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Protein Ontology report - siroheme synthase
PR:000025879 - http://purl.obolibrary.org/obo/PR_000025879
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000025879   
  PRO namesiroheme synthase 
  Definition"A protein that is a multifunctional enzyme of the siroheme and cobalamin (vitamin B12) biosynthesis pathways, represents a fusion between uroporphyrin-III C-methyltransferase (SUMT) and precorrin-2 oxidase/chelatase. It contains a Sirohaem synthase dimerisation region (Pfam:PF10414) followed by the Tetrapyrrole (Corrin/Porphyrin) Methylases (Pfam:PF00590) domain." [PIRSF:PIRSF036426
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF036426
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000025879

siroheme synthase

chick-SERPINB14/iso:1/InitMet-/AcNGlycoPhos:1


"A protein that is a multifunctional enzyme of the siroheme and cobalamin (vitamin B12) biosynthesis pathways, represents a fusion between uroporphyrin-III C-methyltransferase (SUMT) and precorrin-2 oxidase/chelatase. It contains a Sirohaem synthase dimerisation region (Pfam:PF10414) followed by the Tetrapyrrole (Corrin/Porphyrin) Methylases (Pfam:PF00590) domain." [PIRSF:PIRSF036426]


gene



PR:000022378

siroheme synthase cysG

cysG


"A siroheme synthase that is a translation product of the Escherichia coli K-12 cysG gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O74468

probable uroporphyrinogen-III C-methyltransferase (Schizosaccharomyces pombe 972h-)

Spom972h-cysG


"A siroheme synthase cysG that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O74468, PRO:DNx]


organism-gene



PR:P0AEA8

siroheme synthase (Escherichia coli K-12)

Ec-cysG


"A siroheme synthase cysG that is encoded in the genome of Escherichia coli K-12." [PRO:CNA, UniProtKB:P0AEA8]


organism-gene



PR:P25924

siroheme synthase (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2)

cysG (SALTY)


"A siroheme synthase cysG that is encoded in the genome of Salmonella enterica subsp. enterica serovar Typhimurium str. LT2." [PRO:CNA]


modification



PR:000025881

siroheme synthase cysG phosphorylated 1

cysG/Phos:1


"A siroheme synthase cysG that has been post-translationally modified to include a phosphorylated serine that projects into the ferrochelatase-dehydrogenase active site cavity. Example: UniProtKB:P25924, Ser-128, MOD:00046." [PRO:CNA, PRO:DAN]


organism-modification



PR:000025882

siroheme synthase cysG phosphorylated 1 (Salmonella typhimurium)

cysG/Phos:1 (SALTM)


"A siroheme synthase cysG phosphorylated 1 in Salmonella typhimurium. UniProtKB:P25924, Ser-128, MOD:00046." [OCA:JP, PMID:14595395]

Yes

modification



PR:000025883

siroheme synthase cysG unmodified form

cysG/UnMod


"A siroheme synthase cysG that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]


organism-modification



PR:000025884

siroheme synthase cysG unmodified form (Salmonella typhimurium)

cysG/UnMod (SALTM)


"A siroheme synthase cysG unmodified form in Salmonella typhimurium." [PRO:CNA, PRO:DAN]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025882 cysG/Phos:1 (SALTM)
UniProtKB:P25924, Ser-128, MOD:00046
enablesdecreased GO:0043115 precorrin-2 dehydrogenase activity relative to PR:000025884 cysG/UnMod (SALTM) PDB:1PJQ; PMID:14595395
PR:000025884 cysG/UnMod (SALTM) enablesGO:0043115 precorrin-2 dehydrogenase activity PDB:1PJQ; PMID:14595395