removed form

TNFRSF6B/SigPep-


"A tumor necrosis factor receptor superfamily member 6B that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000049497

tumor necrosis factor receptor superfamily member 6B, signal peptide removed form (human)

hTNFRSF6B/SigPep-


"A tumor necrosis factor receptor superfamily member 6B (human) that has had the signal peptide removed. UniProtKB:O95407, 30-300." [PRO:DNx, Reactome:R-HSA-5675950]


family



PR:000001951

tumor necrosis factor receptor superfamily member 10A/B

CD40LG


"A death receptor with core architecture consisting of a signal sequence, an extracellular region containing three TNFR/NGFR cysteine-rich region domains (Pfam:PF00020), a transmembrane region, and an intracellular region containing a Death domain (Pfam:PF00531). There are two genes in human, TNFRSF10A and TNFRSF10B, more closely related to each other than to mouse TNFRSF10B." [PRO:WCB]


gene



PR:000002108

tumor necrosis factor receptor superfamily member 10A

TNFRSF10A


"A tumor necrosis factor receptor superfamily member 10A/B that is a translation product of the human TNFRSF10A gene or a 1:1 ortholog thereof. No mouse gene has been assigned this name." [PRO:WCB]


organism-gene



PR:O00220

tumor necrosis factor receptor superfamily member 10A (human)

hTNFRSF10A


"A tumor necrosis factor receptor superfamily member 10A that is encoded in the genome of human." [PRO:WCB, UniProtKB:O00220]


organism-sequence



PR:O00220-1

tumor necrosis factor receptor superfamily member 10A isoform 1 (human)

hTNFRSF10A/iso:1


"A tumor necrosis factor receptor superfamily member 10A isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000049485

tumor necrosis factor receptor superfamily member 10A, signal peptide removed form (human)

hTNFRSF10A/SigPep-


"A tumor necrosis factor receptor superfamily member 10A (human) that has had the signal peptide removed. UniProtKB:O00220, 24-468." [PRO:DNx, Reactome:R-HSA-5633393]


organism-modification



PR:000050628

tumor necrosis factor receptor superfamily member 10A O-glycosylated 1 (human)

hTNFRSF10A/OGlyco:1


"A tumor necrosis factor receptor superfamily member 10A (human) that has been O-glycosylated at the residue equivalent to Ser-126 of the amino acid sequence represented by UniProtKB:O00220-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O00220-1, Ser-126, MOD:00002~GNO:G43417UB." [GlyGen:O00220-1, PMID:30459171, PRO:DNx]


sequence



PR:000002225

tumor necrosis factor receptor superfamily member 10A isoform 1

TNFRSF10A/iso:1


"A tumor necrosis factor receptor superfamily member 10A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00220-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:O00220-1

tumor necrosis factor receptor superfamily member 10A isoform 1 (human)

hTNFRSF10A/iso:1


"A tumor necrosis factor receptor superfamily member 10A isoform 1 that is encoded in the genome of human." [PRO:JAN]


gene



PR:000002109

tumor necrosis factor receptor superfamily member 10B

TNFRSF10B


"A tumor necrosis factor receptor superfamily member 10A/B that is a translation product of the human TNFRSF10B gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:O14763

tumor necrosis factor receptor superfamily member 10B (human)

hTNFRSF10B


"A tumor necrosis factor receptor superfamily member 10B that is encoded in the genome of human." [PRO:WCB, UniProtKB:O14763]


organism-sequence



PR:O14763-1

tumor necrosis factor receptor superfamily member 10B isoform Long (human)

hTNFRSF10B/iso:Long


"A tumor necrosis factor receptor superfamily member 10B isoform 2 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:O14763-2

tumor necrosis factor receptor superfamily member 10B isoform Short (human)

hTNFRSF10B/iso:Short


"A tumor necrosis factor receptor superfamily member 10B isoform 3 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:O14763-3

tumor necrosis factor receptor superfamily member 10B isoform h3 (human)

hTNFRSF10B/iso:h3


"A tumor necrosis factor receptor superfamily member 10B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14763-3." [PRO:DNx, UniProtKB:O14763]


organism-modification



PR:000049486

tumor necrosis factor receptor superfamily member 10B, signal peptide removed form (human)

hTNFRSF10B/SigPep-


"A tumor necrosis factor receptor superfamily member 10B (human) that has had the signal peptide removed. UniProtKB:O14763, 56-440." [PRO:DNx, Reactome:R-HSA-65505]


organism-modification



PR:000075579

tumor necrosis factor receptor superfamily member 10B deaminated 1 (human)

hTNFRSF10B/Deam:1


"A tumor necrosis factor receptor superfamily member 10B (human) that has been deaminated on the residue at the position equivalent to Asn-366 of the amino acid sequence represented by UniProtKB:O14763-1. Example: UniProtKB:O14763-1, Asn-366, MOD:00684." [IEDB_epitope:1351198, PRO:DNx]


sequence



PR:000002227

tumor necrosis factor receptor superfamily member 10B isoform 1

TNFRSF10B/iso:1


"A tumor necrosis factor receptor superfamily member 10B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QZM4-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:Q9QZM4-1

tumor necrosis factor receptor superfamily member 10B isoform 1 (mouse)

mTNFRSF10B/iso:1


"A tumor necrosis factor receptor superfamily member 10B isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002228

tumor necrosis factor receptor superfamily member 10B isoform 2

TNFRSF10B/iso:2


"A tumor necrosis factor receptor superfamily member 10B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14763-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:O14763-1

tumor necrosis factor receptor superfamily member 10B isoform Long (human)

hTNFRSF10B/iso:Long


"A tumor necrosis factor receptor superfamily member 10B isoform 2 that is encoded in the genome of human." [PRO:JAN]


modification



PR:000026570

tumor necrosis factor receptor superfamily member 10B isoform 2, signal peptide removed form

TNFRSF10B/iso:2/SigPep-


"A tumor necrosis factor receptor superfamily member 10B isoform 2 that has had the signal peptide removed." [PRO:DNx]


sequence



PR:000002229

tumor necrosis factor receptor superfamily member 10B isoform 3

TNFRSF10B/iso:3


"A tumor necrosis factor receptor superfamily member 10B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14763-2 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:O14763-2

tumor necrosis factor receptor superfamily member 10B isoform Short (human)

hTNFRSF10B/iso:Short


"A tumor necrosis factor receptor superfamily member 10B isoform 3 that is encoded in the genome of human." [PRO:JAN]


modification



PR:000018723

tumor necrosis factor receptor superfamily member 10B, signal peptide removed form

TNFRSF10B/SigPep-


"A tumor necrosis factor receptor superfamily member 10B that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026570

tumor necrosis factor receptor superfamily member 10B isoform 2, signal peptide removed form

TNFRSF10B/iso:2/SigPep-


"A tumor necrosis factor receptor superfamily member 10B isoform 2 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000049486

tumor necrosis factor receptor superfamily member 10B, signal peptide removed form (human)

hTNFRSF10B/SigPep-


"A tumor necrosis factor receptor superfamily member 10B (human) that has had the signal peptide removed. UniProtKB:O14763, 56-440." [PRO:DNx, Reactome:R-HSA-65505]


Back to top
MAP2K4/Phos:1 forms found in complexes   

MAP2K4/Phos:1 Component
Complexes
PR:000028386 hTNFRSF1A/SigPep- PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)