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Protein Ontology report - tyrosine-protein kinase SYK isoform 1
PR:000025832 - http://purl.obolibrary.org/obo/PR_000025832
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000025832   
  PRO nametyrosine-protein kinase SYK isoform 1 
  Synonyms
PRO-Short-label: EXACT:SYK/iso:1
  Definition"A tyrosine-protein kinase SYK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48025-1 or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000003065 tyrosine-protein kinase SYK
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification1                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000025832
tyrosine-protein kinase SYK isoform 1
SYK/iso:1
"A tyrosine-protein kinase SYK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48025-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:P43405-1
tyrosine-protein kinase SYK isoform Long (human)
hSYK/iso:Long
"A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:P48025-1
tyrosine-protein kinase SYK isoform 1 (mouse)
mSYK/iso:1
"A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000025834
tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)
mSYK/iso:1/Phos:1
"A tyrosine-protein kinase SYK isoform 1 phosphorylated 1 in mouse. UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:JAN]
Yes
organism-modification


PR:000049791
tyrosine-protein kinase SYK isoform 1 phosphorylated 2 (mouse)
mSYK/iso:1/Phos:2
"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342. UniProtKB:P48025-1, Tyr-342, MOD:00048." [PMID:27609517, PRO:LN]

organism-modification


PR:000049792
tyrosine-protein kinase SYK isoform 1 unphosphorylated 2 (mouse)
mSYK/iso:1/UnPhos:2
"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 342. UniProtKB:P48025-1, Tyr-342, PR:000026291." [PMID:27609517, PRO:LN]

organism-modification


PR:000049793
tyrosine-protein kinase SYK isoform 1 phosphorylated 3 (mouse)
mSYK/iso:1/Phos:3
"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-346. UniProtKB:P48025-1, Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]

organism-modification


PR:000049794
tyrosine-protein kinase SYK isoform 1 unphosphorylated 3 (mouse)
mSYK/iso:1/UnPhos:3
"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 346. UniProtKB:P48025-1, Tyr-346, PR:000026291." [PMID:27609517, PRO:LN]

organism-modification


PR:000049795
tyrosine-protein kinase SYK isoform 1 phosphorylated 4 (mouse)
mSYK/iso:1/Phos:4
"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342 and Tyr-346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]

organism-modification


PR:000049796
tyrosine-protein kinase SYK isoform 1 phosphorylated 5 (mouse)
mSYK/iso:1/Phos:5
"A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342, Tyr-346, Tyr-519 and Tyr-520. UniProtKB:P48025-1, Tyr-342/Tyr-346/Tyr-519/Tyr-520, MOD:00048." [PMID:27609517, PRO:LN]

organism-modification


PR:000049800
tyrosine-protein kinase SYK isoform 1 phosphorylated 6 (mouse)
mSYK/iso:1/Phos:6
"A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at positions 519 and 520, but it is still phosphorylated at Tyr 342 and 346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048|Tyr-519/Tyr-520, PR:000026291." [PMID:27609517, PRO:LN]

modification


PR:000025833
tyrosine-protein kinase SYK isoform 1 phosphorylated 1
SYK/iso:1/Phos:1
"A tyrosine-protein kinase SYK isoform 1 that has been phosphorylated on several Tyr residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lyn. Example: UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:CNA, PRO:DAN]

organism-modification


PR:000025834
tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)
mSYK/iso:1/Phos:1
"A tyrosine-protein kinase SYK isoform 1 phosphorylated 1 in mouse. UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:JAN]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025834 mSYK/iso:1/Phos:1
UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048		 acts_upstream_of_or_withinGO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis PMID:15536084
enablesGO:0019901 protein kinase binding with PR:P09769 FGR PMID:15536084
GO:0031625 ubiquitin protein ligase binding PMID:15536084
GO:0043548 phosphatidylinositol 3-kinase binding PMID:15536084