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Protein Ontology report - siroheme synthase
PR:000025879 - http://purl.obolibrary.org/obo/PR_000025879
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000025879   
  PRO namesiroheme synthase 
  Definition"A protein that is a multifunctional enzyme of the siroheme and cobalamin (vitamin B12) biosynthesis pathways, represents a fusion between uroporphyrin-III C-methyltransferase (SUMT) and precorrin-2 oxidase/chelatase. It contains a Sirohaem synthase dimerisation region (Pfam:PF10414) followed by the Tetrapyrrole (Corrin/Porphyrin) Methylases (Pfam:PF00590) domain." [PIRSF:PIRSF036426] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF036426
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000025879 siroheme synthase
chick-SERPINB14/iso:1/InitMet-/AcNGlycoPhos:1

gene


PR:000022378 siroheme synthase cysG
cysG

organism-gene


PR:O74468 probable uroporphyrinogen-III C-methyltransferase (Schizosaccharomyces pombe 972h-)
Spom972h-cysG

organism-gene


PR:P0AEA8 siroheme synthase (Escherichia coli K-12)
Ec-cysG

organism-gene


PR:P25924 siroheme synthase (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2)
cysG (SALTY)

modification


PR:000025881 siroheme synthase cysG phosphorylated 1
cysG/Phos:1

organism-modification


PR:000025882 siroheme synthase cysG phosphorylated 1 (Salmonella typhimurium)
cysG/Phos:1 (SALTM)
Yes
modification


PR:000025883 siroheme synthase cysG unmodified form
cysG/UnMod

organism-modification


PR:000025884 siroheme synthase cysG unmodified form (Salmonella typhimurium)
cysG/UnMod (SALTM)
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025882 cysG/Phos:1 (SALTM)
UniProtKB:P25924, Ser-128, MOD:00046		 enablesdecreased GO:0043115 precorrin-2 dehydrogenase activity relative to PR:000025884 cysG/UnMod (SALTM) PDB:1PJQ; PMID:14595395
PR:000025884 cysG/UnMod (SALTM) enablesGO:0043115 precorrin-2 dehydrogenase activity PDB:1PJQ; PMID:14595395