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Protein Ontology report - TGF-beta receptor type-1, signal peptide removed form
PR:000025932 -
http://purl.obolibrary.org/obo/PR_000025932
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000025932
PRO name
TGF-beta receptor type-1, signal peptide removed form
Synonyms
PRO-Short-label
:
EXACT:
TGFBR1/SigPep-
Definition
"A TGF-beta receptor type-1 that has had the signal peptide removed." [PRO:CNA]
PRO Category
modification
Parent
PR:000000047
TGF-beta receptor type-1
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
5
Organism-Modification
12
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000025932
TGF-beta receptor type-1, signal peptide removed form
TGFBR1/SigPep-
"A TGF-beta receptor type-1 that has had the signal peptide removed." [PRO:CNA]
modification
PR:000000522
TGF-beta receptor type-1 isoform 1, signal peptide removed form
TGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1 that has had the signal peptide removed." [PRO:CNA]
modification
PR:000000408
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form
TGFBR1/iso:1/SigPep-/PhosRes+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that includes at least one phosphorylated residue." [PRO:CNA]
modification
PR:000000523
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1
TGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif region (GSGSGLP and surrounding sequence) by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification
PR:000036434
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]
Yes
modification
PR:000003173
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form
TGFBR1/iso:1/SigPep-/PhosUbiq+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]
modification
PR:000003173
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form
TGFBR1/iso:1/SigPep-/PhosUbiq+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification
PR:000049432
TGF-beta receptor type-1, signal peptide removed form (human)
hTGFBR1/SigPep-
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification
PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]
organism-modification
PR:000060809
TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)
hTGFBR1/var:G52R/SigPep-
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Gly-52 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Gly-52, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3656368]
organism-modification
PR:000060890
TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:R414*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Arg-413 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-413, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656508]
organism-modification
PR:000061254
TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)
hTGFBR1/var:P83L/SigPep-
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3656341]
organism-modification
PR:000061891
TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)
hTGFBR1/var:P83S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656326]
organism-modification
PR:000063489
TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)
hTGFBR1/var:C41Y/SigPep-
"A TGF-beta receptor type-1 (human) that has a Tyr residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Cys-41, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3656328]
organism-modification
PR:000063569
TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)
hTGFBR1/var:N45S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Asn-45 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Asn-45, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656348]
organism-modification
PR:000064307
TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:W242*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-241, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656504]
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TGFBR1/SigPep-
forms found in complexes
TGFBR1/SigPep-
Component
Complexes
PR:000000523
TGFBR1/iso:1/SigPep-/Phos:1
PR:000025975
transforming growth factor beta type I receptor homodimeric complex phosphorylated form
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
PR:000025961
transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
acts_upstream_of_or_within
GO:0006468
protein phosphorylation
PMID:7774578
GO:0007165
signal transduction
PMID:8242743
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:8947046
enables
GO:0005025
transforming growth factor beta receptor activity, type I
PMID:7774578
;
PMID:8947046
located_in
GO:0005886
plasma membrane
PMID:8947046
PR:000036432
hTGFBR1/iso:1/SigPep-
UniProtKB:P36897-1, 34-503
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:8242743
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:8242743
located_in
GO:0005886
plasma membrane
PMID:8242743
PR:000036434
mTGFBR1/iso:1/SigPep-/Phos:1
UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
acts_upstream_of_or_within
GO:0006468
protein phosphorylation
PMID:12065756
