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Protein Ontology report - E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1

PR:000025627 - http://purl.obolibrary.org/obo/PR_000025627

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000025627

PRO name

E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1

Synonyms

PRO-Short-label:

EXACT:

SIAH1/iso:1/Phos:1

Definition

"An E3 ubiquitin-protein ligase SIAH1 isoform 1 that has been phosphorylated on Tyr residues by activation of the JNK pathway. Example: UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048." [PMID:16230351, PMID:9482736, PRO:DAN, PRO:JAN]

PRO Category

modification

Parent

PR:000025622 E3 ubiquitin-protein ligase SIAH1 isoform 1
PR:000037070 phosphoprotein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	1	Organism-Modification	1

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

modification

PR:000025627 E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1

SIAH1/iso:1/Phos:1

organism-modification

PR:000025641 E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human)

hSIAH1/iso:1/Phos:1

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000025641 hSIAH1/iso:1/Phos:1 UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048	acts_upstream_of_or_within	GO:0043525 positive regulation of neuron apoptotic process	PMID:16230351
	acts_upstream_of_or_within	GO:0070304 positive regulation of stress-activated protein kinase signaling cascade	PMID:16230351
	enables	increased GO:0005515 protein binding with PR:Q69ZI1-1	PMID:16230351