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Protein Ontology report - beclin-1 isoform 1
PR:000027468 - http://purl.obolibrary.org/obo/PR_000027468
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000027468   
  PRO namebeclin-1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:BECN1/iso:1
  Definition"A beclin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14457-1 or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000004719 beclin-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000027468 beclin-1 isoform 1
BECN1/iso:1

organism-sequence


PR:O88597-1 beclin-1 isoform 1 (mouse)
mBECN1/iso:1

organism-sequence


PR:Q14457-1 beclin-1 isoform 1 (human)
hBECN1/iso:1

organism-modification


PR:000027471 beclin-1 isoform 1 phosphorylated 1 (human)
hBECN1/iso:1/Phos:1
Yes
organism-modification


PR:000027487 beclin-1 isoform 1 unmodified form (human)
hBECN1/iso:1/UnMod

modification


PR:000027470 beclin-1 isoform 1 phosphorylated 1
BECN1/iso:1/Phos:1

organism-modification


PR:000027471 beclin-1 isoform 1 phosphorylated 1 (human)
hBECN1/iso:1/Phos:1
Yes
modification


PR:000027486 beclin-1 isoform 1 unmodified form
BECN1/iso:1/UnMod

organism-modification


PR:000027487 beclin-1 isoform 1 unmodified form (human)
hBECN1/iso:1/UnMod

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027471 hBECN1/iso:1/Phos:1
UniProtKB:Q14457-1, Thr-119, MOD:00047		 acts_upstream_of_or_withinGO:0010508 positive regulation of autophagy PMID:19180116; PMID:19395874
enablesdecreased GO:0005515 protein binding with PR:P10415 BCL2 PMID:19180116
decreased GO:0005515 protein binding with PR:Q07817-1 PMID:19180116